UniProtKB - Q95L97 (S20A2_FELCA)
Sodium-dependent phosphate transporter 2
SLC20A2
Functioni
Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not significantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage calcification and vascular calcification (By similarity).
Functions as a retroviral receptor for feline leukemia virus subgroup B (FeLV-B).
By similarity1 PublicationGO - Molecular functioni
- inorganic phosphate transmembrane transporter activity Source: InterPro
- symporter activity Source: UniProtKB-KW
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- phosphate ion transport Source: UniProtKB-KW
- sodium ion transport Source: UniProtKB-KW
Keywordsi
Molecular function | Host cell receptor for virus entry, Receptor |
Biological process | Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium-dependent phosphate transporter 2Alternative name(s): Phosphate transporter 2 Short name: FePit2 Short name: PiT-2 Solute carrier family 20 member 2 |
Gene namesi | Name:SLC20A2 Synonyms:PIT2 |
Organismi | Felis catus (Cat) (Felis silvestris catus) |
Taxonomic identifieri | 9685 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 5 | ExtracellularSequence analysis | 5 | |
Transmembranei | 6 – 26 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 27 – 46 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 47 – 67 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 68 – 86 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 109 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 110 – 130 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 131 – 142 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 143 – 163 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 164 – 190 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 191 – 211 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 212 – 213 | ExtracellularSequence analysis | 2 | |
Transmembranei | 214 – 234 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 235 – 483 | CytoplasmicSequence analysisAdd BLAST | 249 | |
Transmembranei | 484 – 504 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 505 – 531 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 532 – 552 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 553 – 572 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 573 – 587 | HelicalSequence analysisAdd BLAST | 15 | |
Topological domaini | 588 – 594 | ExtracellularSequence analysis | 7 | |
Transmembranei | 595 – 610 | HelicalSequence analysisAdd BLAST | 16 | |
Topological domaini | 611 – 622 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 623 – 643 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 644 – 653 | ExtracellularSequence analysis | 10 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000341267 | 1 – 653 | Sodium-dependent phosphate transporter 2Add BLAST | 653 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 81 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 253 | PhosphoserineBy similarity | 1 | |
Modified residuei | 256 | PhosphoserineBy similarity | 1 | |
Modified residuei | 259 | PhosphoserineBy similarity | 1 | |
Modified residuei | 268 | PhosphoserineBy similarity | 1 | |
Modified residuei | 316 | PhosphoserineBy similarity | 1 | |
Modified residuei | 385 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinInteractioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 9685.ENSFCAP00000009354 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 275 – 311 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 459 – 478 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 283 – 305 | Polar residuesSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2493, Eukaryota |
InParanoidi | Q95L97 |
TreeFami | TF314426 |
Family and domain databases
InterProi | View protein in InterPro IPR001204, Phos_transporter |
PANTHERi | PTHR11101, PTHR11101, 1 hit |
Pfami | View protein in Pfam PF01384, PHO4, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAIDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL
60 70 80 90 100
ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV
110 120 130 140 150
WQLIASFLRL PISGTHCIVG STIGFSLVAI GTQGVQWMEL VKIVASWFIS
160 170 180 190 200
PLLSGFMSGV LFILIRIFIL KKEDPVPNGL RALPVFYAAT IAINVFSIMY
210 220 230 240 250
TGAPVLGLVL PIWAIALISF GVALLFALFV WLFVCPWMRR KIAGKLQKEA
260 270 280 290 300
ALSRVSDESL SKIQEVESPV FKELPGAKAN DDSTVPLTGS AGEPSGTSEG
310 320 330 340 350
TSVGNHPRAS YGRALSMTHG SAKSPVSNGT FGFDGHTRSD GHVYHTVHKD
360 370 380 390 400
SGLYKDLLHR IHSDRGPEER PAQENNYRFL RRNNSYTCYT AAICGMPVHS
410 420 430 440 450
TFKAADSSSA PEDSEKLVGD AVSYSKKRLR YDSYSSYCNA VAEAEIEADE
460 470 480 490 500
GGVEMKLASE LTDPDQPRDD PAEEEKEEKD TAEVHLLFHF LQVLTACFGS
510 520 530 540 550
FAHGGNDVSN AIGPLVALWL IYEQGAVLQE AVTPVWLLFY GGVGICTGLW
560 570 580 590 600
VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNVG LPVSTTHCKV
610 620 630 640 650
GSVVAVGWIR SRKAVDWRLF RNIFVAWFVT VPVAGLFSAA IMALLMYGIL
PYV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF394194 mRNA Translation: AAK73822.1 |
RefSeqi | NP_001009839.1, NM_001009839.1 |
Genome annotation databases
GeneIDi | 493788 |
KEGGi | fca:493788 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF394194 mRNA Translation: AAK73822.1 |
RefSeqi | NP_001009839.1, NM_001009839.1 |
3D structure databases
SMRi | Q95L97 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9685.ENSFCAP00000009354 |
Genome annotation databases
GeneIDi | 493788 |
KEGGi | fca:493788 |
Organism-specific databases
CTDi | 6575 |
Phylogenomic databases
eggNOGi | KOG2493, Eukaryota |
InParanoidi | Q95L97 |
TreeFami | TF314426 |
Family and domain databases
InterProi | View protein in InterPro IPR001204, Phos_transporter |
PANTHERi | PTHR11101, PTHR11101, 1 hit |
Pfami | View protein in Pfam PF01384, PHO4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S20A2_FELCA | |
Accessioni | Q95L97Primary (citable) accession number: Q95L97 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families