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UniProtKB - Q95PW9 (Q95PW9_CAEEL)
Protein
Submitted name:
NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family
Gene
nck-1
Organism
Caenorhabditis elegans
Status
Functioni
GO - Molecular functioni
- kinase activity Source: UniProtKB-KW
- receptor tyrosine kinase binding Source: GO_Central
- signaling adaptor activity Source: GO_Central
GO - Biological processi
- cell migration Source: GO_Central
- signal transduction Source: GO_Central
Keywordsi
Molecular function | KinaseImported, Transferase |
Names & Taxonomyi
Protein namesi | Submitted name: NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein familyImported |
Gene namesi | Name:nck-1Imported ORF Names:CELE_ZK470.5Imported, ZK470.5Imported |
Organismi | Caenorhabditis elegansImported |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | ZK470.5a ; CE31270 ; WBGene00006410 ; nck-1 |
Subcellular locationi
Expressioni
Gene expression databases
Bgeei | WBGene00006410, Expressed in multi-cellular organism and 5 other tissues |
ExpressionAtlasi | Q95PW9, baseline and differential |
Interactioni
GO - Molecular functioni
- receptor tyrosine kinase binding Source: GO_Central
Protein-protein interaction databases
IntActi | Q95PW9, 32 interactors |
STRINGi | 6239.ZK470.5a |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 60 | SH3InterPro annotationAdd BLAST | 60 | |
Domaini | 114 – 174 | SH3InterPro annotationAdd BLAST | 61 | |
Domaini | 211 – 273 | SH3InterPro annotationAdd BLAST | 63 | |
Domaini | 301 – 393 | SH2InterPro annotationAdd BLAST | 93 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 13 – 33 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG4226, Eukaryota |
GeneTreei | ENSGT00940000167681 |
HOGENOMi | CLU_025160_0_0_1 |
InParanoidi | Q95PW9 |
OMAi | TWYYGAI |
OrthoDBi | 1097449at2759 |
PhylomeDBi | Q95PW9 |
Family and domain databases
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR017304, NCK IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF00018, SH3_1, 2 hits PF14604, SH3_9, 1 hit |
PIRSFi | PIRSF037874, Cytoplasmic_NCK, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 3 hits |
SUPFAMi | SSF50044, SSF50044, 3 hits SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50002, SH3, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q95PW9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEDYVVVKY DYLAQEEQEL TIKKNERLKL LDDSKNWWKV MNDSNSVGFV
60 70 80 90 100
PSNYVRKESI VDKAKGTIKG LARGRNRSSD PEPEERLNGI ARLAFSLNNN
110 120 130 140 150
CAVTPSSNKI PMMSSKTKAV VKFTYEPRLE DELGLTKGDF VYVVEKSTDG
160 170 180 190 200
WWKGEAPNGG VGWFPSNYVE EVEASTNGNQ GSIENRNPAA AAVPAPIMMQ
210 220 230 240 250
APPPKLQASR SSFEVVVALY SFDASSSEEL SFKKGERLEI VDHPEHDPDW
260 270 280 290 300
WMARNASGTT GLVPRNYIEV VNDSSSSKAS HQDFAPQYSG NGEIPMEQQP
310 320 330 340 350
WYFGRISRER AEDLLLHGRE GEFLVRDSES NPGDLSISMR GIERNKHFKV
360 370 380 390
QNVDGLLKIG NRTFVDMNAL INHYTTSPIF SSPTEKLFLT GPLPK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ95PX0 | Q95PX0_CAEEL | NCK (Non-Catalytic region of tyrosi... | nck-1 CELE_ZK470.5, ZK470.5 | 397 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284606 Genomic DNA Translation: CCD69109.1 |
RefSeqi | NP_508706.2, NM_076305.5 |
Genome annotation databases
EnsemblMetazoai | ZK470.5a.1; ZK470.5a.1; WBGene00006410 |
GeneIDi | 180690 |
KEGGi | cel:CELE_ZK470.5 |
UCSCi | ZK470.5b.3, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284606 Genomic DNA Translation: CCD69109.1 |
RefSeqi | NP_508706.2, NM_076305.5 |
3D structure databases
SMRi | Q95PW9 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q95PW9, 32 interactors |
STRINGi | 6239.ZK470.5a |
Proteomic databases
EPDi | Q95PW9 |
PaxDbi | Q95PW9 |
PeptideAtlasi | Q95PW9 |
Genome annotation databases
EnsemblMetazoai | ZK470.5a.1; ZK470.5a.1; WBGene00006410 |
GeneIDi | 180690 |
KEGGi | cel:CELE_ZK470.5 |
UCSCi | ZK470.5b.3, c. elegans |
Organism-specific databases
CTDi | 180690 |
WormBasei | ZK470.5a ; CE31270 ; WBGene00006410 ; nck-1 |
Phylogenomic databases
eggNOGi | KOG4226, Eukaryota |
GeneTreei | ENSGT00940000167681 |
HOGENOMi | CLU_025160_0_0_1 |
InParanoidi | Q95PW9 |
OMAi | TWYYGAI |
OrthoDBi | 1097449at2759 |
PhylomeDBi | Q95PW9 |
Gene expression databases
Bgeei | WBGene00006410, Expressed in multi-cellular organism and 5 other tissues |
ExpressionAtlasi | Q95PW9, baseline and differential |
Family and domain databases
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR017304, NCK IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF00018, SH3_1, 2 hits PF14604, SH3_9, 1 hit |
PIRSFi | PIRSF037874, Cytoplasmic_NCK, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 3 hits |
SUPFAMi | SSF50044, SSF50044, 3 hits SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50002, SH3, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q95PW9_CAEEL | |
Accessioni | Q95PW9Primary (citable) accession number: Q95PW9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 1, 2001 |
Last sequence update: | October 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |