UniProtKB - Q95MI5 (NKG2A_PANTR)
Protein
NKG2-A/NKG2-B type II integral membrane protein
Gene
KLRC1
Organism
Pan troglodytes (Chimpanzee)
Status
Functioni
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
- MHC class I protein complex binding Source: Ensembl
Keywordsi
Molecular function | Receptor |
Ligand | Lectin |
Names & Taxonomyi
Protein namesi | Recommended name: NKG2-A/NKG2-B type II integral membrane proteinAlternative name(s): CD159 antigen-like family member A NK cell receptor A NKG2-A/B-activating NK receptor CD_antigen: CD159a |
Gene namesi | Name:KLRC1 Synonyms:NKG2A |
Organismi | Pan troglodytes (Chimpanzee) |
Taxonomic identifieri | 9598 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:8432, KLRC1 |
Subcellular locationi
Other locations
Other locations
- integral component of membrane Source: UniProtKB-KW
- receptor complex Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 70 | CytoplasmicSequence analysisAdd BLAST | 70 | |
Transmembranei | 71 – 93 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 23 | |
Topological domaini | 94 – 233 | ExtracellularSequence analysisAdd BLAST | 140 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046661 | 1 – 233 | NKG2-A/NKG2-B type II integral membrane proteinAdd BLAST | 233 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 116 | Interchain (with C-59 in KLRD1)PROSITE-ProRule annotation | ||
Disulfide bondi | 119 ↔ 130 | PROSITE-ProRule annotation | ||
Disulfide bondi | 147 ↔ 229 | PROSITE-ProRule annotation | ||
Glycosylationi | 180 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 208 ↔ 221 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q95MI5 |
Expressioni
Tissue specificityi
Natural killer cells.
Gene expression databases
Bgeei | ENSPTRG00000004676, Expressed in liver and 4 other tissues |
Interactioni
Subunit structurei
Can form disulfide-bonded heterodimer with CD94.
Protein-protein interaction databases
STRINGi | 9598.ENSPTRP00000054743 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 118 – 231 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 114 |
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S6IE, Eukaryota |
GeneTreei | ENSGT00940000164619 |
HOGENOMi | CLU_049894_9_2_1 |
InParanoidi | Q95MI5 |
OMAi | TMIVITP |
OrthoDBi | 1161111at2759 |
TreeFami | TF336674 |
Family and domain databases
CDDi | cd03593, CLECT_NK_receptors_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR033992, NKR-like_CTLD |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS50041, C_TYPE_LECTIN_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform NKG2-A (identifier: Q95MI5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDNQGVIYSD LNLPPNPKRQ QRKPKGNKSS ILATEQEITY AELNLQKASQ
60 70 80 90 100
DFQENDKTYH CKDLPSAPEK LIVGILGIIC LILMASVVTI VVIPSTLIQR
110 120 130 140 150
HNNSSLNTRT QKARHCGHCP EEWITYSNSC YYIGKERRTW EESLLACTSK
160 170 180 190 200
NSGLLSIDNE EEMKFLSIIS PSSWIGVFRN SSHHPWVTIN GLAFKHEIKD
210 220 230
SDNAELNCAV LQVNGLKSAQ CGSSIIYHCK HKL
Isoform NKG2-B (identifier: Q95MI5-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
96-113: Missing.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018698 | 79 | I → L in allele NKG2-A*03. 1 Publication | 1 | |
Natural variantiVAR_018699 | 231 | H → R in allele NKG2-A*03. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003066 | 96 – 113 | Missing in isoform NKG2-B. CuratedAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF259055 mRNA Translation: AAF86965.1 AF259056 mRNA Translation: AAF86966.1 AF350005 mRNA Translation: AAK83792.1 |
RefSeqi | NP_001009048.2, NM_001009048.2 [Q95MI5-1] XP_009423042.2, XM_009424767.2 [Q95MI5-1] |
Genome annotation databases
Ensembli | ENSPTRT00000062196; ENSPTRP00000054750; ENSPTRG00000029778 [Q95MI5-2] ENSPTRT00000067984; ENSPTRP00000059579; ENSPTRG00000029778 [Q95MI5-1] |
GeneIDi | 450131 |
KEGGi | ptr:450131 |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF259055 mRNA Translation: AAF86965.1 AF259056 mRNA Translation: AAF86966.1 AF350005 mRNA Translation: AAK83792.1 |
RefSeqi | NP_001009048.2, NM_001009048.2 [Q95MI5-1] XP_009423042.2, XM_009424767.2 [Q95MI5-1] |
3D structure databases
SMRi | Q95MI5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9598.ENSPTRP00000054743 |
Proteomic databases
PaxDbi | Q95MI5 |
Genome annotation databases
Ensembli | ENSPTRT00000062196; ENSPTRP00000054750; ENSPTRG00000029778 [Q95MI5-2] ENSPTRT00000067984; ENSPTRP00000059579; ENSPTRG00000029778 [Q95MI5-1] |
GeneIDi | 450131 |
KEGGi | ptr:450131 |
Organism-specific databases
CTDi | 3821 |
VGNCi | VGNC:8432, KLRC1 |
Phylogenomic databases
eggNOGi | ENOG502S6IE, Eukaryota |
GeneTreei | ENSGT00940000164619 |
HOGENOMi | CLU_049894_9_2_1 |
InParanoidi | Q95MI5 |
OMAi | TMIVITP |
OrthoDBi | 1161111at2759 |
TreeFami | TF336674 |
Gene expression databases
Bgeei | ENSPTRG00000004676, Expressed in liver and 4 other tissues |
Family and domain databases
CDDi | cd03593, CLECT_NK_receptors_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR033992, NKR-like_CTLD |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS50041, C_TYPE_LECTIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NKG2A_PANTR | |
Accessioni | Q95MI5Primary (citable) accession number: Q95MI5 Secondary accession number(s): Q9MYM6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2002 |
Last sequence update: | May 15, 2002 | |
Last modified: | December 2, 2020 | |
This is version 120 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |