PDGFB

Functionⁱ

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	108	Involved in receptor binding		1
Siteⁱ	111	Involved in receptor binding		1

GO - Molecular functionⁱ

growth factor activity Source: UniProtKB
platelet-derived growth factor receptor binding Source: UniProtKB
protein homodimerization activity Source: UniProtKB
superoxide-generating NADPH oxidase activator activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of protein kinase activity Source: UniProtKB
activation of protein kinase B activity Source: UniProtKB
cell chemotaxis Source: UniProtKB
cellular response to mycophenolic acid Source: UniProtKB
embryonic placenta development Source: UniProtKB
heart development Source: UniProtKB
metanephric glomerular mesangial cell development Source: UniProtKB
monocyte chemotaxis Source: UniProtKB
negative regulation of phosphatidylinositol biosynthetic process Source: UniProtKB
negative regulation of platelet activation Source: UniProtKB
negative regulation of transcription, DNA-templated Source: UniProtKB
paracrine signaling Source: UniProtKB
peptidyl-serine phosphorylation Source: UniProtKB
peptidyl-tyrosine phosphorylation Source: UniProtKB
platelet-derived growth factor receptor signaling pathway Source: UniProtKB
positive regulation of blood vessel endothelial cell migration Source: UniProtKB
positive regulation of calcium ion import Source: UniProtKB
positive regulation of cell division Source: UniProtKB-KW
positive regulation of cell proliferation Source: UniProtKB
positive regulation of chemotaxis Source: UniProtKB
positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
positive regulation of DNA biosynthetic process Source: UniProtKB
positive regulation of endothelial cell proliferation Source: UniProtKB
positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
positive regulation of fibroblast proliferation Source: UniProtKB
positive regulation of glomerular filtration Source: UniProtKB
positive regulation of glomerular mesangial cell proliferation Source: UniProtKB
positive regulation of hyaluronan biosynthetic process Source: UniProtKB
positive regulation of MAPK cascade Source: UniProtKB
positive regulation of MAP kinase activity Source: UniProtKB
positive regulation of metanephric mesenchymal cell migration Source: UniProtKB
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway Source: UniProtKB
positive regulation of mitotic nuclear division Source: UniProtKB
positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
positive regulation of protein autophosphorylation Source: UniProtKB
positive regulation of protein tyrosine kinase activity Source: UniProtKB
positive regulation of reactive oxygen species metabolic process Source: UniProtKB
positive regulation of smooth muscle cell migration Source: UniProtKB
positive regulation of smooth muscle cell proliferation Source: UniProtKB
positive regulation of transcription, DNA-templated Source: UniProtKB
positive regulation of vascular smooth muscle cell proliferation Source: UniProtKB
protein phosphorylation Source: UniProtKB
reactive oxygen species metabolic process Source: UniProtKB
response to wounding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Growth factor, Mitogen

Molecular function

Developmental protein, Growth factor, Mitogen

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Platelet-derived growth factor subunit B Short name: PDGF subunit B Alternative name(s): PDGF-2 Platelet-derived growth factor B chain Platelet-derived growth factor beta polypeptide
Gene namesⁱ	Name:PDGFB
Organismⁱ	Ovis aries (Sheep)
Taxonomic identifierⁱ	9940 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis
Proteomesⁱ	UP000002356 Componentⁱ: Unplaced

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Proto-oncogene

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 20	By similarityAdd BLAST	20
PropeptideⁱPRO_0000023380	21 – 81	Removed in mature formBy similarityAdd BLAST	61
ChainⁱPRO_0000023381	82 – 190	Platelet-derived growth factor subunit BAdd BLAST	109
PropeptideⁱPRO_0000023382	191 – 241	Removed in mature formBy similarityAdd BLAST	51

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	63	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	97 ↔ 141	By similarity
Disulfide bondⁱ	124	InterchainBy similarity
Disulfide bondⁱ	130 ↔ 178	By similarity
Disulfide bondⁱ	133	InterchainBy similarity
Disulfide bondⁱ	134 ↔ 180	By similarity

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEⁱ	Q95229

PRIDEⁱ

Q95229

Interactionⁱ

Subunit structureⁱ

Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFA; antiparallel disulfide-linked dimer. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1 (By similarity).By similarity

GO - Molecular functionⁱ

growth factor activity Source: UniProtKB
platelet-derived growth factor receptor binding Source: UniProtKB
protein homodimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q95229
SMRⁱ	Q95229
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

HOVERGENⁱ	HBG053546
KEGG Orthology (KO) More...KOⁱ	K17386

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00135 PDGF, 1 hit
Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR023581 PD_growth_factor_CS IPR000072 PDGF/VEGF_dom IPR006782 PDGF_N IPR015583 PDGF_suB
PANTHERⁱ	PTHR11633:SF2 PTHR11633:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00341 PDGF, 1 hit PF04692 PDGF_N, 1 hit
SMARTⁱ	View protein in SMART SM00141 PDGF, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00249 PDGF_1, 1 hit PS50278 PDGF_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q95229-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNRCWALFLS LCCYLRLVSA EGDPIPEELY EMLSDHSIRS FDDLQRLLHG 
        60         70         80         90        100
DSLDEDGAEL DLNLTRSHSG GELESLSRGR RSLGSPTVAE PAVIAECKTR 
       110        120        130        140        150
TEVSEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQDRK 
       160        170        180        190        200
VQVKKIEIVR KKKIFKKATV TLVDHLACRC ETVMARAVTR TPGSSQEQRA 
       210        220        230        240 
ARTPQTRVTI RTVRVRRPPK GKHRKFKHTH DKTALKETLG A

Length:241

Mass (Da):27,331

Last modified:February 1, 1997 - v1

Checksum:ⁱ37BE1EC12E7D2863

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X97123 mRNA Translation: CAA65790.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001009471.1, NM_001009471.1
UniGeneⁱ	Oar.501

Genome annotation databases

GeneIDⁱ	443545
KEGGⁱ	oas:443545

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q95229	Platelet-derived growth factor subunit B	)	HUMAN		241	UniRef90_P01127
Platelet-derived growth factor subunit B		CANLF		242
platelet-derived growth factor subunit B isoform X1		DELLE		278
platelet-derived growth factor subunit B		Yangtze finless porpoise		209
Platelet-derived growth factor beta (Fragment)		MUSPF		245
+115

Protein	Similar proteins		Species	Score	Length	Source
Q95229	Platelet-derived growth factor subunit B	)	HUMAN		241	UniRef50_P01127
Platelet-derived growth factor subunit B		CANLF		242
Platelet-derived growth factor subunit B	)	MOUSE		241
Platelet-derived growth factor subunit B (Fragment)		RAT		225
PDGF-related-transforming protein sis		WMSV		226
+314

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X97123 mRNA Translation: CAA65790.1
RefSeqⁱ	NP_001009471.1, NM_001009471.1
UniGeneⁱ	Oar.501

3D structure databases

ProteinModelPortalⁱ	Q95229
SMRⁱ	Q95229
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	Q95229

PRIDEⁱ

Q95229

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	443545
KEGGⁱ	oas:443545

Organism-specific databases

CTDⁱ	5155

CTDⁱ

5155

Phylogenomic databases

HOVERGENⁱ	HBG053546
KOⁱ	K17386

Family and domain databases

CDDⁱ	cd00135 PDGF, 1 hit
Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR023581 PD_growth_factor_CS IPR000072 PDGF/VEGF_dom IPR006782 PDGF_N IPR015583 PDGF_suB
PANTHERⁱ	PTHR11633:SF2 PTHR11633:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF00341 PDGF, 1 hit PF04692 PDGF_N, 1 hit
SMARTⁱ	View protein in SMART SM00141 PDGF, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00249 PDGF_1, 1 hit PS50278 PDGF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PDGFB_SHEEP
Accessionⁱ	Q95229Primary (citable) accession number: Q95229
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	February 1, 1997
	Last modified:	July 18, 2018
	This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q95229 (PDGFB_SHEEP)

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Platelet-derived growth factor subunit B

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