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Entry version 101 (11 Dec 2019)
Sequence version 2 (01 May 1999)
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Protein

Deleted in malignant brain tumors 1 protein

Gene

Dmbt1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play roles in mucosal defense system and cellular immune defense. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. May function as a binding protein in saliva for the regulation of taste sensation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Protein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Deleted in malignant brain tumors 1 protein
Alternative name(s):
Hensin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dmbt1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000034368421 – 1594Deleted in malignant brain tumors 1 proteinAdd BLAST1574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi78 ↔ 142By similarity
Disulfide bondi91 ↔ 152By similarity
Disulfide bondi122 ↔ 132By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi217 ↔ 281By similarity
Disulfide bondi230 ↔ 291By similarity
Disulfide bondi261 ↔ 271By similarity
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi348 ↔ 412By similarity
Disulfide bondi361 ↔ 422By similarity
Disulfide bondi392 ↔ 402By similarity
Glycosylationi458N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi476 ↔ 540By similarity
Disulfide bondi489 ↔ 550By similarity
Disulfide bondi520 ↔ 530By similarity
Disulfide bondi607 ↔ 671By similarity
Disulfide bondi620 ↔ 681By similarity
Disulfide bondi651 ↔ 661By similarity
Glycosylationi717N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi738 ↔ 802By similarity
Disulfide bondi751 ↔ 812By similarity
Disulfide bondi782 ↔ 792By similarity
Disulfide bondi846 ↔ 910By similarity
Disulfide bondi859 ↔ 920By similarity
Disulfide bondi890 ↔ 900By similarity
Disulfide bondi951 ↔ 977By similarity
Disulfide bondi1004 ↔ 1025By similarity
Disulfide bondi1095 ↔ 1159By similarity
Disulfide bondi1108 ↔ 1169By similarity
Disulfide bondi1139 ↔ 1149By similarity
Disulfide bondi1192 ↔ 1218By similarity
Disulfide bondi1243 ↔ 1265By similarity
Disulfide bondi1479 ↔ 1537By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Highly N- and O-glycosylated. The O-glycans are heavily sulfated (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q95218

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in small intestine, liver, stomach and kidney. Present in small intestine and in collecting tubules of kidney cortex, medulla and papilla (at protein level).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LGALS3. Binds SFTPD and SPAR in a calcium-dependent manner (By similarity).

By similarity

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q95218

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 153SRCR 1PROSITE-ProRule annotationAdd BLAST101
Domaini192 – 292SRCR 2PROSITE-ProRule annotationAdd BLAST101
Domaini323 – 423SRCR 3PROSITE-ProRule annotationAdd BLAST101
Domaini454 – 551SRCR 4PROSITE-ProRule annotationAdd BLAST98
Domaini582 – 682SRCR 5PROSITE-ProRule annotationAdd BLAST101
Domaini713 – 813SRCR 6PROSITE-ProRule annotationAdd BLAST101
Domaini821 – 921SRCR 7PROSITE-ProRule annotationAdd BLAST101
Domaini951 – 1061CUB 1PROSITE-ProRule annotationAdd BLAST111
Domaini1067 – 1170SRCR 8PROSITE-ProRule annotationAdd BLAST104
Domaini1192 – 1301CUB 2PROSITE-ProRule annotationAdd BLAST110
Domaini1310 – 1558ZPPROSITE-ProRule annotationAdd BLAST249

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi41 – 44Poly-Thr4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SRCR domains mediate binding to bacteria.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DMBT1 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q95218

KEGG Orthology (KO)

