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Protein

Dwarfin sma

Gene

daf-3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-CEL-201451 Signaling by BMP
R-CEL-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
SignaLinkiQ95QI8

Names & Taxonomyi

Protein namesi
Recommended name:
Dwarfin smaUniRule annotation
Gene namesi
Name:daf-3Imported
ORF Names:CELE_F25E2.5Imported, F25E2.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF25E2.5b ; CE30963 ; WBGene00000899 ; daf-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiWBGene00000899 Expressed in 5 organ(s), highest expression level in material anatomical entity

Structurei

3D structure databases

ProteinModelPortaliQ95QI8
SMRiQ95QI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 319MH1InterPro annotationAdd BLAST156
Domaini629 – 852MH2InterPro annotationAdd BLAST224

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili208 – 235Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3701 Eukaryota
ENOG410XQKU LUCA
GeneTreeiENSGT00760000119091
HOGENOMiHOG000018470

Family and domain databases

Gene3Di2.60.200.10, 1 hit
3.90.520.10, 1 hit
InterProiView protein in InterPro
IPR013790 Dwarfin
IPR003619 MAD_homology1_Dwarfin-type
IPR013019 MAD_homology_MH1
IPR017855 SMAD-like_dom_sf
IPR001132 SMAD_dom_Dwarfin-type
IPR008984 SMAD_FHA_dom_sf
IPR036578 SMAD_MH1_sf
PANTHERiPTHR13703 PTHR13703, 3 hits
PfamiView protein in Pfam
PF03165 MH1, 1 hit
PF03166 MH2, 1 hit
SMARTiView protein in SMART
SM00523 DWA, 1 hit
SM00524 DWB, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF56366 SSF56366, 1 hit
PROSITEiView protein in PROSITE
PS51075 MH1, 1 hit
PS51076 MH2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q95QI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDHHNLTGL PGTSIPPQFN YSQPGTSTGG PLYGGKPSHG LEDIPDVEEY
60 70 80 90 100
ERNLLGAGAG FNLLNVGNMA NVPDEHTPMM SPVNTTTKIL QRSGIKMEIP
110 120 130 140 150
PYLDPDSQDD DPEDGVNYPD PDLFDTKNTN MTEYDLDVLK LGKPAVDEAR
160 170 180 190 200
KKIEVPDASA PPNKIVEYLM YYRTLKESEL IQLNAYRTKR NRLSLNLVKN
210 220 230 240 250
NIDREFDQKA CESLVKKLKD KKNDLQNLID VVLSKGTKYT GCITIPRTLD
260 270 280 290 300
GRLQVHGRKG FPHVVYGKLW RFNEMTKNET RHVDHCKHAF EMKSDMVGEA
310 320 330 340 350
LQVCVNPYHY EIVIGTMIVG QRDHDNRDMP PPHQRYHTPG RQDPVDDMSR
360 370 380 390 400
FIPPASIRPP PMNMHTRPQP MPQQLPSVGA TFAHPLPHQA PHNPGVSHPY
410 420 430 440 450
SIAPQTHYPL NMNPIPQMPQ MPQMPPPLHQ GYGMNGPSCS SENNNPFHQN
460 470 480 490 500
HHYNDISHPN HYSYDCGPNL YGFPTPYPDF HHPFNQQPHQ PPQLSQNHTS
510 520 530 540 550
QQGSHQPGHQ GQVPNDPPIS RPVLQPSTVT LDVFRRYCRQ TFGNRFFEGE
560 570 580 590 600
SEQSGAIIRS SNKFIEEFDS PICGVTVVRP RMTDGEVLEN IMPEDAPYHD
610 620 630 640 650
ICKFILRLTS ESVTFSGEGP EVSDLNEKWG TIVYYEKNLQ IGEKKCSRGN
660 670 680 690 700
FHVDGGFICS ENRYSLGLEP NPIREPVAFK VRKAIVDGIR FSYKKDGSVW
710 720 730 740 750
LQNRMKYPVF VTSGYLDEQS GGLKKDKVHK VYGCASIKTF GFNVSKQIIR
760 770 780 790 800
DALLSKQMAT MYLQGKLTPM NYIYEKKTQE ELRREATRTT DSLAKYCCVR
810 820 830 840 850
VSFCKGFGEA YPERPSIHDC PVWIELKINI AYDFMDSICQ YITNCFEPLG
860
MEDFAKLGIN VSDD
Length:864
Mass (Da):97,921
Last modified:October 1, 2002 - v2
Checksum:iFB66ACBF2164D34F
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q95QI7Q95QI7_CAEEL
Dwarfin sma
daf-3 CELE_F25E2.5, F25E2.5
892Annotation score:
O17532O17532_CAEEL
Dwarfin sma
daf-3 CELE_F25E2.5, F25E2.5
796Annotation score:
A0A0K3AWB3A0A0K3AWB3_CAEEL
Dwarfin sma
daf-3 CELE_F25E2.5, F25E2.5
858Annotation score:
A0A0K3AVK9A0A0K3AVK9_CAEEL
Dwarfin sma
daf-3 CELE_F25E2.5, F25E2.5
895Annotation score:
A0A0K3AYJ4A0A0K3AYJ4_CAEEL
Dwarfin sma
daf-3 CELE_F25E2.5, F25E2.5
783Annotation score:
A0A0K3ATA0A0A0K3ATA0_CAEEL
Dwarfin sma
daf-3 CELE_F25E2.5, F25E2.5
780Annotation score:
A0A0K3ASQ1A0A0K3ASQ1_CAEEL
Dwarfin sma
daf-3 CELE_F25E2.5, F25E2.5
861Annotation score:
A0A0K3AVL3A0A0K3AVL3_CAEEL
Dwarfin sma
daf-3 CELE_F25E2.5, F25E2.5
283Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCD69987.1
RefSeqiNP_001024604.1, NM_001029433.3
UniGeneiCel.1120

