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Entry version 113 (11 Dec 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Inositol-trisphosphate 3-kinase homolog

Gene

lfe-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably by regulating inositol 1,4,5-trisphosphate levels, negatively regulates posterior body wall muscle contractions required for defecation and let-23 signaling pathway that controls spermathecal dilation and ovulation (PubMed:9491893, PubMed:16186564). May also regulate ovulation downstream of actin cross-linker fln-1 (PubMed:23671426).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Unlike mammalian IP3K, may not be regulated by calmodulin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei206ATPBy similarity1
Binding sitei218ATPBy similarity1
Binding sitei276ATPBy similarity1
Binding sitei278SubstrateBy similarity1
Binding sitei346ATPBy similarity1
Binding sitei426ATPBy similarity1
Binding sitei429SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi260 – 262ATPBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1855204 Synthesis of IP3 and IP4 in the cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol-trisphosphate 3-kinase homologCurated (EC:2.7.1.1271 Publication)
Alternative name(s):
Inositol 1,4,5-trisphosphate 3-kinase homolog1 Publication
Short name:
IP3 3-kinaseCurated
Short name:
IP3KCurated
Short name:
InsP 3-kinaseCurated
let-23 fertility effector 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lfe-2Imported
ORF Names:C46H11.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
C46H11.4a ; CE27862 ; WBGene00002979 ; lfe-2
C46H11.4b ; CE27863 ; WBGene00002979 ; lfe-2
C46H11.4c ; CE27864 ; WBGene00002979 ; lfe-2
C46H11.4d ; CE43466 ; WBGene00002979 ; lfe-2
C46H11.4e ; CE43449 ; WBGene00002979 ; lfe-2
C46H11.4f ; CE52138 ; WBGene00002979 ; lfe-2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004379811 – 494Inositol-trisphosphate 3-kinase homologCuratedAdd BLAST494

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q95Q62

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q95Q62

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in spermatheca.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00002979 Expressed in 4 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q95Q62, 1 interactor

Molecular INTeraction database

More...
MINTi
Q95Q62

STRING: functional protein association networks

More...
STRINGi
6239.C46H11.4a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q95Q62

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni322 – 329Substrate bindingBy similarity8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1621 Eukaryota
ENOG410Y8AC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000173539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231765

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q95Q62

KEGG Orthology (KO)

More...
KOi
K00911

Identification of Orthologs from Complete Genome Data

More...
OMAi
FGFNDPH

Database of Orthologous Groups

More...
OrthoDBi
966687at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q95Q62

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.510.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12400 PTHR12400, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03770 IPK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: Q95Q62-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHTQPQSYQA PEQTHMRIEN RRIEAGKGGT NLLLIIESRV DTLSINLPTL
60 70 80 90 100
YSLLFTTNIT ILMSAPQHRQ LRRAAHITKI ASIDLCSLEE EDHEDLVLEE
110 120 130 140 150
SGHHPSDIQN EKPNRPPYST LIRKRSGKVF RFVRPKLADL WHSRYHEASF
160 170 180 190 200
DLGRRLGIGR RTQSCCEDVC DEEVSVETMA ITALPMDVWL KERLKKWVQL
210 220 230 240 250
SGHEGSIVPA TPHTLYKKQC ANCGEGRAYK NISKDPALDG FTPKYYDELE
260 270 280 290 300
KNEEHFIEIE DLLQQFHDPT KTAIMDIKIG TRTFLESEVS NTKKRADLYE
310 320 330 340 350
KMVAIDNDEP TEEERKCGAI TKLRYMQFRE RESSTAQLGF RIEAAKRLEG
360 370 380 390 400
ALEKNFKKVR TVEDVTTTFM DFFGTQRSRV RQQLIERLKS MRKAIEHSSF
410 420 430 440 450
FNSHEVVGSS ILIVFDTEKV GCWMIDFAKS SPVPNGRTLN HRTTWIPGNN
460 470 480 490
EDGYLIGIDN LVKILEELPE YGEHPDDQLM VTEEVIARMK NTKS
Length:494
Mass (Da):56,840
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F1EBEC9F0359A29
GO
Isoform bImported (identifier: Q95Q62-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: MHTQPQSYQA...SCCEDVCDEE → MTTLFEKLAE...FCDAFGKLVQ

Show »
Length:394
Mass (Da):45,215
Checksum:i83271B23FA73B4DE
GO
Isoform cImported (identifier: Q95Q62-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: MHTQPQSYQA...SCCEDVCDEE → MLEAIYAKIM...FCDAFGKLVQ

Show »
Length:461
Mass (Da):52,765
Checksum:iA0FEC90E44B9536D
GO
Isoform dImported (identifier: Q95Q62-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: MHTQPQSYQA...SCCEDVCDEE → MCLMSNVECK...FCDAFGKLVQ

Show »
Length:449
Mass (Da):51,443
Checksum:iA83A2E9FB1200A77
GO
Isoform eImported (identifier: Q95Q62-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-173: HTQPQSYQAP...SCCEDVCDEE → SLSNRVRAHL...FCDAFGKLVQ

Show »
Length:474
Mass (Da):54,367
Checksum:i06C7A0E5286C159C
GO
Isoform fImported (identifier: Q95Q62-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: MHTQPQSYQA...SCCEDVCDEE → MNYAHSASEK...FCDAFGKLVQ

Show »
Length:458
Mass (Da):52,484
Checksum:i20EF617C328EBE24
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti488R → T in AAC38960 (PubMed:9491893).Curated1
Sequence conflicti488R → T in AAC38961 (PubMed:9491893).Curated1
Sequence conflicti488R → T in AAC38962 (PubMed:9491893).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0585821 – 173MHTQP…VCDEE → MTTLFEKLAELMLMDTDKYS PQKSRLFKRMAANIISCFPY PTTRPASPQCLPKPSPESCE HRAFCDAFGKLVQ in isoform b. CuratedAdd BLAST173
Alternative sequenceiVSP_0585831 – 173MHTQP…VCDEE → MLEAIYAKIMGVGTSRHDKR QGCWSWGGSSNSEEKRMKRP KKLPSKLRLKISGNQRRRRD DTFVVWEEIPTPSVCDHRDT MNSEASSSPPSAPTQERLMQ IISCFPYPTTRPASPQCLPK PSPESCEHRAFCDAFGKLVQ in isoform c. CuratedAdd BLAST173
Alternative sequenceiVSP_0585841 – 173MHTQP…VCDEE → MCLMSNVECKEVVNCNSSNS EEKRMKRPKKLPSKLRLKIS GNQRRRRDDTFVVWEEIPTP SVCDHRDTMNSEASSSPPSA PTQERLMQIISCFPYPTTRP ASPQCLPKPSPESCEHRAFC DAFGKLVQ in isoform d. CuratedAdd BLAST173
Alternative sequenceiVSP_0585851 – 173MHTQP…VCDEE → MNYAHSASEKKSENKTLKKK GHIARSSNSEEKRMKRPKKL PSKLRLKISGNQRRRRDDTF VVWEEIPTPSVCDHRDTMNS EASSSPPSAPTQERLMQIIS CFPYPTTRPASPQCLPKPSP ESCEHRAFCDAFGKLVQ in isoform f. CuratedAdd BLAST173
Alternative sequenceiVSP_0585862 – 173HTQPQ…VCDEE → SLSNRVRAHLVRSLLYIYTF IMGVGTSRHDKRQGCWSWGG SSNSEEKRMKRPKKLPSKLR LKISGNQRRRRDDTFVVWEE IPTPSVCDHRDTMNSEASSS PPSAPTQERLMQIISCFPYP TTRPASPQCLPKPSPESCEH RAFCDAFGKLVQ in isoform e. CuratedAdd BLAST172

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF045611 mRNA Translation: AAC38960.1
AF045612 mRNA Translation: AAC38961.1
AF045613 mRNA Translation: AAC38962.1
BX284601 Genomic DNA Translation: CCD66218.1
BX284601 Genomic DNA Translation: CCD66219.1
BX284601 Genomic DNA Translation: CCD66220.1
BX284601 Genomic DNA Translation: CCD66228.1
BX284601 Genomic DNA Translation: CCD66229.1
BX284601 Genomic DNA Translation: CCD66230.1

Protein sequence database of the Protein Information Resource

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PIRi
T42444
T42512
T42513

NCBI Reference Sequences

More...
RefSeqi
NP_001021047.1, NM_001025876.3 [Q95Q62-1]
NP_001021048.1, NM_001025877.5 [Q95Q62-2]
NP_001021049.1, NM_001025878.5 [Q95Q62-3]
NP_001249776.1, NM_001262847.1 [Q95Q62-4]
NP_001249778.1, NM_001262849.1 [Q95Q62-5]
NP_001249779.1, NM_001262850.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C46H11.4a.1; C46H11.4a.1; WBGene00002979 [Q95Q62-1]
C46H11.4b.1; C46H11.4b.1; WBGene00002979 [Q95Q62-2]
C46H11.4c.1; C46H11.4c.1; WBGene00002979 [Q95Q62-3]
C46H11.4d.1; C46H11.4d.1; WBGene00002979 [Q95Q62-4]
C46H11.4e.1; C46H11.4e.1; WBGene00002979 [Q95Q62-5]
C46H11.4f.1; C46H11.4f.1; WBGene00002979

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172128

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C46H11.4

UCSC genome browser

More...
UCSCi
C46H11.4c c. elegans [Q95Q62-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045611 mRNA Translation: AAC38960.1
AF045612 mRNA Translation: AAC38961.1
AF045613 mRNA Translation: AAC38962.1
BX284601 Genomic DNA Translation: CCD66218.1
BX284601 Genomic DNA Translation: CCD66219.1
BX284601 Genomic DNA Translation: CCD66220.1
BX284601 Genomic DNA Translation: CCD66228.1
BX284601 Genomic DNA Translation: CCD66229.1
BX284601 Genomic DNA Translation: CCD66230.1
PIRiT42444
T42512
T42513
RefSeqiNP_001021047.1, NM_001025876.3 [Q95Q62-1]
NP_001021048.1, NM_001025877.5 [Q95Q62-2]
NP_001021049.1, NM_001025878.5 [Q95Q62-3]
NP_001249776.1, NM_001262847.1 [Q95Q62-4]
NP_001249778.1, NM_001262849.1 [Q95Q62-5]
NP_001249779.1, NM_001262850.1

3D structure databases

SMRiQ95Q62
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ95Q62, 1 interactor
MINTiQ95Q62
STRINGi6239.C46H11.4a

Proteomic databases

EPDiQ95Q62
PaxDbiQ95Q62

Genome annotation databases

EnsemblMetazoaiC46H11.4a.1; C46H11.4a.1; WBGene00002979 [Q95Q62-1]
C46H11.4b.1; C46H11.4b.1; WBGene00002979 [Q95Q62-2]
C46H11.4c.1; C46H11.4c.1; WBGene00002979 [Q95Q62-3]
C46H11.4d.1; C46H11.4d.1; WBGene00002979 [Q95Q62-4]
C46H11.4e.1; C46H11.4e.1; WBGene00002979 [Q95Q62-5]
C46H11.4f.1; C46H11.4f.1; WBGene00002979
GeneIDi172128
KEGGicel:CELE_C46H11.4
UCSCiC46H11.4c c. elegans [Q95Q62-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172128
WormBaseiC46H11.4a ; CE27862 ; WBGene00002979 ; lfe-2
C46H11.4b ; CE27863 ; WBGene00002979 ; lfe-2
C46H11.4c ; CE27864 ; WBGene00002979 ; lfe-2
C46H11.4d ; CE43466 ; WBGene00002979 ; lfe-2
C46H11.4e ; CE43449 ; WBGene00002979 ; lfe-2
C46H11.4f ; CE52138 ; WBGene00002979 ; lfe-2

Phylogenomic databases

eggNOGiKOG1621 Eukaryota
ENOG410Y8AC LUCA
GeneTreeiENSGT00940000173539
HOGENOMiHOG000231765
InParanoidiQ95Q62
KOiK00911
OMAiFGFNDPH
OrthoDBi966687at2759
PhylomeDBiQ95Q62

Enzyme and pathway databases

ReactomeiR-CEL-1855204 Synthesis of IP3 and IP4 in the cytosol

Miscellaneous databases

Protein Ontology

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PROi
PR:Q95Q62

Gene expression databases

BgeeiWBGene00002979 Expressed in 4 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di1.10.510.50, 1 hit
InterProiView protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf
PANTHERiPTHR12400 PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770 IPK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIP3KH_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q95Q62
Secondary accession number(s): H2KZ42
, H2KZ43, H2KZ45, H2KZ46, H2KZ47, O45049, O45050, O45051
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: December 1, 2001
Last modified: December 11, 2019
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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