UniProtKB - Q95LI8 (CD3D_MACFA)
T-cell surface glycoprotein CD3 delta chain
CD3D
Functioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
- transmembrane signaling receptor activity Source: InterPro
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- cell surface receptor signaling pathway Source: InterPro
- positive thymic T cell selection Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: T-cell surface glycoprotein CD3 delta chainAlternative name(s): T-cell receptor T3 delta chain CD_antigen: CD3d |
Gene namesi | Name:CD3D |
Organismi | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
Taxonomic identifieri | 9541 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- alpha-beta T cell receptor complex Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 105 | ExtracellularSequence analysisAdd BLAST | 84 | |
Transmembranei | 106 – 126 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 127 – 171 | CytoplasmicSequence analysisAdd BLAST | 45 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | By similarityAdd BLAST | 21 | |
ChainiPRO_0000016488 | 22 – 171 | T-cell surface glycoprotein CD3 delta chainAdd BLAST | 150 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 37 ↔ 73 | By similarity | ||
Glycosylationi | 38 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 54 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 74 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 149 | PhosphotyrosinePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 160 | PhosphotyrosinePROSITE-ProRule annotationBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinExpressioni
Tissue specificityi
Interactioni
Subunit structurei
The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.
Interacts with coreceptors CD4 and CD8.
By similarityGO - Molecular functioni
- identical protein binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
Protein-protein interaction databases
STRINGi | 9541.XP_005579855.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 138 – 166 | ITAMPROSITE-ProRule annotationAdd BLAST | 29 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S4XC, Eukaryota |
GeneTreei | ENSGT00940000153312 |
OMAi | YQPLRDH |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015484, CD3_esu/gsu/dsu IPR015485, CD3D IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR032052, Ig_4 IPR003110, Phos_immunorcpt_sig_ITAM |
PANTHERi | PTHR10570, PTHR10570, 1 hit PTHR10570:SF5, PTHR10570:SF5, 1 hit |
Pfami | View protein in Pfam PF16680, Ig_4, 1 hit PF02189, ITAM, 1 hit |
SMARTi | View protein in SMART SM00077, ITAM, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS51055, ITAM_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MEHSTFLSGL VLATLLSQVS PFKIPVEELE DRVFVKCNTS VTWVEGTVGT
60 70 80 90 100
LLTNNTRLDL GKRILDPRGI YRCNGTDIYK DKESAVQVHY RMCQNCVELD
110 120 130 140 150
PATLAGIIVT DVIATLLLAL GVFCFAGHET GRLSGAADTQ ALLRNDQVYQ
160 170
PLRDRDDAQY SRLGGNWARN K
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2K5VUZ5 | A0A2K5VUZ5_MACFA | T-cell receptor T3 delta chain | 127 | Annotation score: | |||
A0A2K5VV29 | A0A2K5VV29_MACFA | Uncharacterized protein | 98 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB073991 mRNA Translation: BAB71847.1 |
RefSeqi | NP_001274617.1, NM_001287688.1 |
Genome annotation databases
Ensembli | ENSMFAT00000002799; ENSMFAP00000028609; ENSMFAG00000045644 |
GeneIDi | 102133701 |
KEGGi | mcf:102133701 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB073991 mRNA Translation: BAB71847.1 |
RefSeqi | NP_001274617.1, NM_001287688.1 |
3D structure databases
SMRi | Q95LI8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9541.XP_005579855.1 |
Genome annotation databases
Ensembli | ENSMFAT00000002799; ENSMFAP00000028609; ENSMFAG00000045644 |
GeneIDi | 102133701 |
KEGGi | mcf:102133701 |
Organism-specific databases
CTDi | 915 |
Phylogenomic databases
eggNOGi | ENOG502S4XC, Eukaryota |
GeneTreei | ENSGT00940000153312 |
OMAi | YQPLRDH |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015484, CD3_esu/gsu/dsu IPR015485, CD3D IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR032052, Ig_4 IPR003110, Phos_immunorcpt_sig_ITAM |
PANTHERi | PTHR10570, PTHR10570, 1 hit PTHR10570:SF5, PTHR10570:SF5, 1 hit |
Pfami | View protein in Pfam PF16680, Ig_4, 1 hit PF02189, ITAM, 1 hit |
SMARTi | View protein in SMART SM00077, ITAM, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS51055, ITAM_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD3D_MACFA | |
Accessioni | Q95LI8Primary (citable) accession number: Q95LI8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 23, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |