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UniProtKB - Q95LA2 (FMO1_CANLF)
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 1
Gene
FMO1
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.
Catalytic activityi
- EC:1.14.13.8
Cofactori
FADBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 32 | FADBy similarity | 1 | |
Sitei | 208 | Important for substrate bindingBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 9 – 13 | FADBy similarity | 5 | |
Nucleotide bindingi | 40 – 41 | FADBy similarity | 2 | |
Nucleotide bindingi | 60 – 61 | NADPBy similarity | 2 | |
Nucleotide bindingi | 61 – 62 | FADBy similarity | 2 | |
Nucleotide bindingi | 195 – 198 | NADPBy similarity | 4 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: InterPro
- monooxygenase activity Source: GO_Central
- N,N-dimethylaniline monooxygenase activity Source: UniProtKB-EC
- NADP binding Source: InterPro
GO - Biological processi
- NADPH oxidation Source: Ensembl
- organic acid metabolic process Source: Ensembl
- toxin metabolic process Source: Ensembl
- xenobiotic metabolic process Source: Ensembl
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | FAD, Flavoprotein, NADP |
Enzyme and pathway databases
Reactomei | R-CFA-217271, FMO oxidises nucleophiles |
Names & Taxonomyi
Protein namesi | Recommended name: Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC:1.14.13.8)Alternative name(s): Dimethylaniline oxidase 1 Hepatic flavin-containing monooxygenase 1 Short name: FMO 1 |
Gene namesi | Name:FMO1 |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:40916, FMO1 |
Subcellular locationi
Endoplasmic reticulum
- Microsome membrane 1 Publication; Single-pass membrane protein Sequence analysis
- Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 511 – 531 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000147637 | 2 – 532 | Dimethylaniline monooxygenase [N-oxide-forming] 1Add BLAST | 531 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | Q95LA2 |
Expressioni
Tissue specificityi
Liver.1 Publication
Gene expression databases
Bgeei | ENSCAFG00000014982, Expressed in brain and 23 other tissues |
Family & Domainsi
Sequence similaritiesi
Belongs to the FMO family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1399, Eukaryota |
GeneTreei | ENSGT00940000160945 |
HOGENOMi | CLU_006909_8_2_1 |
InParanoidi | Q95LA2 |
OMAi | VMIKEVN |
OrthoDBi | 405736at2759 |
TreeFami | TF105285 |
Family and domain databases
Gene3Di | 3.50.50.60, 4 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR000960, Flavin_mOase IPR020946, Flavin_mOase-like IPR002253, Flavin_mOase_1 |
Pfami | View protein in Pfam PF00743, FMO-like, 1 hit |
PIRSFi | PIRSF000332, FMO, 1 hit |
PRINTSi | PR00370, FMOXYGENASE PR01121, FMOXYGENASE1 |
SUPFAMi | SSF51905, SSF51905, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q95LA2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSDDLGGL WRFTEHVEEG
60 70 80 90 100
RASLYKSVVS NSCKEMSCYS DFPFPEDYPN YVPNSQFLEY LKMYANRFSL
110 120 130 140 150
LKCIRFKTKV CKVTKCPDFT VTGQWEVVTQ HEGKQESAIF DAVMVCTGFL
160 170 180 190 200
TNPHLPLDCF PGINTFKGQY FHSRQYKHPD IFKDKRVLVI GMGNSGTDIA
210 220 230 240 250
VETSRLAKKV FLSTTGGAWV MSRVFDSGYP WDMVFMTRFQ NMFRNSLPTP
260 270 280 290 300
IVTWLMARKM NSWFNHANYG LVPEDRTQLR EPVLNDELPG CIITGKVLIK
310 320 330 340 350
PSIKEVKENS VVFNNTPKEE PIDIIVFATG YTFAFPFLDE TVVKVENGQA
360 370 380 390 400
SLYKYIFPVH LPKPTLAVIG LIKPLGSMIP TGETQARWAV RVLKGINKLP
410 420 430 440 450
PQSAMTEEVN ARKENKPSGF GLCYCKALQS DYITYIDELL TNINAKPNLF
460 470 480 490 500
SLLLTDPRLA LTIFFGPCTP YQFRLTGPGK WKGARNAILT QWDRTFKVTK
510 520 530
TRIVQESPTP FASLLKLLSL LALLMAIFLI FL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A8I3MKC8 | A0A8I3MKC8_CANLF | Dimethylaniline monooxygenase [N-ox... | FMO1 | 127 | Annotation score: | ||
A0A8I3MPB1 | A0A8I3MPB1_CANLF | Dimethylaniline monooxygenase [N-ox... | FMO1 | 469 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF384053 mRNA Translation: AAK97433.1 |
RefSeqi | NP_001003061.1, NM_001003061.1 XP_005622281.1, XM_005622224.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF384053 mRNA Translation: AAK97433.1 |
RefSeqi | NP_001003061.1, NM_001003061.1 XP_005622281.1, XM_005622224.2 |
3D structure databases
AlphaFoldDBi | Q95LA2 |
SMRi | Q95LA2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9615.ENSCAFP00000022051 |
Proteomic databases
PaxDbi | Q95LA2 |
Genome annotation databases
Organism-specific databases
CTDi | 2326 |
VGNCi | VGNC:40916, FMO1 |
Phylogenomic databases
eggNOGi | KOG1399, Eukaryota |
GeneTreei | ENSGT00940000160945 |
HOGENOMi | CLU_006909_8_2_1 |
InParanoidi | Q95LA2 |
OMAi | VMIKEVN |
OrthoDBi | 405736at2759 |
TreeFami | TF105285 |
Enzyme and pathway databases
Reactomei | R-CFA-217271, FMO oxidises nucleophiles |
Gene expression databases
Bgeei | ENSCAFG00000014982, Expressed in brain and 23 other tissues |
Family and domain databases
Gene3Di | 3.50.50.60, 4 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR000960, Flavin_mOase IPR020946, Flavin_mOase-like IPR002253, Flavin_mOase_1 |
Pfami | View protein in Pfam PF00743, FMO-like, 1 hit |
PIRSFi | PIRSF000332, FMO, 1 hit |
PRINTSi | PR00370, FMOXYGENASE PR01121, FMOXYGENASE1 |
SUPFAMi | SSF51905, SSF51905, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | FMO1_CANLF | |
Accessioni | Q95LA2Primary (citable) accession number: Q95LA2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 129 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families