Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 139 (12 Aug 2020)
Sequence version 2 (20 Dec 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

RNA polymerase II subunit A C-terminal domain phosphatase

Gene

fcp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

During the late stages of oogenesis, dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit ama-1 (PubMed:17291483). Similarly, dephosphorylates 'Ser-5' of ama-1 in early embryonic cells prior to the activation of the zygotic transcription program at the 4-cell embryonic stage (PubMed:17291483). May dephosphorylate 'Ser-2' of the ama-1 heptad repeats YSPTSPS in embryonic somatic and germline cells (PubMed:23903194).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA polymerase II CTD heptapeptide repeat phosphatase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processDifferentiation, Oogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-112382, Formation of RNA Pol II elongation complex
R-CEL-113418, Formation of the Early Elongation Complex
R-CEL-674695, RNA Polymerase II Pre-transcription Events
R-CEL-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-CEL-75955, RNA Polymerase II Transcription Elongation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q95QG8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphataseBy similarity (EC:3.1.3.162 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fcp-1Imported
ORF Names:F36F2.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
F36F2.6 ; CE39366 ; WBGene00009479 ; fcp-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown causes an arrest at the 100-cell embryonic stage (PubMed:17291483). In developing oocytes, results in an abnormal accumulation of 'Ser-5' phosphorylated ama-1 and a more diffused nuclear localization of phosphorylated ama-1 (PubMed:17291483). 'Ser-2' phosphorylated ama-1 is present in diakinetic oocyte but at low levels indicating that transcription is possibly blocked at the elongation stage (PubMed:17291483). Increased levels of 'Ser-2' phosphorylated ama-1 in embryonic and germline nuclei (PubMed:23903194). Simultaneous knockdown of components of the transcription pre-initiation complex including ama-1, rbp-2, cdk-7, rgr-1 or taf-4 abolishes phosphorylation of the ama-1 CTD domain repeats at 'Ser-5' in diakinetic oocytes (PubMed:17291483). A similar abnormal accumulation of 'Ser-5' phosphorylated ama-1 occurs in 1-cell and 2-cell embryos (PubMed:17291483).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004435291 – 659RNA polymerase II subunit A C-terminal domain phosphataseAdd BLAST659

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q95QG8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q95QG8

PeptideAtlas

More...
PeptideAtlasi
Q95QG8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00009479, Expressed in adult organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F36F2.6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q95QG8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini139 – 303FCP1 homologyPROSITE-ProRule annotationAdd BLAST165
Domaini351 – 443BRCTPROSITE-ProRule annotationAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi482 – 658Asp-richPROSITE-ProRule annotationAdd BLAST177

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0323, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015641

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007683_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q95QG8

KEGG Orthology (KO)

More...
KOi
K15732

Identification of Orthologs from Complete Genome Data

More...
OMAi
PLLHMQE

Database of Orthologous Groups

More...
OrthoDBi
683531at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q95QG8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1000, 1 hit
3.40.50.10190, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR039189, Fcp1
IPR004274, FCP1_dom
IPR011947, FCP1_euk
IPR036412, HAD-like_sf
IPR023214, HAD_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23081, PTHR23081, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00533, BRCT, 1 hit
PF03031, NIF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292, BRCT, 1 hit
SM00577, CPDc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52113, SSF52113, 1 hit
SSF56784, SSF56784, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02250, FCP1_euk, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172, BRCT, 1 hit
PS50969, FCP1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q95QG8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIKFEGNDA ECTAGLKKAS EGSFVLKDHV LIEFKINGKV AGKIKTPCEG
60 70 80 90 100
VVTFGKGLKP GIVLNKGQVI ATVSECTHAI VIKDMCATCG KDLREKGGRA
110 120 130 140 150
GQRKEQSTAN VSMIHHVPEL IVSDTLAKEI GSADENNLIT NRKLVLLVDL
160 170 180 190 200
DQTIIHTSDK PMTVDTENHK DITKYNLHSR VYTTKLRPHT TEFLNKMSNM
210 220 230 240 250
YEMHIVTYGQ RQYAHRIAQI LDPDARLFEQ RILSRDELFS AQHKTNNLKA
260 270 280 290 300
LFPCGDNLVV IIDDRSDVWM YSEALIQIKP YRFFKEVGDI NAPKNSKEQM
310 320 330 340 350
PVQIEDDAHE DKVLEEIERV LTNIHDKYYE KHDLRGSEEV LLDVKEVIKE
360 370 380 390 400
ERHKVLDGCV IVFSGIVPMG EKLERTDIYR LCTQFGAVIV PDVTDDVTHV
410 420 430 440 450
VGARYGTQKV YQANRLNKFV VTVQWVYACV EKWLKADENL FQLTKESTPP
460 470 480 490 500
VGRPLGSKYV NDLANMDTIG KAALADMNNE VDEALSDDED DGDNEDEDDD
510 520 530 540 550
GNDVGEDKGD ENLEEKQEKN EEEMDDVEQN GSVENQSGDA LENETDSTSR
560 570 580 590 600
GQKRKHCPEM EDEEEESDSD NEDDDTPMSY KALLSDSRKK GRIVPENEDD
610 620 630 640 650
AVFDVDDEKG HAPANIDEEE DDEDNEDEEV PESDDDDEFE DMAALIERQI

SDAVDEKDQ
Length:659
Mass (Da):74,412
Last modified:December 20, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5AC5F46EF102F70
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAC70088.2

NCBI Reference Sequences

More...
RefSeqi
NP_492423.2, NM_060022.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F36F2.6.1; F36F2.6.1; WBGene00009479

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172719

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F36F2.6

UCSC genome browser

More...
UCSCi
F36F2.6, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAC70088.2
RefSeqiNP_492423.2, NM_060022.4

3D structure databases

SMRiQ95QG8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.F36F2.6

Proteomic databases

EPDiQ95QG8
PaxDbiQ95QG8
PeptideAtlasiQ95QG8

Genome annotation databases

EnsemblMetazoaiF36F2.6.1; F36F2.6.1; WBGene00009479
GeneIDi172719
KEGGicel:CELE_F36F2.6
UCSCiF36F2.6, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172719
WormBaseiF36F2.6 ; CE39366 ; WBGene00009479 ; fcp-1

Phylogenomic databases

eggNOGiKOG0323, Eukaryota
GeneTreeiENSGT00390000015641
HOGENOMiCLU_007683_1_1_1
InParanoidiQ95QG8
KOiK15732
OMAiPLLHMQE
OrthoDBi683531at2759
PhylomeDBiQ95QG8

Enzyme and pathway databases

ReactomeiR-CEL-112382, Formation of RNA Pol II elongation complex
R-CEL-113418, Formation of the Early Elongation Complex
R-CEL-674695, RNA Polymerase II Pre-transcription Events
R-CEL-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-CEL-75955, RNA Polymerase II Transcription Elongation
SignaLinkiQ95QG8

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q95QG8

Gene expression databases

BgeeiWBGene00009479, Expressed in adult organism and 5 other tissues

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR039189, Fcp1
IPR004274, FCP1_dom
IPR011947, FCP1_euk
IPR036412, HAD-like_sf
IPR023214, HAD_sf
PANTHERiPTHR23081, PTHR23081, 1 hit
PfamiView protein in Pfam
PF00533, BRCT, 1 hit
PF03031, NIF, 1 hit
SMARTiView protein in SMART
SM00292, BRCT, 1 hit
SM00577, CPDc, 1 hit
SUPFAMiSSF52113, SSF52113, 1 hit
SSF56784, SSF56784, 1 hit
TIGRFAMsiTIGR02250, FCP1_euk, 1 hit
PROSITEiView protein in PROSITE
PS50172, BRCT, 1 hit
PS50969, FCP1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFCP1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q95QG8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2018
Last sequence update: December 20, 2005
Last modified: August 12, 2020
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again