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Entry version 161 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Smad protein daf-3

Gene

daf-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator and common SMAD (co-SMAD), required to regulate entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions (PubMed:9334330).

Probable component of transcriptional regulatory complex with SMAD protein daf-5 (PubMed:14681186).

Acts antagonistically to SMAD signaling downstream of TGF-beta-like daf-7 signaling (PubMed:20081192).

Binds to the 5'-GTCTG-3' motif found in regulatory regions and may modulate the expression of genes involved in TGF-beta-like daf-7 and Notch lag-2 signaling (PubMed:20081192, PubMed:9834189, PubMed:28811311).

May regulate gene expression outside the dauer pathway (PubMed:9834189).

5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Smad protein daf-32 Publications
Alternative name(s):
Abnormal dauer formation protein 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:daf-3Imported
ORF Names:F25E2.5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
F25E2.5a ; CE28002 ; WBGene00000899 ; daf-3
F25E2.5b ; CE30963 ; WBGene00000899 ; daf-3
F25E2.5c ; CE26364 ; WBGene00000899 ; daf-3
F25E2.5d ; CE50706 ; WBGene00000899 ; daf-3
F25E2.5e ; CE50732 ; WBGene00000899 ; daf-3
F25E2.5f ; CE28003 ; WBGene00000899 ; daf-3
F25E2.5g ; CE50852 ; WBGene00000899 ; daf-3
F25E2.5h ; CE50691 ; WBGene00000899 ; daf-3
F25E2.5i ; CE50737 ; WBGene00000899 ; daf-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi296P → L in mg125; suppresses the constitutive dauer arrest phenotype on a daf-7 mutant background. 1 Publication1
Mutagenesisi716G → E in mg132; suppresses the constitutive dauer arrest phenotype on a daf-7 mutant background. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004524031 – 892Smad protein daf-3Add BLAST892

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q95QI7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q95QI7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
WBGene00000899, Expressed in material anatomical entity and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q95QI7, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with R-SMADs daf-8 and daf-14 (PubMed:20081192).

Interacts with daf-14 in a daf-8 dependent manner (PubMed:20081192). May interact with daf-5 (PubMed:14681186).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-26559N

Protein interaction database and analysis system

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IntActi
Q95QI7, 15 interactors

STRING: functional protein association networks

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STRINGi
6239.F25E2.5a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q95QI7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini198 – 347MH1PROSITE-ProRule annotationAdd BLAST150
Domaini657 – 880MH2PROSITE-ProRule annotationAdd BLAST224

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 43DisorderedSequence analysisAdd BLAST43
Regioni135 – 161DisorderedSequence analysisAdd BLAST27
Regioni505 – 552DisorderedSequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 29Polar residuesSequence analysisAdd BLAST19
Compositional biasi138 – 152Acidic residuesSequence analysisAdd BLAST15
Compositional biasi514 – 541Polar residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dwarfin/SMAD family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3701, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_323960_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q95QI7

