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Protein

HLA class I histocompatibility antigen, B-38 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-38 alpha chain
Alternative name(s):
Bw-4
MHC class I antigen B*38
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932 HLA-B
MIMi142830 gene
neXtProtiNX_Q95365

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 362CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3106
MalaCardsiHLA-B

Polymorphism and mutation databases

DMDMi34305608

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001884225 – 362HLA class I histocompatibility antigen, B-38 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ95365
PeptideAtlasiQ95365
PRIDEiQ95365

PTM databases

GlyConnecti1336
SwissPalmiQ95365

Expressioni

Gene expression databases

CleanExiHS_HLA-B

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ95365
SMRiQ95365
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709
OrthoDBiEOG091G09OH

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 54 potential isoforms that are computationally mapped.Show allAlign All

Q95365-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI CKTNTQTYRE
110 120 130 140 150
NLRIALRYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHNQF AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAARVAEQL RTYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAASS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,416
Last modified:February 1, 1997 - v1
Checksum:i41F49A1A19DF21C7
GO

Computationally mapped potential isoform sequencesi

There are 54 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P018891B07_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P039891B27_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304601B08_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
Q048261B40_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304751B39_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304861B48_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
Q298361B67_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304641B15_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
Q316101B81_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
P304801B42_HUMAN
HLA class I histocompatibility anti...
HLA-B HLAB
362Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130 – 131DG → ER in AAA36222 (PubMed:2777338).Curated2
Sequence conflicti191 – 192WL → CV in AAA36222 (PubMed:2777338).Curated2

Polymorphismi

The following alleles of B-38 are known: B*38:01, B*38:02, B*38:03, B*38:04, B*38:05, B*38:06, B*38:07 and B*38:08. The sequence shown is that of B*38:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0563474M → T. Corresponds to variant dbSNP:rs1050458Ensembl.1
Natural variantiVAR_0563489V → L. Corresponds to variant dbSNP:rs1050462Ensembl.1
Natural variantiVAR_05634917L → V. Corresponds to variant dbSNP:rs1131165Ensembl.1
Natural variantiVAR_01641135S → A in allele B*38:05. Corresponds to variant dbSNP:rs1131170Ensembl.1
Natural variantiVAR_05635036V → M. Corresponds to variant dbSNP:rs1050486Ensembl.1
Natural variantiVAR_06140748S → A. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_06140848S → P. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_06140948S → T. Corresponds to variant dbSNP:rs713031Ensembl.1
Natural variantiVAR_05635165A → TCombined sourcesCorresponds to variant dbSNP:rs1050529Ensembl.1
Natural variantiVAR_01641269E → T in allele B*38:06 and allele B*38:07; requires 2 nucleotide substitutions. Combined sources1
Natural variantiVAR_01641382E → G in allele B*38:07. 1
Natural variantiVAR_05635287N → D. Corresponds to variant dbSNP:rs1050570Ensembl.1
Natural variantiVAR_01641487N → E in allele B*38:03 and allele B*38:04; requires 2 nucleotide substitutions. Combined sources1
Natural variantiVAR_05947887N → K. Corresponds to variant dbSNP:rs1065386Ensembl.1
Natural variantiVAR_01641591C → F in allele B*38:06 and allele B*38:07. 1
Natural variantiVAR_01641691C → S in allele B*38:03. 1
Natural variantiVAR_01641798Y → D in allele B*38:03. 1
Natural variantiVAR_016418101N → S in allele B*38:03. 1
Natural variantiVAR_016419104I → T in allele B*38:02, allele B*38:03, allele B*38:04 and allele B*38:08. 1
Natural variantiVAR_016420187T → M in allele B*38:08. 1
Natural variantiVAR_056353306V → I. Corresponds to variant dbSNP:rs1131500Ensembl.1
Natural variantiVAR_056354329A → T. Corresponds to variant dbSNP:rs1051488Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36591 mRNA Translation: AAA73509.1
U40498 mRNA Translation: AAD00010.1
L22028 mRNA Translation: AAA59618.1
AJ297317 Genomic DNA Translation: CAC29063.1
AH005604 Genomic DNA Translation: AAB82305.1
AJ308991, AJ308992 Genomic DNA Translation: CAC34965.1
AF081275 mRNA Translation: AAC32198.1
AF081276 Genomic DNA Translation: AAC32199.1
AH008211 Genomic DNA Translation: AAD56222.1
AH009484 Genomic DNA Translation: AAF78055.1
AH009277 Genomic DNA Translation: AAF67340.1
AH010893 Genomic DNA Translation: AAK69506.1
AH011066 Genomic DNA Translation: AAL04500.1
M29864 Genomic DNA Translation: AAA36222.1
PIRiA59028
I54463
UniGeneiHs.654404
Hs.726974
Hs.77961

Genome annotation databases

EnsembliENST00000425848; ENSP00000400842; ENSG00000223532
UCSCiuc011fcq.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36591 mRNA Translation: AAA73509.1
U40498 mRNA Translation: AAD00010.1
L22028 mRNA Translation: AAA59618.1
AJ297317 Genomic DNA Translation: CAC29063.1
AH005604 Genomic DNA Translation: AAB82305.1
AJ308991, AJ308992 Genomic DNA Translation: CAC34965.1
AF081275 mRNA Translation: AAC32198.1
AF081276 Genomic DNA Translation: AAC32199.1
AH008211 Genomic DNA Translation: AAD56222.1
AH009484 Genomic DNA Translation: AAF78055.1
AH009277 Genomic DNA Translation: AAF67340.1
AH010893 Genomic DNA Translation: AAK69506.1
AH011066 Genomic DNA Translation: AAL04500.1
M29864 Genomic DNA Translation: AAA36222.1
PIRiA59028
I54463
UniGeneiHs.654404
Hs.726974
Hs.77961

3D structure databases

ProteinModelPortaliQ95365
SMRiQ95365
ModBaseiSearch...
MobiDBiSearch...

PTM databases

GlyConnecti1336
SwissPalmiQ95365

Polymorphism and mutation databases

DMDMi34305608

Proteomic databases

MaxQBiQ95365
PeptideAtlasiQ95365
PRIDEiQ95365

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000425848; ENSP00000400842; ENSG00000223532
UCSCiuc011fcq.2 human

Organism-specific databases

DisGeNETi3106
GeneCardsiHLA-B
HGNCiHGNC:4932 HLA-B
MalaCardsiHLA-B
MIMi142830 gene
neXtProtiNX_Q95365
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709
OrthoDBiEOG091G09OH

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

ChiTaRSiHLA-B human
SOURCEiSearch...

Gene expression databases

CleanExiHS_HLA-B

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei1B38_HUMAN
AccessioniPrimary (citable) accession number: Q95365
Secondary accession number(s): O19779
, O77959, O78160, Q29935, Q29936, Q95IB8, Q95IH5, Q9BCM8, Q9MY92, Q9MYG1, Q9TPT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: February 1, 1997
Last modified: October 10, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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