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Entry version 106 (26 Feb 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Pro-epidermal growth factor

Gene

EGF

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pro-epidermal growth factor
Short name:
EGF
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EGF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFelis catus (Cat) (Felis silvestris catus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9685 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000011712 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 1029ExtracellularSequence analysisAdd BLAST1007
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1030 – 1050HelicalSequence analysisAdd BLAST21
Topological domaini1051 – 1210CytoplasmicSequence analysisAdd BLAST160

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000753822 – 1210Pro-epidermal growth factorAdd BLAST1189
ChainiPRO_0000007539969 – 1020Epidermal growth factorBy similarityAdd BLAST52

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi316 ↔ 327PROSITE-ProRule annotation
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi322 ↔ 336PROSITE-ProRule annotation
Disulfide bondi338 ↔ 351PROSITE-ProRule annotation
Disulfide bondi357 ↔ 368PROSITE-ProRule annotation
Disulfide bondi364 ↔ 377PROSITE-ProRule annotation
Disulfide bondi379 ↔ 392PROSITE-ProRule annotation
Disulfide bondi398 ↔ 409PROSITE-ProRule annotation
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi405 ↔ 418PROSITE-ProRule annotation
Disulfide bondi420 ↔ 433PROSITE-ProRule annotation
Disulfide bondi436 ↔ 448PROSITE-ProRule annotation
Disulfide bondi444 ↔ 458PROSITE-ProRule annotation
Disulfide bondi460 ↔ 473PROSITE-ProRule annotation
Disulfide bondi742 ↔ 753PROSITE-ProRule annotation
Disulfide bondi749 ↔ 762PROSITE-ProRule annotation
Disulfide bondi764 ↔ 777PROSITE-ProRule annotation
Glycosylationi814N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi834 ↔ 845PROSITE-ProRule annotation
Disulfide bondi839 ↔ 854PROSITE-ProRule annotation
Glycosylationi851N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi856 ↔ 867PROSITE-ProRule annotation
Disulfide bondi873 ↔ 887PROSITE-ProRule annotation
Disulfide bondi880 ↔ 896PROSITE-ProRule annotation
Disulfide bondi898 ↔ 909PROSITE-ProRule annotation
Disulfide bondi915 ↔ 928PROSITE-ProRule annotation
Disulfide bondi922 ↔ 937PROSITE-ProRule annotation
Glycosylationi925N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi934N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi939 ↔ 950PROSITE-ProRule annotation
Disulfide bondi974 ↔ 988PROSITE-ProRule annotation
Disulfide bondi982 ↔ 999PROSITE-ProRule annotation
Disulfide bondi1001 ↔ 1010PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q95ND4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EGFR and promotes EGFR dimerization.

Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD) (By similarity).

Interacts with RHBDF2 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9685.ENSFCAP00000000470

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q95ND4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati86 – 127LDL-receptor class B 1Add BLAST42
Repeati128 – 169LDL-receptor class B 2Add BLAST42
Repeati170 – 211LDL-receptor class B 3Add BLAST42
Repeati212 – 258LDL-receptor class B 4Add BLAST47
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini312 – 352EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini353 – 393EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini394 – 434EGF-like 3PROSITE-ProRule annotationAdd BLAST41
Domaini432 – 474EGF-like 4PROSITE-ProRule annotationAdd BLAST43
Repeati480 – 520LDL-receptor class B 5Add BLAST41
Repeati521 – 563LDL-receptor class B 6Add BLAST43
Repeati564 – 606LDL-receptor class B 7Add BLAST43
Repeati607 – 650LDL-receptor class B 8Add BLAST44
Repeati651 – 693LDL-receptor class B 9Add BLAST43
Domaini738 – 778EGF-like 5PROSITE-ProRule annotationAdd BLAST41
Domaini830 – 868EGF-like 6PROSITE-ProRule annotationAdd BLAST39
Domaini869 – 910EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini911 – 951EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini970 – 1011EGF-like 9PROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPSY Eukaryota
ENOG410ZVIM LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q95ND4

KEGG Orthology (KO)

