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Protein

Atypical chemokine receptor 1

Gene

ACKR1

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Atypical chemokine receptor 1
Alternative name(s):
Duffy antigen/chemokine receptor
CD_antigen: CD234
Gene namesi
Name:ACKR1
Synonyms:DARC, FY
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63ExtracellularSequence analysisAdd BLAST63
Transmembranei64 – 84Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini85 – 95CytoplasmicSequence analysisAdd BLAST11
Transmembranei96 – 116Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini117 – 129ExtracellularSequence analysisAdd BLAST13
Transmembranei130 – 153Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini154 – 166CytoplasmicSequence analysisAdd BLAST13
Transmembranei167 – 187Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini188 – 207ExtracellularSequence analysisAdd BLAST20
Transmembranei208 – 228Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini229 – 244CytoplasmicSequence analysisAdd BLAST16
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 287ExtracellularSequence analysisAdd BLAST22
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 336CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001525841 – 336Atypical chemokine receptor 1Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi51 ↔ 276By similarity
Disulfide bondi129 ↔ 195By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

BgeeiENSGGOG00000005139

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000005032

Structurei

3D structure databases

ProteinModelPortaliQ95LF9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000006372
HOVERGENiHBG051419
InParanoidiQ95LF9
KOiK06574
OMAiHCVATPL
OrthoDBiEOG091G0G1Y

Family and domain databases

CDDicd15010 7tmA_ACKR1_DARC, 1 hit
InterProiView protein in InterPro
IPR005384 Duffy_chemokine_rcpt
PANTHERiPTHR14181 PTHR14181, 1 hit
PRINTSiPR01559 DUFFYANTIGEN

Sequencei

Sequence statusi: Complete.

Q95LF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNCLHTAEL SPSTENSSQL DFEDAWNSSY DVNYSFPDVD YDANLEAAAP
60 70 80 90 100
CHSCNLLDDS ALPFFILTSV LGILASSTVL FILFRPLFRW QLCPGWPVLA
110 120 130 140 150
QLAVGSALFS IVVPILAPGL GSTHSSALCS LGYCVWYGSA FAQALLLGCH
160 170 180 190 200
ASLGHRLGAG QVPGLTLGLT VGIWGVAALL TLPVTLASGA SGGLCTPIHS
210 220 230 240 250
TELKALQATH TVACLAIFVL LPLGLFGAKG LKKALGMGPG PWMNILWAWF
260 270 280 290 300
IFWWPHGVVL GLDFLVRSKL LLLSTCLAQQ ALDLLLNLAE ALAILHCVAT
310 320 330
PLILALFYHQ ATRTLLPSLP LPEGWSSHLD TLGSKS
Length:336
Mass (Da):35,671
Last modified:December 1, 2001 - v1
Checksum:i81CF8DB8E0C185BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311914 Genomic DNA Translation: AAL09449.1
RefSeqiXP_004027105.1, XM_004027056.2

Genome annotation databases

EnsembliENSGGOT00000005162; ENSGGOP00000005032; ENSGGOG00000005139
GeneIDi101153049
KEGGiggo:101153049

Similar proteinsi

Entry informationi

Entry nameiACKR1_GORGO
AccessioniPrimary (citable) accession number: Q95LF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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