Identification of Orthologs from Complete Genome Data

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OMAi
CKHAFEM

Database of Orthologous Groups

More...
OrthoDBi
949229at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q95QI7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.200.10, 1 hit
3.90.520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013790, Dwarfin
IPR003619, MAD_homology1_Dwarfin-type
IPR013019, MAD_homology_MH1
IPR017855, SMAD-like_dom_sf
IPR001132, SMAD_dom_Dwarfin-type
IPR008984, SMAD_FHA_dom_sf
IPR036578, SMAD_MH1_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13703, PTHR13703, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF03165, MH1, 1 hit
PF03166, MH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00523, DWA, 1 hit
SM00524, DWB, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49879, SSF49879, 1 hit
SSF56366, SSF56366, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51075, MH1, 1 hit
PS51076, MH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: Q95QI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDHHNLTGL PGTSIPPQFN YSQPGTSTGG PLYGGKPSHG LEDIPDVEEY
60 70 80 90 100
ERNLLGAGAG FNLLNVGNMA NEFKPIITLD TKPPRDANKS LAFNGGLKLI
110 120 130 140 150
TPKTEVPDEH TPMMSPVNTT TKILQRSGIK MEIPPYLDPD SQDDDPEDGV
160 170 180 190 200
NYPDPDLFDT KNTNMTEYDL DVLKLGKPAV DEARKKIEVP DASAPPNKIV
210 220 230 240 250
EYLMYYRTLK ESELIQLNAY RTKRNRLSLN LVKNNIDREF DQKACESLVK
260 270 280 290 300
KLKDKKNDLQ NLIDVVLSKG TKYTGCITIP RTLDGRLQVH GRKGFPHVVY
310 320 330 340 350
GKLWRFNEMT KNETRHVDHC KHAFEMKSDM VCVNPYHYEI VIGTMIVGQR
360 370 380 390 400
DHDNRDMPPP HQRYHTPGRQ DPVDDMSRFI PPASIRPPPM NMHTRPQPMP
410 420 430 440 450
QQLPSVGATF AHPLPHQAPH NPGVSHPYSI APQTHYPLNM NPIPQMPQMP
460 470 480 490 500
QMPPPLHQGY GMNGPSCSSE NNNPFHQNHH YNDISHPNHY SYDCGPNLYG
510 520 530 540 550
FPTPYPDFHH PFNQQPHQPP QLSQNHTSQQ GSHQPGHQGQ VPNDPPISRP
560 570 580 590 600
VLQPSTVTLD VFRRYCRQTF GNRFFEGESE QSGAIIRSSN KFIEEFDSPI
610 620 630 640 650
CGVTVVRPRM TDGEVLENIM PEDAPYHDIC KFILRLTSES VTFSGEGPEV
660 670 680 690 700
SDLNEKWGTI VYYEKNLQIG EKKCSRGNFH VDGGFICSEN RYSLGLEPNP
710 720 730 740 750
IREPVAFKVR KAIVDGIRFS YKKDGSVWLQ NRMKYPVFVT SGYLDEQSGG
760 770 780 790 800
LKKDKVHKVY GCASIKTFGF NVSKQIIRDA LLSKQMATMY LQGKLTPMNY
810 820 830 840 850
IYEKKTQEEL RREATRTTDS LAKYCCVRVS FCKGFGEAYP ERPSIHDCPV
860 870 880 890
WIELKINIAY DFMDSICQYI TNCFEPLGME DFAKLGINVS DD
Length:892
Mass (Da):101,059
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i088B4E7B6359961F
GO
Isoform dImported (identifier: Q95QI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-330: M → MVGE

Show »
Length:895
Mass (Da):101,345
Checksum:i92B230921CFD7937
GO
Isoform fImported (identifier: Q95QI7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-105: Missing.

Show »
Length:858
Mass (Da):97,323
Checksum:i29125CBAA3C88FE6
GO
Isoform eImported (identifier: Q95QI7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-105: Missing.
     330-330: M → MVGE

Show »
Length:861
Mass (Da):97,608
Checksum:i5015958385EFB8F7
GO
Isoform bImported (identifier: Q95QI7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-105: Missing.
     330-330: M → MVGEALQ

Show »
Length:864
Mass (Da):97,921
Checksum:iFB66ACBF2164D34F
GO
Isoform cImported (identifier: Q95QI7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: MGDHHNLTGL...GLKLITPKTE → MKLIATSLL

Show »
Length:796
Mass (Da):90,918
Checksum:i61BA2122BAE25283
GO
Isoform gImported (identifier: Q95QI7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     330-330: M → MVGE

Show »
Length:783
Mass (Da):89,456
Checksum:i2253C71DD7636512
GO
Isoform hImported (identifier: Q95QI7-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Show »
Length:780
Mass (Da):89,171
Checksum:i1740D067469E21B0
GO
Isoform iImported (identifier: Q95QI7-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-609: Missing.

Show »
Length:283
Mass (Da):32,324
Checksum:i11137B4D6614E08C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0609931 – 609Missing in isoform i. CuratedAdd BLAST609
Alternative sequenceiVSP_0609941 – 112Missing in isoform g and isoform h. CuratedAdd BLAST112
Alternative sequenceiVSP_0609951 – 105MGDHH…TPKTE → MKLIATSLL in isoform c. Add BLAST105
Alternative sequenceiVSP_06099672 – 105Missing in isoform f, isoform e and isoform b. CuratedAdd BLAST34
Alternative sequenceiVSP_060997330M → MVGEALQ in isoform b. Curated1
Alternative sequenceiVSP_060998330M → MVGE in isoform d, isoform e and isoform g. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF005205 mRNA Translation: AAB61748.1
BX284606 Genomic DNA Translation: CCD69986.1
BX284606 Genomic DNA Translation: CCD69987.1
BX284606 Genomic DNA Translation: CCD69988.1
BX284606 Genomic DNA Translation: CTQ87052.1
BX284606 Genomic DNA Translation: CTQ87053.1
BX284606 Genomic DNA Translation: CTQ87054.1
BX284606 Genomic DNA Translation: CTQ87055.1
BX284606 Genomic DNA Translation: CTQ87056.1
BX284606 Genomic DNA Translation: CTQ87057.1

NCBI Reference Sequences

More...
RefSeqi
NP_001024604.1, NM_001029433.3 [Q95QI7-5]
NP_001024605.1, NM_001029434.2 [Q95QI7-6]
NP_001300341.1, NM_001313412.1 [Q95QI7-2]
NP_001300342.1, NM_001313413.1 [Q95QI7-4]
NP_001300343.1, NM_001313414.1 [Q95QI7-3]
NP_001300344.1, NM_001313415.1 [Q95QI7-7]
NP_001300345.1, NM_001313416.1
NP_001300346.1, NM_001313417.1 [Q95QI7-9]
NP_508161.3, NM_075760.4 [Q95QI7-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F25E2.5a.1; F25E2.5a.1; WBGene00000899 [Q95QI7-1]
F25E2.5b.1; F25E2.5b.1; WBGene00000899 [Q95QI7-5]
F25E2.5c.1; F25E2.5c.1; WBGene00000899 [Q95QI7-6]
F25E2.5d.1; F25E2.5d.1; WBGene00000899 [Q95QI7-2]
F25E2.5e.1; F25E2.5e.1; WBGene00000899 [Q95QI7-4]
F25E2.5f.1; F25E2.5f.1; WBGene00000899 [Q95QI7-3]
F25E2.5g.1; F25E2.5g.1; WBGene00000899 [Q95QI7-7]
F25E2.5g.2; F25E2.5g.2; WBGene00000899 [Q95QI7-7]
F25E2.5h.1; F25E2.5h.1; WBGene00000899 [Q95QI7-8]
F25E2.5h.2; F25E2.5h.2; WBGene00000899 [Q95QI7-8]
F25E2.5i.1; F25E2.5i.1; WBGene00000899 [Q95QI7-9]

Database of genes from NCBI RefSeq genomes

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GeneIDi
180431

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_F25E2.5

UCSC genome browser

More...
UCSCi
F25E2.5c, c. elegans [Q95QI7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005205 mRNA Translation: AAB61748.1
BX284606 Genomic DNA Translation: CCD69986.1
BX284606 Genomic DNA Translation: CCD69987.1
BX284606 Genomic DNA Translation: CCD69988.1
BX284606 Genomic DNA Translation: CTQ87052.1
BX284606 Genomic DNA Translation: CTQ87053.1
BX284606 Genomic DNA Translation: CTQ87054.1
BX284606 Genomic DNA Translation: CTQ87055.1
BX284606 Genomic DNA Translation: CTQ87056.1
BX284606 Genomic DNA Translation: CTQ87057.1
RefSeqiNP_001024604.1, NM_001029433.3 [Q95QI7-5]
NP_001024605.1, NM_001029434.2 [Q95QI7-6]
NP_001300341.1, NM_001313412.1 [Q95QI7-2]
NP_001300342.1, NM_001313413.1 [Q95QI7-4]
NP_001300343.1, NM_001313414.1 [Q95QI7-3]
NP_001300344.1, NM_001313415.1 [Q95QI7-7]
NP_001300345.1, NM_001313416.1
NP_001300346.1, NM_001313417.1 [Q95QI7-9]
NP_508161.3, NM_075760.4 [Q95QI7-1]

