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Protein

Carboxylic ester hydrolase

Gene

CES1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-CFA-211945 Phase I - Functionalization of compounds

Protein family/group databases

ESTHERicanfa-CESDD1 Carb_B_Chordata

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic ester hydrolaseUniRule annotation (EC:3.1.1.-UniRule annotation)
Gene namesi
Name:CES1Imported
Synonyms:CESdD1Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:52121 CES1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18UniRule annotationAdd BLAST18
ChainiPRO_501521118519 – 565Carboxylic ester hydrolaseUniRule annotationAdd BLAST547

Expressioni

Gene expression databases

BgeeiENSCAFG00000009333 Expressed in 3 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000013746

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 545COesteraseInterPro annotationAdd BLAST522

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOGENOMiHOG000091866
HOVERGENiHBG008839
KOiK01044
OMAiDGMDYIN
OrthoDBiEOG091G03ZC
TreeFamiTF315470

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q95N05-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLFDLVLTS LATSMAWGYP SLPPVVDTVQ GKVLGKYVSL EGFAQPVAVF
60 70 80 90 100
LGVPFAKPPL GPLRFAPPQA AEPWNFVKNT TSYPPMCSQD AVGGQVLSEL
110 120 130 140 150
FTNRKDNIPL KFSEDCLYLN IYTPADLTKN SRLPVMVWIH GGGLVVGGAS
160 170 180 190 200
TYDGLALSAH ENVVVVTIQY RLGIWGFFST GDEHGRGNWG HLDQLAALRW
210 220 230 240 250
VQENIANFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF HRAISESGVA
260 270 280 290 300
LTAALVKKDM KDTAQQIAVF AGCKSTTSAV LVHCLRQKTE DELLEVSLKL
310 320 330 340 350
KFFTLDLFGD PRESYPFLPT VVDGVLLPKM PQEILAEKKF NSVPYIIGIN
360 370 380 390 400
KQEFGWLLPM MMGYPLSEDK LDQKTASSLL WKSYPIANIP EELTPLASEK
410 420 430 440 450
YLGGTDDPVK KKALFLDMLG DVVFGVPSVT VARHHRDAGA PTYMYEFQYH
460 470 480 490 500
PSFSSDMKPQ TVVGDHGDEL FSVFGAPFLK GGASEEEIRL SKMMMKLWAN
510 520 530 540 550
FARSGNPNGE GLPSWPAYDQ KEGYLQIGIP TQPAQKLKSK EMAFWTELLA
560
KRAAEKLSPT EHVEL
Length:565
Mass (Da):62,000
Last modified:December 1, 2001 - v1
Checksum:i905AA4222DEFD37B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03001588 Genomic DNA No translation available.
AB023629 mRNA Translation: BAB60696.1
RefSeqiNP_001003085.1, NM_001003085.1
UniGeneiCfa.3506

Genome annotation databases

EnsembliENSCAFT00000014854; ENSCAFP00000013746; ENSCAFG00000009333
GeneIDi403643
KEGGicfa:403643

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03001588 Genomic DNA No translation available.
AB023629 mRNA Translation: BAB60696.1
RefSeqiNP_001003085.1, NM_001003085.1
UniGeneiCfa.3506

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000013746

Protein family/group databases

ESTHERicanfa-CESDD1 Carb_B_Chordata

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000014854; ENSCAFP00000013746; ENSCAFG00000009333
GeneIDi403643
KEGGicfa:403643

Organism-specific databases

CTDi1066
VGNCiVGNC:52121 CES1

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOGENOMiHOG000091866
HOVERGENiHBG008839
KOiK01044
OMAiDGMDYIN
OrthoDBiEOG091G03ZC
TreeFamiTF315470

Enzyme and pathway databases

ReactomeiR-CFA-211945 Phase I - Functionalization of compounds

Gene expression databases

BgeeiENSCAFG00000009333 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ95N05_CANLF
AccessioniPrimary (citable) accession number: Q95N05
Secondary accession number(s): F1PQV5
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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