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UniProtKB - Q95LI3 (ZFY_BOVIN)

Entry version 104 (02 Dec 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Zinc finger Y-chromosomal protein

Gene

ZFY

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri421 – 443C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 538C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri544 – 566C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 595C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri601 – 623C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri629 – 652C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri658 – 680C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri686 – 709C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri715 – 737C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri743 – 766C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri772 – 795C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger Y-chromosomal protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFY
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002505101 – 801Zinc finger Y-chromosomal proteinAdd BLAST801

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei269PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q95LI3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q95LI3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri421 – 443C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 538C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri544 – 566C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 595C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri601 – 623C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri629 – 652C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri658 – 680C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri686 – 709C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri715 – 737C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri743 – 766C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri772 – 795C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q95LI3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006794, Transcrp_activ_Zfx/Zfy-dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 6 hits
PF04704, Zfx_Zfy_act, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q95LI3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEDEFELQP QEPNSCFDGI GTDATHMDGD QIVVEVQETV FVSDVVDSDI 
        60         70         80         90        100
TVHNFVPDDP DSVVIQDVIE NVVIEDVQCS DILEEADVSE NVIIPEQMLS 
       110        120        130        140        150
SDVTEEVSLA HCTVPDDVLA SDITSASMSM PEHVLTSESV HVSDVGHVEH 
       160        170        180        190        200
IVHGSVVEAE IVTDPLTADV VSEEVLVADC ASEAVIDANG IPVDQQDDDK 
       210        220        230        240        250
GNCEDYLMIS LDDDGKMEHD CSSGMTMDAE SEIDPCKVDG TCPEVIKVYI 
       260        270        280        290        300
FKADPGEDDL GGTVDIVESE PENDHGVELL DQNNSIRMPR EKMVYMTVND 
       310        320        330        340        350
SQQEDEDLNV AEIADEVYME VIVGEEDAAV AAAAATTVHE QEMDDSEIKT 
       360        370        380        390        400
FMPIAWAAAY GNNSDGIENR SGTASALLHI DESAGLGRLT KHKPKKRRRP 
       410        420        430        440        450
DSRQYQTAII IGPDGHPLTV YPCMICGKKF KSRGFLKRHM KNHPEHLTKK 
       460        470        480        490        500
KYRCTDCDYT TNKKISLHNH LESHKLTSKS EKAIECDDCG KHFSHAGALF 
       510        520        530        540        550
THKMVHKEKG ASKMHKCKFC EYETAEQGLL NRHLLAVHSK NFPHICVECG 
       560        570        580        590        600
KGFRHPSELK KHMRIHTGEK PYQCQYCEYR SADSSNLKTH VKTKHSKEMS 
       610        620        630        640        650
FKCDICLLTF SDTKEVQQHA LIHQESKTHQ CVHCDHKSSN SSDLKRHIIS 
       660        670        680        690        700
VHTKDYPHKC DMCDKGFHRP SELKKHVAAH KGKKMHQCRH CDFKIADPFV 
       710        720        730        740        750
LSRHILSVHT KDLPFRCKRC KKGFRQQNEL KKHMKTHSGR KVYQCEYCEY 
       760        770        780        790        800
STTDASGFKR HVISIHTKDY PHRCEYCKKG FRRPSEKNQH ITRHHKEVGL 

P
Length:801
Mass (Da):90,344
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E34555E4653BE96
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF032867 mRNA Translation: AAL18261.1

NCBI Reference Sequences

More...RefSeqi		NP_803457.1, NM_177491.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		280962

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032867 mRNA Translation: AAL18261.1
RefSeqiNP_803457.1, NM_177491.1

3D structure databases

SMRiQ95LI3
ModBaseiSearch...

Proteomic databases

PRIDEiQ95LI3

Genome annotation databases

GeneIDi280962

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7544

Phylogenomic databases

InParanoidiQ95LI3

Family and domain databases

InterProiView protein in InterPro
IPR006794, Transcrp_activ_Zfx/Zfy-dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 6 hits
PF04704, Zfx_Zfy_act, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 13 hits
SUPFAMiSSF57667, SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFY_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q95LI3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 1, 2001
Last modified: December 2, 2020
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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