3D structure databases

SMRiQ95QI7
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-26559N
IntActiQ95QI7, 15 interactors
STRINGi6239.F25E2.5a

Proteomic databases

EPDiQ95QI7
PaxDbiQ95QI7

Genome annotation databases

EnsemblMetazoaiF25E2.5a.1; F25E2.5a.1; WBGene00000899 [Q95QI7-1]
F25E2.5b.1; F25E2.5b.1; WBGene00000899 [Q95QI7-5]
F25E2.5c.1; F25E2.5c.1; WBGene00000899 [Q95QI7-6]
F25E2.5d.1; F25E2.5d.1; WBGene00000899 [Q95QI7-2]
F25E2.5e.1; F25E2.5e.1; WBGene00000899 [Q95QI7-4]
F25E2.5f.1; F25E2.5f.1; WBGene00000899 [Q95QI7-3]
F25E2.5g.1; F25E2.5g.1; WBGene00000899 [Q95QI7-7]
F25E2.5g.2; F25E2.5g.2; WBGene00000899 [Q95QI7-7]
F25E2.5h.1; F25E2.5h.1; WBGene00000899 [Q95QI7-8]
F25E2.5h.2; F25E2.5h.2; WBGene00000899 [Q95QI7-8]
F25E2.5i.1; F25E2.5i.1; WBGene00000899 [Q95QI7-9]
GeneIDi180431
KEGGicel:CELE_F25E2.5
UCSCiF25E2.5c, c. elegans [Q95QI7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180431
WormBaseiF25E2.5a ; CE28002 ; WBGene00000899 ; daf-3
F25E2.5b ; CE30963 ; WBGene00000899 ; daf-3
F25E2.5c ; CE26364 ; WBGene00000899 ; daf-3
F25E2.5d ; CE50706 ; WBGene00000899 ; daf-3
F25E2.5e ; CE50732 ; WBGene00000899 ; daf-3
F25E2.5f ; CE28003 ; WBGene00000899 ; daf-3
F25E2.5g ; CE50852 ; WBGene00000899 ; daf-3
F25E2.5h ; CE50691 ; WBGene00000899 ; daf-3
F25E2.5i ; CE50737 ; WBGene00000899 ; daf-3

Phylogenomic databases

eggNOGiKOG3701, Eukaryota
HOGENOMiCLU_323960_0_0_1
InParanoidiQ95QI7
OMAiCKHAFEM
OrthoDBi949229at2759
PhylomeDBiQ95QI7

Gene expression databases

BgeeiWBGene00000899, Expressed in material anatomical entity and 5 other tissues
ExpressionAtlasiQ95QI7, baseline and differential

Family and domain databases

Gene3Di2.60.200.10, 1 hit
3.90.520.10, 1 hit
InterProiView protein in InterPro
IPR013790, Dwarfin
IPR003619, MAD_homology1_Dwarfin-type
IPR013019, MAD_homology_MH1
IPR017855, SMAD-like_dom_sf
IPR001132, SMAD_dom_Dwarfin-type
IPR008984, SMAD_FHA_dom_sf
IPR036578, SMAD_MH1_sf
PANTHERiPTHR13703, PTHR13703, 1 hit
PfamiView protein in Pfam
PF03165, MH1, 1 hit
PF03166, MH2, 1 hit
SMARTiView protein in SMART
SM00523, DWA, 1 hit
SM00524, DWB, 1 hit
SUPFAMiSSF49879, SSF49879, 1 hit
SSF56366, SSF56366, 1 hit
PROSITEiView protein in PROSITE
PS51075, MH1, 1 hit
PS51076, MH2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDAF3_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q95QI7
Secondary accession number(s): A0A0K3ASQ1
, A0A0K3ATA0, A0A0K3AVK9, A0A0K3AVL3, A0A0K3AWB3, A0A0K3AYJ4, O17532, Q95QI8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 7, 2021
Last sequence update: December 1, 2001
Last modified: June 2, 2021
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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