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Protein

Liver-expressed antimicrobial peptide 2

Gene

LEAP2

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an antimicrobial activity.

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Liver-expressed antimicrobial peptide 2
Short name:
LEAP-2
Gene namesi
Name:LEAP2
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000001735723 – 37Add BLAST15
ChainiPRO_000001735838 – 77Liver-expressed antimicrobial peptide 2Add BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 65By similarity
Disulfide bondi60 ↔ 70By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Gene expression databases

BgeeiENSMMUG00000015638 Expressed in 14 organ(s), highest expression level in liver
ExpressionAtlasiQ95M25 baseline

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000020524

Structurei

3D structure databases

SMRiQ95M25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LEAP2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7PZ Eukaryota
ENOG410Y6EA LUCA
GeneTreeiENSGT00390000013467
HOGENOMiHOG000037938
HOVERGENiHBG052319
InParanoidiQ95M25

Family and domain databases

InterProiView protein in InterPro
IPR009955 LEAP-2
PANTHERiPTHR21007 PTHR21007, 1 hit
PfamiView protein in Pfam
PF07359 LEAP-2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q95M25-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWHLKLCAVL MIFLLLLGQT DGSPIPEVSS AKRRPRRMTP FWRGVSLRPI
60 70
GASCRDDSEC ITRLCRKRRC SLSVAQE
Length:77
Mass (Da):8,801
Last modified:December 1, 2001 - v1
Checksum:iFD012D0B125FE4C9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5QG40A0A1D5QG40_MACMU
Liver-expressed antimicrobial pepti...
LEAP2
87Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ409056 Genomic DNA Translation: CAC51520.1
RefSeqiNP_001107582.1, NM_001114110.1
UniGeneiMmu.17358

Genome annotation databases

EnsembliENSMMUT00000041106; ENSMMUP00000034142; ENSMMUG00000015638
GeneIDi709041
KEGGimcc:709041

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ409056 Genomic DNA Translation: CAC51520.1
RefSeqiNP_001107582.1, NM_001114110.1
UniGeneiMmu.17358

3D structure databases

SMRiQ95M25
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000020524

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000041106; ENSMMUP00000034142; ENSMMUG00000015638
GeneIDi709041
KEGGimcc:709041

Organism-specific databases

CTDi116842

Phylogenomic databases

eggNOGiENOG410J7PZ Eukaryota
ENOG410Y6EA LUCA
GeneTreeiENSGT00390000013467
HOGENOMiHOG000037938
HOVERGENiHBG052319
InParanoidiQ95M25

Gene expression databases

BgeeiENSMMUG00000015638 Expressed in 14 organ(s), highest expression level in liver
ExpressionAtlasiQ95M25 baseline

Family and domain databases

InterProiView protein in InterPro
IPR009955 LEAP-2
PANTHERiPTHR21007 PTHR21007, 1 hit
PfamiView protein in Pfam
PF07359 LEAP-2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLEAP2_MACMU
AccessioniPrimary (citable) accession number: Q95M25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: December 1, 2001
Last modified: October 10, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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