UniProtKB - Q95229 (PDGFB_SHEEP)
Platelet-derived growth factor subunit B
PDGFB
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 108 | Involved in receptor binding | 1 | |
Sitei | 111 | Involved in receptor binding | 1 |
GO - Molecular functioni
- growth factor activity Source: UniProtKB
- platelet-derived growth factor receptor binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- superoxide-generating NADPH oxidase activator activity Source: UniProtKB
GO - Biological processi
- activation of protein kinase activity Source: UniProtKB
- activation of protein kinase B activity Source: UniProtKB
- cell chemotaxis Source: UniProtKB
- cellular response to mycophenolic acid Source: UniProtKB
- embryonic placenta development Source: UniProtKB
- heart development Source: UniProtKB
- metanephric glomerular mesangial cell development Source: UniProtKB
- monocyte chemotaxis Source: UniProtKB
- negative regulation of phosphatidylinositol biosynthetic process Source: UniProtKB
- negative regulation of platelet activation Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- paracrine signaling Source: UniProtKB
- peptidyl-serine phosphorylation Source: UniProtKB
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- platelet-derived growth factor receptor signaling pathway Source: UniProtKB
- positive regulation of blood vessel endothelial cell migration Source: UniProtKB
- positive regulation of calcium ion import Source: UniProtKB
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of chemotaxis Source: UniProtKB
- positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
- positive regulation of DNA biosynthetic process Source: UniProtKB
- positive regulation of endothelial cell proliferation Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of fibroblast proliferation Source: UniProtKB
- positive regulation of glomerular filtration Source: UniProtKB
- positive regulation of glomerular mesangial cell proliferation Source: UniProtKB
- positive regulation of hyaluronan biosynthetic process Source: UniProtKB
- positive regulation of MAPK cascade Source: UniProtKB
- positive regulation of MAP kinase activity Source: UniProtKB
- positive regulation of metanephric mesenchymal cell migration Source: UniProtKB
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway Source: UniProtKB
- positive regulation of mitotic nuclear division Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of protein autophosphorylation Source: UniProtKB
- positive regulation of protein tyrosine kinase activity Source: UniProtKB
- positive regulation of reactive oxygen species metabolic process Source: UniProtKB
- positive regulation of smooth muscle cell migration Source: UniProtKB
- positive regulation of smooth muscle cell proliferation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of vascular associated smooth muscle cell proliferation Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- reactive oxygen species metabolic process Source: UniProtKB
- response to wounding Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, Growth factor, Mitogen |
Names & Taxonomyi
Protein namesi | Recommended name: Platelet-derived growth factor subunit BShort name: PDGF subunit B Alternative name(s): PDGF-2 Platelet-derived growth factor B chain Platelet-derived growth factor beta polypeptide |
Gene namesi | Name:PDGFB |
Organismi | Ovis aries (Sheep) |
Taxonomic identifieri | 9940 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Note: Released by platelets upon wounding.By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- basolateral plasma membrane Source: UniProtKB
Other locations
- cell surface Source: UniProtKB
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | By similarityAdd BLAST | 20 | |
PropeptideiPRO_0000023380 | 21 – 81 | Removed in mature formBy similarityAdd BLAST | 61 | |
ChainiPRO_0000023381 | 82 – 190 | Platelet-derived growth factor subunit BAdd BLAST | 109 | |
PropeptideiPRO_0000023382 | 191 – 241 | Removed in mature formBy similarityAdd BLAST | 51 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 63 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 141 | By similarity | ||
Disulfide bondi | 124 | InterchainBy similarity | ||
Disulfide bondi | 130 ↔ 178 | By similarity | ||
Disulfide bondi | 133 | InterchainBy similarity | ||
Disulfide bondi | 134 ↔ 180 | By similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinInteractioni
Subunit structurei
Antiparallel homodimer; disulfide-linked. Antiparallel heterodimer with PDGFA; disulfide-linked. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
Interacts with XLKD1 (By similarity).
Interacts with LRP1 (By similarity).
Interacts with SORL1 (via the N-terminal ectodomain) (By similarity).
By similarityGO - Molecular functioni
- growth factor activity Source: UniProtKB
- platelet-derived growth factor receptor binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9940.ENSOARP00000017621 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S2VW, Eukaryota |
OrthoDBi | 1439735at2759 |
Family and domain databases
CDDi | cd00135, PDGF, 1 hit |
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR023581, PD_growth_factor_CS IPR000072, PDGF/VEGF_dom IPR006782, PDGF_N IPR015583, PDGF_suB |
PANTHERi | PTHR11633:SF2, PTHR11633:SF2, 1 hit |
Pfami | View protein in Pfam PF00341, PDGF, 1 hit PF04692, PDGF_N, 1 hit |
SMARTi | View protein in SMART SM00141, PDGF, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00249, PDGF_1, 1 hit PS50278, PDGF_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MNRCWALFLS LCCYLRLVSA EGDPIPEELY EMLSDHSIRS FDDLQRLLHG
60 70 80 90 100
DSLDEDGAEL DLNLTRSHSG GELESLSRGR RSLGSPTVAE PAVIAECKTR
110 120 130 140 150
TEVSEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQDRK
160 170 180 190 200
VQVKKIEIVR KKKIFKKATV TLVDHLACRC ETVMARAVTR TPGSSQEQRA
210 220 230 240
ARTPQTRVTI RTVRVRRPPK GKHRKFKHTH DKTALKETLG A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97123 mRNA Translation: CAA65790.1 |
RefSeqi | NP_001009471.1, NM_001009471.1 |
Genome annotation databases
GeneIDi | 443545 |
KEGGi | oas:443545 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97123 mRNA Translation: CAA65790.1 |
RefSeqi | NP_001009471.1, NM_001009471.1 |
3D structure databases
SMRi | Q95229 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9940.ENSOARP00000017621 |
Genome annotation databases
GeneIDi | 443545 |
KEGGi | oas:443545 |
Organism-specific databases
CTDi | 5155 |
Phylogenomic databases
eggNOGi | ENOG502S2VW, Eukaryota |
OrthoDBi | 1439735at2759 |
Family and domain databases
CDDi | cd00135, PDGF, 1 hit |
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR023581, PD_growth_factor_CS IPR000072, PDGF/VEGF_dom IPR006782, PDGF_N IPR015583, PDGF_suB |
PANTHERi | PTHR11633:SF2, PTHR11633:SF2, 1 hit |
Pfami | View protein in Pfam PF00341, PDGF, 1 hit PF04692, PDGF_N, 1 hit |
SMARTi | View protein in SMART SM00141, PDGF, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00249, PDGF_1, 1 hit PS50278, PDGF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PDGFB_SHEEP | |
Accessioni | Q95229Primary (citable) accession number: Q95229 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families