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Protein

Kinesin-like protein KIF2C

Gene

KIF2C

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi294 – 301ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF2C
Alternative name(s):
Mitotic centromere-associated kinesin
Short name:
MCAK
Gene namesi
Name:KIF2C
ORF Names:QtsA-16015
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254191 – 671Kinesin-like protein KIF2CAdd BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41Phosphoserine; by AURKBBy similarity1
Modified residuei52PhosphoserineBy similarity1
Modified residuei57PhosphoserineBy similarity1
Modified residuei61PhosphoserineBy similarity1
Modified residuei112PhosphoserineBy similarity1
Modified residuei121PhosphoserineBy similarity1
Modified residuei133PhosphoserineBy similarity1
Modified residuei138PhosphoserineBy similarity1
Disulfide bondi191 ↔ 233By similarity
Disulfide bondi290 ↔ 506By similarity
Modified residuei465PhosphoserineBy similarity1
Modified residuei567PhosphoserineBy similarity1
Modified residuei579PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.By similarity
Ubiquitinated.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein, Ubl conjugation

Interactioni

Subunit structurei

Interacts with CENPH. Interacts with MTUS2/TIP150; the interaction is direct. Interacts with MAPRE1; the interaction is direct, regulated by phosphorylation and is probably required for targeting to growing microtubule plus ends. Interacts with KIF18B at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. Phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ95LP1
SMRiQ95LP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini204 – 534Kinesin motorPROSITE-ProRule annotationAdd BLAST331

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 200GlobularSequence analysisAdd BLAST200
Regioni153 – 184Negative regulator of microtubule-bindingBy similarityAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili564 – 604Sequence analysisAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi44 – 47Microtubule tip localization signal4

Domaini

The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.By similarity

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00920000148953
HOVERGENiHBG003875
KOiK10393

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q95LP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDFDDVAAI NPELLQLLPL HPKDNLPLQE NVTIQKQKRR SVNSKIPAPK
60 70 80 90 100
ESLRTRSTRM STVSELRVTA QENDMEVELP AAANTRKQFS VPPTHPRPSC
110 120 130 140 150
PAVAEIPSRM VSEEVEEQVH SIRGSSSANP VNSVRRKSCI VKEVEKMKNK
160 170 180 190 200
REEKKAQNSE MRMKRAQEYD SSFPNWEFAR MIKEFRATLE CHPLTMTDPI
210 220 230 240 250
EEHRICVCVR KRPLNKQELA KKEIDVISIP SKCLLLVHEP KLKVDLTKYL
260 270 280 290 300
ENQAFCFDFA FDETASNEVV YRFTARPLVQ TIFEGGKATC FAYGQTGSGK
310 320 330 340 350
THTMGGDLSG KAQNASKGIY AMASRDVFLL KNQPCYRKLG LEVYVTFFEI
360 370 380 390 400
YNGKLFDLLN KKAKLRVLED GKQQVQVVGL QEHLVNSADD VIKMIDMGSA
410 420 430 440 450
CRTSGQTFAN SNSSRSHACF QILLRAKGRM HGKFSLVDLA GNERGADTSS
460 470 480 490 500
ADRQTRMEGA EINKSLLALK ECIRALGQNK AHTPFRESKL TQVLRDSFIG
510 520 530 540 550
ENSRTCMIAT ISPGISSCEY TLNTLRYADR VKELSPHSGP SGEQLIQMET
560 570 580 590 600
EEMEACSNGA LIPGNLSKEE EELSSQMSSF NEAMTQIREL EERAVEELKE
610 620 630 640 650
IIQQGPDWLE LSEMTEQPDY DLETFVNKAE FALAQQAKHF SALRDVIKAL
660 670
RLAMQLEEQA SRQISSKKRP Q
Length:671
Mass (Da):75,639
Last modified:December 1, 2001 - v1
Checksum:i4EAB399E8B6BBA46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072747 mRNA Translation: BAB69716.1
RefSeqiXP_005543633.1, XM_005543576.2
UniGeneiMfa.618

Genome annotation databases

EnsembliENSMFAT00000032667; ENSMFAP00000024527; ENSMFAG00000043842
GeneIDi102134753
KEGGimcf:102134753

Similar proteinsi

Entry informationi

Entry nameiKIF2C_MACFA
AccessioniPrimary (citable) accession number: Q95LP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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