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Entry version 176 (17 Jun 2020)
Sequence version 1 (01 Feb 1997)
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Protein

Major histocompatibility complex class I-related gene protein

Gene

MR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells (PubMed:23051753, PubMed:26795251, PubMed:12794138, PubMed:19416870, PubMed:22692454, PubMed:23846752). In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1-2 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (PubMed:26795251, PubMed:24695216, PubMed:20581831). Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively (PubMed:24695216). May present microbial antigens to various TRAV1-2-negative MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin (PubMed:27527800, PubMed:31113973). Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (PubMed:24695216, PubMed:27527800, PubMed:23846752). During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity). Acts as an immune sensor of cancer cell metabolome (PubMed:31959982). May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR consisting of TRAV38.2-DV8*TRAJ31 alpha chain paired with a TRBV25.1*TRBJ2.3 beta chain on a non-MAIT CD8-positive T cell clone (MC.7.G5), triggering T cell-mediated killing of a wide range of cancer cell types (PubMed:31959982).By similarity11 Publications

Caution

Reported to be associated with components of the peptide-loading complex, TAPBP, CALR, CANX and PDIA3 (PubMed:23457030, PubMed:12794138). This association in primary cells and its functional relevance is disputable, given that antigen presentation and MAIT cell activation is shown to be TAP1-TAP2 and proteasome-independent.1 Publication2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Usually inhibited by pterin-based metabolites such as 6-formylpterin (6-FP, a product of folic acid photodegradation). 6-FP competitively inhibits MAIT cell activation by 5-OP-RU (PubMed:28166217). Modulated by commonly prescribed anti-inflammatory drug metabolites. Inhibited by salicilates such as 3-formylsalicylic and 5-formylsalicylic acids. Activated by diclofenac and/or its hydroxy metabolites (PubMed:28166217).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei31Pathogen-derived metabolite antigen (5-(2-oxoethylideneamino)-6-D-ribitylaminouracil or 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil)2 Publications1
Binding sitei46Pathogen-derived metabolite antigen (5-(2-oxoethylideneamino)-6-D-ribitylaminouracil or 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil); drug metabolite (diclofenac or 5-hydroxydiclofenac)4 Publications1
Binding sitei65Pathogen-derived metabolite antigen (5-(2-oxoethylideneamino)-6-D-ribitylaminouracil or 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil) (covalent); drug metabolite (2,4-diamino-6-formylpteridine) (covalent)5 Publications1
Binding sitei80Pathogen-derived metabolite antigen (5-(2-oxopropylideneamino)-6-D-ribitylaminouracil)1 Publication1
Binding sitei174Pathogen-derived metabolite antigen (5-(2-oxoethylideneamino)-6-D-ribitylaminouracil or 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil)2 Publications1
Binding sitei175Pathogen-derived metabolite antigen (5-(2-oxoethylideneamino)-6-D-ribitylaminouracil or 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil)2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Innate immunity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Major histocompatibility complex class I-related gene protein
Short name:
MHC class I-related gene protein
Alternative name(s):
Class I histocompatibility antigen-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000153029.14

Human Gene Nomenclature Database

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HGNCi
HGNC:4975 MR1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600764 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q95460

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 302ExtracellularSequence analysisAdd BLAST280
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 341CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, MHC I, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi65K → A: Associates with B2M and translocates to plasma membrane in the absence of 6-FP. Impairs recognition by pan-cancer TCR, MC.7.G5. 2 Publications1
Mutagenesisi65K → R: Fails to refold in the presence of 6-FP. Impairs the association with B2M and translocation to the plasma membrane. 2 Publications1
Mutagenesisi169Q → L: Able to activate mouse MAIT cells (xeno-reactivity). 1 Publication1
Mutagenesisi283C → G: No effect on cell surface expression. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3140

MalaCards human disease database

More...
MalaCardsi
MR1

Open Targets

More...
OpenTargetsi
ENSG00000153029

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29309

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q95460 Tbio

Chemistry databases

Drug and drug target database

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DrugBanki
DB00098 Antithymocyte immunoglobulin (rabbit)

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751679

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000034444123 – 341Major histocompatibility complex class I-related gene proteinAdd BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi107N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi120 ↔ 183PROSITE-ProRule annotation3 Publications
Disulfide bondi222 ↔ 278PROSITE-ProRule annotation3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q95460

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q95460

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q95460

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q95460

PeptideAtlas

More...
PeptideAtlasi
Q95460

PRoteomics IDEntifications database

More...
PRIDEi
Q95460

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75731 [Q95460-1]
75732 [Q95460-2]
75733 [Q95460-3]
75734 [Q95460-4]
75735 [Q95460-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q95460

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q95460

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous (PubMed:7624800, PubMed:9780177). Low expression is detected in peripheral blood B cells, T cells, monocytes and in bronchial epithelial cells (at protein level) (PubMed:27043408). Expressed in plasmablasts or plasma B cells in the lamina propria of ileum, appendix and colon (at protein level) (PubMed:19760593). Highly expressed on a subset of CD45-positive CD3-positive thymocytes (at protein level) (PubMed:22692454).5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000153029 Expressed in lymph node and 216 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q95460 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000153029 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer that consists of MR1, B2M and a metabolite antigen (PubMed:27043408, PubMed:23051753, PubMed:23846752, PubMed:24695216). Forms reversible covalent Schiff base complexes with the microbial metabolite, which serves as a molecular switch triggering complete folding, stable association with B2M and translocation of the ternary complex from endoplasmic reticulum to the plasma membrane (PubMed:27043408, PubMed:23051753, PubMed:23846752, PubMed:24695216). On antigen-presenting cells, the ternary complex interacts with TCR on CD8-positive T cells (PubMed:23846752, PubMed:24695216, PubMed:26795251). The molecular machinery involved in antigen processing remains unknown, but appears to be TAP1-TAP2 and proteasome-independent. Structurally, MR1-B2M heterodimer adopts a topology similar to classical MHC class I molecules, with alpha-1 and alpha-2 domains of MR1 forming the antigen-binding cleft composed of two alpha-helices resting on a floor of 7-stranded anti-parallel beta-pleated sheet (PubMed:23846752, PubMed:24695216, PubMed:26795251). The ribityl moiety of pyrimidine-based antigens is recognized by Tyr-95 residue in the CDR3 alpha loop of the invariant TRAV1-2 TCR (PubMed:23846752, PubMed:24695216, PubMed:26795251).

5 Publications

Homodimerizes and does not associate with B2M.

1 Publication1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
109385, 23 interactors

Database of interacting proteins

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DIPi
DIP-59986N

Protein interaction database and analysis system

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IntActi
Q95460, 16 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000477563

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q95460 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q95460

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini203 – 299Ig-like C1-typeAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni23 – 201Antigen-binding cleft1 PublicationAdd BLAST179
Regioni23 – 109Alpha-1Sequence analysisAdd BLAST87
Regioni110 – 201Alpha-2Sequence analysisAdd BLAST92
Regioni202 – 293Alpha-3Sequence analysisAdd BLAST92
Regioni294 – 302Connecting peptide9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-1 domain is a structural part of antigen-binding cleft.3 Publications
The alpha-2 domain is a structural part of antigen-binding cleft.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410II5V Eukaryota
ENOG4111K8F LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00990000203566

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_047501_0_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q95460

Identification of Orthologs from Complete Genome Data

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OMAi
CHVEHCG

Database of Orthologous Groups

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OrthoDBi
912212at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q95460

TreeFam database of animal gene trees

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TreeFami
TF336617

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 1 hit
3.30.500.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2

Pfam protein domain database

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Pfami
View protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01638 MHCCLASSI

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00407 IGc1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q95460-1) [UniParc]FASTAAdd to basket
Also known as: MR1A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MGELMAFLLP LIIVLMVKHS DSRTHSLRYF RLGVSDPIHG VPEFISVGYV
60 70 80 90 100
DSHPITTYDS VTRQKEPRAP WMAENLAPDH WERYTQLLRG WQQMFKVELK
110 120 130 140 150
RLQRHYNHSG SHTYQRMIGC ELLEDGSTTG FLQYAYDGQD FLIFNKDTLS
160 170 180 190 200
WLAVDNVAHT IKQAWEANQH ELLYQKNWLE EECIAWLKRF LEYGKDTLQR
210 220 230 240 250
TEPPLVRVNR KETFPGVTAL FCKAHGFYPP EIYMTWMKNG EEIVQEIDYG
260 270 280 290 300
DILPSGDGTY QAWASIELDP QSSNLYSCHV EHCGVHMVLQ VPQESETIPL
310 320 330 340
VMKAVSGSIV LVIVLAGVGV LVWRRRPREQ NGAIYLPTPD R
Length:341
Mass (Da):39,366
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2990C1F3F0A1CAD9
GO
Isoform 2 (identifier: Q95460-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-154: Missing.

Show »
Length:296
Mass (Da):34,278
Checksum:i05ABC9CD4189F639
GO
Isoform 3 (identifier: Q95460-3) [UniParc]FASTAAdd to basket
Also known as: MR1B, MR1D

The sequence of this isoform differs from the canonical sequence as follows:
     203-294: Missing.

Show »
Length:249
Mass (Da):28,973
Checksum:iDED2E979686D6A8A
GO
Isoform 4 (identifier: Q95460-4) [UniParc]FASTAAdd to basket
Also known as: MR1C

The sequence of this isoform differs from the canonical sequence as follows:
     202-220: EPPLVRVNRKETFPGVTAL → GKEKEKASFPHCLNNCFYT
     221-341: Missing.

