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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Gene

NDUFA13

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.By similarity

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processApoptosis, Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport
R-BTA-6799198 Complex I biogenesis

Protein family/group databases

TCDBi3.D.1.6.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Alternative name(s):
Cell death regulatory protein GRIM-19
Complex I-B16.6
Short name:
CI-B16.6
Gene associated with retinoic-interferon-induced mortality 19 protein
Short name:
GRIM-19
NADH-ubiquinone oxidoreductase B16.6 subunit
Gene namesi
Name:NDUFA13
Synonyms:GRIM19
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:31946 NDUFA13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 51HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001188032 – 144NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13Add BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ95KV7
PRIDEiQ95KV7

PTM databases

iPTMnetiQ95KV7

Expressioni

Gene expression databases

BgeeiENSBTAG00000007812

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits (PubMed:18721790). Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4.By similarity1 Publication

Protein-protein interaction databases

CORUMiQ95KV7
DIPiDIP-38831N
IntActiQ95KV7, 2 interactors
STRINGi9913.ENSBTAP00000010276

Structurei

3D structure databases

SMRiQ95KV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA13 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3300 Eukaryota
ENOG4111KIB LUCA
GeneTreeiENSGT00390000000719
HOGENOMiHOG000195836
HOVERGENiHBG019074
InParanoidiQ95KV7
KOiK11353
OMAiSGYSMFG
OrthoDBiEOG091G0MHM
TreeFamiTF315182

Family and domain databases

InterProiView protein in InterPro
IPR009346 GRIM-19
PANTHERiPTHR12966 PTHR12966, 1 hit
PfamiView protein in Pfam
PF06212 GRIM-19, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95KV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASKVKQDM PPVGGYGPID YKRNLPRRGL SGYSMFAVGI GALLFGYWSM
60 70 80 90 100
MKWNRERRRL QIEDFEARIA LMPLLQAEKD RRVLQMLREN LEEEATVMKD
110 120 130 140
VPGWKVGESV FHTTRWVTPM MGELYGLRAS EEVLSATYGF IWYT
Length:144
Mass (Da):16,673
Last modified:January 23, 2007 - v3
Checksum:i9AA885FFA4748347
GO

Mass spectrometryi

Molecular mass is 16585 Da from positions 2 - 144. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ316011 mRNA Translation: CAC87049.1
BC102406 mRNA Translation: AAI02407.1
RefSeqiNP_788845.1, NM_176672.2
UniGeneiBt.49187

Genome annotation databases

EnsembliENSBTAT00000010276; ENSBTAP00000010276; ENSBTAG00000007812
GeneIDi338084
KEGGibta:338084

Similar proteinsi

Entry informationi

Entry nameiNDUAD_BOVIN
AccessioniPrimary (citable) accession number: Q95KV7
Secondary accession number(s): Q3T0G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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