More...
KOi
K04357

Database of Orthologous Groups

More...
OrthoDBi
1174178at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR000033 LDLR_classB_rpt
IPR016317 Pro-epidermal_GF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662 cEGF, 1 hit
PF00008 EGF, 1 hit
PF07645 EGF_CA, 2 hits
PF00058 Ldl_recept_b, 4 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001778 Pro-epidermal_growth_factor, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 9 hits
SM00179 EGF_CA, 6 hits
SM00135 LY, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 3 hits
PS51120 LDLRB, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q95ND4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLFLIILLP VVFKFSFVSL SVLQGWDCSE GSSSGKGNST CVGPEPFLIF
60 70 80 90 100
SHGGSIFRID LDGTNYEQLV ADAGVSVIMD FHYYKERLYW VDLERQLLQR
110 120 130 140 150
VFLNGTRQET VCNIEKNVSG MAINWINEEL IWSNQQEGII TVTDMKGNNS
160 170 180 190 200
RVLLSALKYP ANVAIDPVER FIFWSSEVAG SLHRADLNGV EVKILLETSE
210 220 230 240 250
RITAVSLDVL DKRLFWIQNN RDGSNSYICS CNYDGGSVHF NKHLTQHSLF
260 270 280 290 300
AMSLFGDRIF YSTWKKKTIW IANKRKDMVR INLNPSFVPP GGTKVVHPLL
310 320 330 340 350
QPKAESDAWA PGQKLCLRKG NCTGSVCEQD SKSHLCTCAE GYTLSPDGKH
360 370 380 390 400
CEDVNECAFW NHGCTLGCEN IPGSYYCTCP VGFILLPDGK RCHQLISCPS
410 420 430 440 450
NTSKCSHDCV LTSDGPICFC PEGSVLETDG KTCSGCSSPD NGGCSQLCLP
460 470 480 490 500
LSPVSWECGC FPGYDLQLDK KSCAASGPQP FLLFANSQDI RHVRFDGTDY
510 520 530 540 550
GSLLSQQMGM VFALDHDPVE NKIYFAHTAL KWIERANMDG SQRERLIEEA
560 570 580 590 600
VDVPEGLAID WIDRKFYWTD RGKALIEGSD LNGKHREIII KEEVSQPRGI
610 620 630 640 650
AVHPMAKRLF WTDMGINPRI ESSSLQGIGR RVIASSDLVW PSGITIDYLT
660 670 680 690 700
DKLYWCDAKQ SVIEMANLDG SKRQRLAQND VGHPFAIAVF EDHVWFSDWT
710 720 730 740 750
MPSVIRVNKR TGKNRVRLRG SMLKPSSLVV VHPLAKPGSD PCLHQNGGCE
760 770 780 790 800
HICKERFGSA QCLCREGFVK APDGKMCLAL NGHQIPPAVG SEADLSNQVT
810 820 830 840 850
PLDVLSRNRG SEDNSTESQH MLVAEIMVSD NDDCGPIRCG TWGQCVSEGE
860 870 880 890 900
NATCQCLKGF TGDGKLCSDI NECGTSTTVC PPTSSKCINT EGGYVCQCSE
910 920 930 940 950
GYRGDGIHCL DIDECQLGIH TCGENATCTN TEGNYTCMCA GTLSEPGQMC
960 970 980 990 1000
PDSTPPSVLM EDGRYSVRNS YQECPPSYDG YCLYNGVCMY IEAVDRYACN
1010 1020 1030 1040 1050
CVFGYVGERC QHRDLKWELR HAGQGRQRQV TVVAVCVVAL VLLLLLGLWG
1060 1070 1080 1090 1100
AHCYRTKKLP SKNLKNPYEE SSREVSRPTD SEAGMASCPQ PWFVVIKEHQ
1110 1120 1130 1140 1150
NLRNGSQSMA LKDSEAADVS QFSSRETGSV QLPSRRNEPQ VYMGAEQGCC
1160 1170 1180 1190 1200
IPPSSDKGPG PHGMQWGFHL PSCEAQPIAL GVEKSQSLLS ANPILQQRAS
1210
DLPHQKKLTQ
Length:1,210
Mass (Da):133,640
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46EABA4C49886003
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB050947 mRNA Translation: BAB47391.1

NCBI Reference Sequences

More...
RefSeqi
NP_001009381.1, NM_001009381.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
493978

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
fca:493978

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050947 mRNA Translation: BAB47391.1
RefSeqiNP_001009381.1, NM_001009381.1

3D structure databases

SMRiQ95ND4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000000470

Proteomic databases

PRIDEiQ95ND4

Genome annotation databases

GeneIDi493978
KEGGifca:493978

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1950

Phylogenomic databases

eggNOGiENOG410IPSY Eukaryota
ENOG410ZVIM LUCA
InParanoidiQ95ND4
KOiK04357
OrthoDBi1174178at2759

Family and domain databases

Gene3Di2.120.10.30, 2 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR000033 LDLR_classB_rpt
IPR016317 Pro-epidermal_GF
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF00008 EGF, 1 hit
PF07645 EGF_CA, 2 hits
PF00058 Ldl_recept_b, 4 hits
PIRSFiPIRSF001778 Pro-epidermal_growth_factor, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 9 hits
SM00179 EGF_CA, 6 hits
SM00135 LY, 9 hits
SUPFAMiSSF57184 SSF57184, 3 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 3 hits
PS51120 LDLRB, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEGF_FELCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q95ND4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 1, 2001
Last modified: February 26, 2020
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
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