Show »
Length:220
Mass (Da):25,933
Checksum:i529688A56159C475
GO
Isoform 5 (identifier: Q95460-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     202-328: Missing.

Show »
Length:214
Mass (Da):25,190
Checksum:iB84A09E70B280E74
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD01443 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti117M → V in BAF83063 (PubMed:14702039).Curated1
Sequence conflicti200R → G in BAD96630 (Ref. 4) Curated1
Sequence conflicti315L → P in BAD96630 (Ref. 4) Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Several individuals from different ethnic background were analyzed for polymorphism. MR1 was identical in all individuals analyzed, except one. MR1 is not polymorphic.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04560839H → R1 PublicationCorresponds to variant dbSNP:rs2236410EnsemblClinVar.1
Natural variantiVAR_04560963R → Q. Corresponds to variant dbSNP:rs3897433Ensembl.1
Natural variantiVAR_04561077A → V. Corresponds to variant dbSNP:rs3897434Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034755110 – 154Missing in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_043479202 – 328Missing in isoform 5. 1 PublicationAdd BLAST127
Alternative sequenceiVSP_034756202 – 220EPPLV…GVTAL → GKEKEKASFPHCLNNCFYT in isoform 4. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_034757203 – 294Missing in isoform 3. 2 PublicationsAdd BLAST92
Alternative sequenceiVSP_034758221 – 341Missing in isoform 4. 1 PublicationAdd BLAST121

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U22963 mRNA Translation: AAC50174.1
AJ249778 mRNA Translation: CAB77667.1
AK290374 mRNA Translation: BAF83063.1
AK304645 mRNA Translation: BAG65423.1
AK222910 mRNA Translation: BAD96630.1
AL356267 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91097.1
CH471067 Genomic DNA Translation: EAW91098.1
CH471067 Genomic DNA Translation: EAW91095.1
BC012485 mRNA Translation: AAH12485.1
AF010446 mRNA Translation: AAD01442.1
AF010447 mRNA Translation: AAD01443.1 Different initiation.
AF031469 mRNA Translation: AAD01933.1
AF039526 Genomic DNA Translation: AAD02172.1
AH006983 Genomic DNA Translation: AAC72900.1
AF223407 Genomic DNA Translation: AAF40170.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1342.1 [Q95460-1]
CCDS53440.1 [Q95460-3]
CCDS53441.1 [Q95460-5]
CCDS53442.1 [Q95460-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A57136

NCBI Reference Sequences

More...
RefSeqi
NP_001181928.1, NM_001194999.1 [Q95460-2]
NP_001181929.1, NM_001195000.1 [Q95460-3]
NP_001181964.1, NM_001195035.1 [Q95460-5]
NP_001522.1, NM_001531.2 [Q95460-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282990; ENSP00000282990; ENSG00000153029 [Q95460-3]
ENST00000367579; ENSP00000356551; ENSG00000153029 [Q95460-2]
ENST00000367580; ENSP00000356552; ENSG00000153029 [Q95460-1]
ENST00000434571; ENSP00000388504; ENSG00000153029 [Q95460-5]
ENST00000614012; ENSP00000477563; ENSG00000153029 [Q95460-1]
ENST00000617803; ENSP00000478976; ENSG00000153029 [Q95460-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3140

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3140

UCSC genome browser

More...
UCSCi
uc001goq.2 human [Q95460-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22963 mRNA Translation: AAC50174.1
AJ249778 mRNA Translation: CAB77667.1
AK290374 mRNA Translation: BAF83063.1
AK304645 mRNA Translation: BAG65423.1
AK222910 mRNA Translation: BAD96630.1
AL356267 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91097.1
CH471067 Genomic DNA Translation: EAW91098.1
CH471067 Genomic DNA Translation: EAW91095.1
BC012485 mRNA Translation: AAH12485.1
AF010446 mRNA Translation: AAD01442.1
AF010447 mRNA Translation: AAD01443.1 Different initiation.
AF031469 mRNA Translation: AAD01933.1
AF039526 Genomic DNA Translation: AAD02172.1
AH006983 Genomic DNA Translation: AAC72900.1
AF223407 Genomic DNA Translation: AAF40170.1
CCDSiCCDS1342.1 [Q95460-1]
CCDS53440.1 [Q95460-3]
CCDS53441.1 [Q95460-5]
CCDS53442.1 [Q95460-2]
PIRiA57136
RefSeqiNP_001181928.1, NM_001194999.1 [Q95460-2]
NP_001181929.1, NM_001195000.1 [Q95460-3]
NP_001181964.1, NM_001195035.1 [Q95460-5]
NP_001522.1, NM_001531.2 [Q95460-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GUPX-ray3.20A/C23-292[»]
4L4TX-ray2.00A/C23-292[»]
4L4VX-ray1.90A/C23-292[»]
4LCWX-ray2.40A/C23-292[»]
4NQCX-ray2.50A/C23-292[»]
4NQDX-ray2.20A/C23-292[»]
4NQEX-ray2.10A/C23-292[»]
4PJ5X-ray2.00A/C23-292[»]
4PJ7X-ray2.50A/C23-292[»]
4PJ8X-ray3.30A23-292[»]
4PJ9X-ray2.00A23-292[»]
4PJAX-ray2.68A/C23-292[»]
4PJBX-ray2.85A/C23-292[»]
4PJCX-ray2.50A/C23-292[»]
4PJDX-ray2.78A/C23-292[»]
4PJEX-ray1.95A/C23-292[»]
4PJFX-ray2.45A/C23-292[»]
4PJGX-ray2.40A/C23-292[»]
4PJHX-ray2.00A/C23-292[»]
4PJIX-ray2.50A/C23-292[»]
4PJXX-ray2.25A/C23-292[»]
5D5MX-ray2.20A/C23-292[»]
5D7IX-ray2.00A/C23-292[»]
5D7JX-ray1.97C/E23-292[»]
5D7LX-ray3.40A/C23-292[»]
5U16X-ray2.00A/C23-292[»]
5U17X-ray2.15A/C23-292[»]
5U1RX-ray2.70A/C23-292[»]
5U2VX-ray2.20A/C23-292[»]
5U6QX-ray1.90A/C23-292[»]
5U72X-ray2.50A/C23-292[»]
6MWRX-ray3.30A23-292[»]
6PUCX-ray1.85A/C23-292[»]
6PUDX-ray1.80A/C23-292[»]
6PUEX-ray1.90A/C23-292[»]
6PUFX-ray1.92A/C23-292[»]
6PUGX-ray1.80A/C23-292[»]
6PUHX-ray1.88A/C23-292[»]
6PUIX-ray1.96A/C23-292[»]
6PUJX-ray1.92A/C23-292[»]
6PUKX-ray2.08A/C23-292[»]
6PULX-ray1.84A/C23-292[»]
6PUMX-ray1.96A/C23-292[»]
SMRiQ95460
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109385, 23 interactors
DIPiDIP-59986N
IntActiQ95460, 16 interactors
STRINGi9606.ENSP00000477563

Chemistry databases

DrugBankiDB00098 Antithymocyte immunoglobulin (rabbit)

PTM databases

iPTMnetiQ95460
PhosphoSitePlusiQ95460

Polymorphism and mutation databases

BioMutaiMR1
DMDMi74751679

Proteomic databases

EPDiQ95460
jPOSTiQ95460
MassIVEiQ95460
PaxDbiQ95460
PeptideAtlasiQ95460
PRIDEiQ95460
ProteomicsDBi75731 [Q95460-1]
75732 [Q95460-2]
75733 [Q95460-3]
75734 [Q95460-4]
75735 [Q95460-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34431 171 antibodies

Genome annotation databases

EnsembliENST00000282990; ENSP00000282990; ENSG00000153029 [Q95460-3]
ENST00000367579; ENSP00000356551; ENSG00000153029 [Q95460-2]
ENST00000367580; ENSP00000356552; ENSG00000153029 [Q95460-1]
ENST00000434571; ENSP00000388504; ENSG00000153029 [Q95460-5]
ENST00000614012; ENSP00000477563; ENSG00000153029 [Q95460-1]
ENST00000617803; ENSP00000478976; ENSG00000153029 [Q95460-3]
GeneIDi3140
KEGGihsa:3140
UCSCiuc001goq.2 human [Q95460-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3140
DisGeNETi3140
EuPathDBiHostDB:ENSG00000153029.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MR1
HGNCiHGNC:4975 MR1
HPAiENSG00000153029 Low tissue specificity
MalaCardsiMR1
MIMi600764 gene
neXtProtiNX_Q95460
OpenTargetsiENSG00000153029
PharmGKBiPA29309

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
GeneTreeiENSGT00990000203566
HOGENOMiCLU_047501_0_1_1
InParanoidiQ95460
OMAiCHVEHCG
OrthoDBi912212at2759
PhylomeDBiQ95460
TreeFamiTF336617

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3140 3 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MR1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Major_histocompatibility_complex,_class_I-related

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3140
PharosiQ95460 Tbio

Protein Ontology

More...
PROi
PR:Q95460
RNActiQ95460 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000153029 Expressed in lymph node and 216 other tissues
GenevisibleiQ95460 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q95460
Secondary accession number(s): A8K2V9
, B4E3B1, O97985, O97986, Q53GM1, Q95HB8, Q9MY23, Q9NPL2, Q9TQB3, Q9TQB9, Q9TQK3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: February 1, 1997
Last modified: June 17, 2020
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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