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UniProtKB - Q95PM0 (Q95PM0_TRYBR)
Protein
Submitted name:
Cysteine protease
Gene
rhodesain
Organism
Trypanosoma brucei rhodesiense
Status
Functioni
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseARBA annotation |
Enzyme and pathway databases
BRENDAi | 3.4.22.15, 6522 |
Protein family/group databases
MEROPSi | C01.072 |
Names & Taxonomyi
Protein namesi | Submitted name: Cysteine proteaseImported |
Gene namesi | Name:rhodesainImported |
Organismi | Trypanosoma brucei rhodesienseImported |
Taxonomic identifieri | 31286 [NCBI] |
Taxonomic lineagei | Eukaryota › Discoba › Euglenozoa › Kinetoplastea › Metakinetoplastina › Trypanosomatida › Trypanosomatidae › Trypanosoma › |
PTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 147 ↔ 188 | Combined sources | ||
Disulfide bondi | 181 ↔ 226 | Combined sources | ||
Disulfide bondi | 280 ↔ 328 | Combined sources |
Keywords - PTMi
GlycoproteinARBA annotationStructurei
3D structure databases
SMRi | Q95PM0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q95PM0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 97 | Inhibitor_I29InterPro annotationAdd BLAST | 57 | |
Domaini | 126 – 338 | Pept_C1InterPro annotationAdd BLAST | 213 |
Sequence similaritiesi
Belongs to the peptidase C1 family.ARBA annotation
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR021981, DUF3586 IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
Pfami | View protein in Pfam PF12131, DUF3586, 1 hit PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q95PM0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRTEMVRFV RLPVVLLAMA ACLASVALGS LHVEESLEMR FAAFKKKYGK
60 70 80 90 100
VYKDAKEEAF RFRAFEENME QAKIQAAANP YATFGVTPFS DMTREEFRAR
110 120 130 140 150
YRNGASYFAA AQKRLRKTVN VTTGRAPAAV DWREKGAVTP VKDQGQCGSC
160 170 180 190 200
WAFSTIGNIE GQWQVAGNPL VSLSEQMLVS CDTIDFGCGG GLMDNAFNWI
210 220 230 240 250
VNSNGGNVFT EASYPYVSGN GEQPQCQMNG HEIGAAITDH VDLPQDEDAI
260 270 280 290 300
AAYLAENGPL AIAVDATSFM DYNGGILTSC TSEQLDHGVL LVGYNDSSNP
310 320 330 340 350
PYWIIKNSWS NMWGEDGYIR IEKGTNQCLM NQAVSSAVVG GPTPPPPPPP
360 370 380 390 400
PPSATFTQDF CEGKGCTKGC SHATFPTGEC VQTTGVGSVI ATCGASNLTQ
410 420 430 440 450
IIYPLSRSCS GLSVPITVPL DKCIPILIGS VEYHCSTNPP TKAARLVPHQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 450 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ297265 mRNA Translation: CAC67416.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ297265 mRNA Translation: CAC67416.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2P7U | X-ray | 1.65 | A | 126-340 | [»] | |
2P86 | X-ray | 1.16 | A | 126-340 | [»] | |
6EX8 | X-ray | 1.60 | A/B | 126-342 | [»] | |
6EXO | X-ray | 1.90 | A/B | 126-340 | [»] | |
6EXQ | X-ray | 2.50 | A/B | 126-340 | [»] | |
7AVM | X-ray | 2.80 | A | 21-342 | [»] | |
SMRi | Q95PM0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
BindingDBi | Q95PM0 |
ChEMBLi | CHEMBL4188 |
Protein family/group databases
MEROPSi | C01.072 |
Enzyme and pathway databases
BRENDAi | 3.4.22.15, 6522 |
Miscellaneous databases
EvolutionaryTracei | Q95PM0 |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR021981, DUF3586 IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
Pfami | View protein in Pfam PF12131, DUF3586, 1 hit PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q95PM0_TRYBR | |
Accessioni | Q95PM0Primary (citable) accession number: Q95PM0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 1, 2001 |
Last sequence update: | December 1, 2001 | |
Last modified: | June 2, 2021 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |