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Protein

Platelet-derived growth factor subunit B

Gene

PDGFB

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei108Involved in receptor binding1
Sitei111Involved in receptor binding1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-derived growth factor subunit B
Short name:
PDGF subunit B
Alternative name(s):
PDGF-2
Platelet-derived growth factor B chain
Platelet-derived growth factor beta polypeptide
Gene namesi
Name:PDGFB
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
PropeptideiPRO_000002338021 – 81Removed in mature formBy similarityAdd BLAST61
ChainiPRO_000002338182 – 190Platelet-derived growth factor subunit BAdd BLAST109
PropeptideiPRO_0000023382191 – 241Removed in mature formBy similarityAdd BLAST51

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 141By similarity
Disulfide bondi124InterchainBy similarity
Disulfide bondi130 ↔ 178By similarity
Disulfide bondi133InterchainBy similarity
Disulfide bondi134 ↔ 180By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ95229

Interactioni

Subunit structurei

Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFA; antiparallel disulfide-linked dimer. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1 (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ95229
SMRiQ95229
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG053546
KOiK17386

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
IPR006782 PDGF_N
IPR015583 PDGF_suB
PANTHERiPTHR11633:SF2 PTHR11633:SF2, 1 hit
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
PF04692 PDGF_N, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95229-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRCWALFLS LCCYLRLVSA EGDPIPEELY EMLSDHSIRS FDDLQRLLHG
60 70 80 90 100
DSLDEDGAEL DLNLTRSHSG GELESLSRGR RSLGSPTVAE PAVIAECKTR
110 120 130 140 150
TEVSEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQDRK
160 170 180 190 200
VQVKKIEIVR KKKIFKKATV TLVDHLACRC ETVMARAVTR TPGSSQEQRA
210 220 230 240
ARTPQTRVTI RTVRVRRPPK GKHRKFKHTH DKTALKETLG A
Length:241
Mass (Da):27,331
Last modified:February 1, 1997 - v1
Checksum:i37BE1EC12E7D2863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97123 mRNA Translation: CAA65790.1
RefSeqiNP_001009471.1, NM_001009471.1
UniGeneiOar.501

Genome annotation databases

GeneIDi443545
KEGGioas:443545

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97123 mRNA Translation: CAA65790.1
RefSeqiNP_001009471.1, NM_001009471.1
UniGeneiOar.501

3D structure databases

ProteinModelPortaliQ95229
SMRiQ95229
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ95229

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi443545
KEGGioas:443545

Organism-specific databases

CTDi5155

Phylogenomic databases

HOVERGENiHBG053546
KOiK17386

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
IPR006782 PDGF_N
IPR015583 PDGF_suB
PANTHERiPTHR11633:SF2 PTHR11633:SF2, 1 hit
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
PF04692 PDGF_N, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDGFB_SHEEP
AccessioniPrimary (citable) accession number: Q95229
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 18, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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