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Protein

BRCA1-associated protein homolog 2

Gene

brap-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Controls the stress response to increased levels of reactive oxygen species by modulating the brc-1-dependent expression of cki-1.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri260 – 297RING-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri308 – 369UBP-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

Keywordsi

Biological processStress response
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CEL-5675221 Negative regulation of MAPK pathway

Names & Taxonomyi

Protein namesi
Recommended name:
BRCA1-associated protein homolog 2Imported
Gene namesi
Name:brap-2Imported
ORF Names:EEED8.16Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiEEED8.16 ; CE28903 ; WBGene00017144 ; brap-2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000563241 – 590BRCA1-associated protein homolog 2CuratedAdd BLAST590

Proteomic databases

EPDiQ95QN6
PaxDbiQ95QN6
PeptideAtlasiQ95QN6

PTM databases

iPTMnetiQ95QN6

Expressioni

Gene expression databases

BgeeiWBGene00017144

Interactioni

Protein-protein interaction databases

BioGridi39261, 1 interactor
DIPiDIP-24711N
IntActiQ95QN6, 1 interactor
STRINGi6239.EEED8.16.1

Structurei

3D structure databases

ProteinModelPortaliQ95QN6
SMRiQ95QN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi100 – 103Poly-Ser4
Compositional biasi576 – 581Poly-Ser6
Compositional biasi587 – 590Poly-Lys4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri260 – 297RING-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri308 – 369UBP-typePROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0804 Eukaryota
ENOG410XSS2 LUCA
GeneTreeiENSGT00500000044909
HOGENOMiHOG000190616
InParanoidiQ95QN6
KOiK10632
OMAiNQYMALI
OrthoDBiEOG091G07BQ
PhylomeDBiQ95QN6

Family and domain databases

CDDicd12718 RRM_BRAP2, 1 hit
Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR011422 BRAP2
IPR034932 BRAP2_RRM
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP
PfamiView protein in Pfam
PF07576 BRAP2, 1 hit
PF13639 zf-RING_2, 1 hit
PF02148 zf-UBP, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD017029 BRAP2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00290 ZnF_UBP, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit
PS50271 ZF_UBP, 1 hit

Sequencei

Sequence statusi: Complete.

Q95QN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLYVPLVL RLEVRDRTKI VQSFIDDSKA GSESPLAGER TRQRLVKKGN
60 70 80 90 100
TPPKKELKGR EEDPPIGVMS SEPSHNYHKG RRTYSEVVIE SLDGEKLVDS
110 120 130 140 150
SSSVAGTSEK SGGRSVSEGP PDQVAYYSGN PLTEKTEGIM HFYKYNDEKL
160 170 180 190 200
TKVAQCRMLC MYAVPAQVEV REIISFMCIS LPMIVSIKVV RDPAPNQYML
210 220 230 240 250
IIKFKEHNDA VTFYEEFNNC PFNDLESYCC TLFFVDRIEC TTSNDLFSSD
260 270 280 290 300
DTSLTELPTC AVCLERMDDS VLAILCNHSF HARCLEQWAD NTCPVCRYVQ
310 320 330 340 350
SPEVVAEQRC NDCGMSNDLW ICLICGNIGC GRYAEQHAQR HWELTSHTYS
360 370 380 390 400
LKVGGERVWD YAGDNYVHRL IENGADGKLV EYQRESNASF DDKNQKGGDK
410 420 430 440 450
LEGIKLEYTL LLTSQLEDQR KYFEGLRHDM EQTMSKMEKT AYAQVENLEH
460 470 480 490 500
QLTERSTELK SLKGDLDDTV TARKVAEKRA TQTNEKVNKL ANELKDEREI
510 520 530 540 550
NQMLRKDQQV WKGQVEKLIE SQKTARTEYE KKIEDLQSQV NDLLMHFETQ
560 570 580 590
NKLKEQLDAG KITQEEITES QVELDSSSSS SRKLNRKKKK
Length:590
Mass (Da):67,414
Last modified:December 1, 2001 - v1
Checksum:i56EA3FEEBD7D9CE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081042 Genomic DNA Translation: CCD68743.1
RefSeqiNP_495016.1, NM_062615.5
UniGeneiCel.17546

Genome annotation databases

EnsemblMetazoaiEEED8.16; EEED8.16; WBGene00017144
GeneIDi173917
KEGGicel:CELE_EEED8.16
UCSCiEEED8.16 c. elegans

Similar proteinsi

Entry informationi

Entry nameiBRAP2_CAEEL
AccessioniPrimary (citable) accession number: Q95QN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase

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