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Protein

60S ribosomal protein L13a

Gene

RPL13A

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L13a
Gene namesi
Name:RPL13A
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000133771‹1 – ›13760S ribosomal protein L13aAdd BLAST›137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55CitrullineBy similarity1
Modified residuei73PhosphoserineBy similarity1
Modified residuei136CitrullineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-73 is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.By similarity
Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

PaxDbiQ95307
PeptideAtlasiQ95307
PRIDEiQ95307

Interactioni

Subunit structurei

Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000003433

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3204 Eukaryota
COG0102 LUCA
HOGENOMiHOG000225289
HOVERGENiHBG062176
InParanoidiQ95307

Family and domain databases

CDDicd00392 Ribosomal_L13, 1 hit
Gene3Di3.90.1180.10, 1 hit
HAMAPiMF_01366 Ribosomal_L13, 1 hit
InterProiView protein in InterPro
IPR005822 Ribosomal_L13
IPR023563 Ribosomal_L13_CS
IPR005755 Ribosomal_L13_euk/arc
IPR036899 Ribosomal_L13_sf
PANTHERiPTHR11545 PTHR11545, 1 hit
PTHR11545:SF3 PTHR11545:SF3, 1 hit
PfamiView protein in Pfam
PF00572 Ribosomal_L13, 1 hit
PIRSFiPIRSF002181 Ribosomal_L13, 1 hit
SUPFAMiSSF52161 SSF52161, 1 hit
TIGRFAMsiTIGR01077 L13_A_E, 1 hit
PROSITEiView protein in PROSITE
PS00783 RIBOSOMAL_L13, 1 hit

Sequencei

Sequence statusi: Fragment.

Q95307-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QVLVLDGRGH LLGRLAAIVA KQVLLGRKVV VVRCEGINIS GNFYRNKLKY
60 70 80 90 100
LAFLRKRMNT NPSRGPYHFR APSRIFWRTV RGMLPHKTKR GQAALDRLKV
110 120 130
FDGIPPPYDK KKRMVVPAAL KVVRLKLTGK FXYLGRL
Length:137
Mass (Da):15,674
Last modified:November 1, 1997 - v2
Checksum:iC5245A7696CD0217
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti16A → V in CAB03544 (Ref. 1) Curated1
Non-terminal residuei1371

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81152 mRNA Translation: CAB03544.1
Z84103 mRNA Translation: CAB06326.1
UniGeneiSsc.17024
Ssc.27927
Ssc.63662

Similar proteinsi

Entry informationi

Entry nameiRL13A_PIG
AccessioniPrimary (citable) accession number: Q95307
Secondary accession number(s): P79320
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 25, 2017
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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