Genome annotation databases

EnsemblMetazoaiF25E2.5b; F25E2.5b; WBGene00000899
GeneIDi180431
UCSCiF25E2.5c c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCD69987.1
RefSeqiNP_001024604.1, NM_001029433.3
UniGeneiCel.1120

3D structure databases

ProteinModelPortaliQ95QI8
SMRiQ95QI8
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF25E2.5b; F25E2.5b; WBGene00000899
GeneIDi180431
UCSCiF25E2.5c c. elegans

Organism-specific databases

CTDi180431
WormBaseiF25E2.5b ; CE30963 ; WBGene00000899 ; daf-3

Phylogenomic databases

eggNOGiKOG3701 Eukaryota
ENOG410XQKU LUCA
GeneTreeiENSGT00760000119091
HOGENOMiHOG000018470

Enzyme and pathway databases

ReactomeiR-CEL-201451 Signaling by BMP
R-CEL-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
SignaLinkiQ95QI8

Gene expression databases

BgeeiWBGene00000899 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di2.60.200.10, 1 hit
3.90.520.10, 1 hit
InterProiView protein in InterPro
IPR013790 Dwarfin
IPR003619 MAD_homology1_Dwarfin-type
IPR013019 MAD_homology_MH1
IPR017855 SMAD-like_dom_sf
IPR001132 SMAD_dom_Dwarfin-type
IPR008984 SMAD_FHA_dom_sf
IPR036578 SMAD_MH1_sf
PANTHERiPTHR13703 PTHR13703, 3 hits
PfamiView protein in Pfam
PF03165 MH1, 1 hit
PF03166 MH2, 1 hit
SMARTiView protein in SMART
SM00523 DWA, 1 hit
SM00524 DWB, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF56366 SSF56366, 1 hit
PROSITEiView protein in PROSITE
PS51075 MH1, 1 hit
PS51076 MH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ95QI8_CAEEL
AccessioniPrimary (citable) accession number: Q95QI8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: October 1, 2002
Last modified: October 10, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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