More...
KOi
K13912

Database of Orthologous Groups

More...
OrthoDBi
1095487at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041 CUB, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 2 hits
3.10.250.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001507 ZP_dom
IPR017977 ZP_dom_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 2 hits
PF00530 SRCR, 8 hits
PF00100 Zona_pellucida, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00258 SPERACTRCPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042 CUB, 2 hits
SM00202 SR, 8 hits
SM00241 ZP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854 SSF49854, 2 hits
SSF56487 SSF56487, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180 CUB, 2 hits
PS00420 SRCR_1, 6 hits
PS50287 SRCR_2, 8 hits
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q95218-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGISTVLALS LLWGPALSQG QWIPYTTYHD SVSSPGAPVE TTTTEVFPSG
60 70 80 90 100
LELRLANGGD RCQGRVEVLY QGSWGTVCDD GWDINDAQVV CRQLGCGMAV
110 120 130 140 150
SAPGSARFGQ GPGQIVLDDV SCSGQEPYLW SCHHRGWLSH NCGHQEDAGV
160 170 180 190 200
ICSDAMAMTS PPPDTWPTTV IYESTPHFPS GLELVFPSGL ELRLANGSDR
210 220 230 240 250
CQGRVEVLYQ GSWGTVCDDG WDINDAQVVC RQLGCGMAVS APGSARFGQG
260 270 280 290 300
PGQIVLDDVS CSGQEPYLWS CHHRGWLSHN CGHQEDAGVI CSDAVPTTTP
310 320 330 340 350
PPDTWPTTVI YESSPVFPSG LELRLANGSD RCQGRVEVLY QGSWGTVCDD
360 370 380 390 400
GWDINDAQVV CRQLGCGTAV SAPGSARFGQ GPGQIVLDDV SCSGQEPYLW
410 420 430 440 450
SCHHRGWLSH NCGHQEDAGV ICSDAMAMTT PLPDTWPTTV IHESTPVFPS
460 470 480 490 500
GLELQLANGS DRCQGRVEVL YQGTVCDDGW DINDAQVVCR QLGCGMAVSA
510 520 530 540 550
PGSARFGQGP GQIVLDDVSC SGQEPYLWSC HHRGWLSHNC GHQEDAGVIC
560 570 580 590 600
SDAMAMTTPP PDTWPTTVIY ESTPHFPSGL ELRLANGSDR CQGRVEVLYQ
610 620 630 640 650
GSWGTVCDDG WDINDAQVVC RQLGCGTAVS APGSARFGQG PGQIVLDDVS
660 670 680 690 700
CSGQEPYLWS CHHRGWLSHN CGHQEDAGVI CSGAMDTTTP LPDTWPTTVI
710 720 730 740 750
YESTPVHISG LQLRLVNGSD RCEGRVEVLY QGSWGTVCDD SWDLNDASVV
760 770 780 790 800
CRQLGCGTAL SAPASAQFGQ SSGSIVLDDV SCSGSEPNLW SCSHRGWLSH
810 820 830 840 850
NCGHHEDAGV VCSGPDSRLA VRLVNGSTRC QGRVEVLYRG SWGTVCDDSW
860 870 880 890 900
DINDASVVCR QLGCGWAVSA PGSARFGQGS GSIFLDEVSC SGQEPYLWNC
910 920 930 940 950
SHRGWLSHNC GHYEDAGVIC SDGWTTVTPP APTTDWWEPT VTTTVGPSSN
960 970 980 990 1000
CGGFLYNATG SFSSPSYPGY YPNNALCVWE IAVPSGYLIN LGFSQLRLEQ
1010 1020 1030 1040 1050
HSYCNFDYVE IFDGSTDSSL LGKICNDSGQ IFTTSSNRMT VLFRSDISVQ
1060 1070 1080 1090 1100
NTGFLAWYNS FPRDASLRLV SGNSSYGACA GRVEIYHGGR WGTVCDDSWD
1110 1120 1130 1140 1150
TQDAQVVCRQ LQCGDAVSAP GGAYFGSGSG PITLDDVNCS GTEATLWQCR
1160 1170 1180 1190 1200
SQSWFSHNCG HHEDASVICT GNYGTTTASV PNISTSNASY SCGGFLSQHS
1210 1220 1230 1240 1250
GRFSSPFYPG NYPNNARCVW DIEVQNNYQV TVTFTDVQLE GGCQYDYIEV
1260 1270 1280 1290 1300
FDGPYHSSPL IARVCDGARG SFTSSSNFLS VRFVSDGSIT RRGFQAEFYS
1310 1320 1330 1340 1350
LPSNDSTNLL CLMNHMQASV SRAYLQSLGF SAWELVVSGW NGNYQCQRQI
1360 1370 1380 1390 1400
TPSQVIFTIP YSGCGTIKQV DNETITYSNF LKAAVSSGVI KRKKDLHIHV
1410 1420 1430 1440 1450
SCRMLQDSWV HTMYIANDTI EVSEVQYSNF NVNVSFYTSS SFSYPVTSSP
1460 1470 1480 1490 1500
YYVDLDQNLY LQAEILHSDA SLALFVDTCV ASPNPNDFTS VTYDLIRSGC
1510 1520 1530 1540 1550
VRDETYRSYA QPSPRVVRFR FNSFHFLNRF PAVYLRCKMV VCRAYDYSSR
1560 1570 1580 1590
CYRGCVVRSK RDVGSYQERV DVVLGPIQLL DPPAGKKSPG KGSP
Length:1,594
Mass (Da):172,764
Last modified:May 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i29D6BEFEAA987CC4
GO
Isoform 2 (identifier: Q95218-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-302: EVFPSGLELR...DAVPTTTPPP → TE
     361-488: Missing.

Show »
Length:1,210
Mass (Da):131,796
Checksum:iB828FA4591364322
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti40E → EA in AAD50330 (PubMed:10444583).Curated1
Sequence conflicti41T → A in AAD50332 (PubMed:10444583).Curated1
Sequence conflicti41T → A in AAD50331 (PubMed:10444583).Curated1
Sequence conflicti160S → T in AAD50330 (PubMed:10444583).Curated1
Sequence conflicti177 – 185HFPSGLELV → L in AAD50330 (PubMed:10444583).Curated9
Sequence conflicti198S → G in AAD50330 (PubMed:10444583).Curated1
Sequence conflicti314S → T in AAD50332 (PubMed:10444583).Curated1
Sequence conflicti314S → T in AAD50331 (PubMed:10444583).Curated1
Sequence conflicti329S → G in AAD50332 (PubMed:10444583).Curated1
Sequence conflicti329S → G in AAD50331 (PubMed:10444583).Curated1
Sequence conflicti575H → L in AAD50332 (PubMed:10444583).Curated1
Sequence conflicti575H → L in AAD50331 (PubMed:10444583).Curated1
Sequence conflicti588S → G in AAD50332 (PubMed:10444583).Curated1
Sequence conflicti588S → G in AAD50331 (PubMed:10444583).Curated1
Sequence conflicti627T → M in AAD50332 (PubMed:10444583).Curated1
Sequence conflicti627T → M in AAD50331 (PubMed:10444583).Curated1
Sequence conflicti744L → I AA sequence (PubMed:8941650).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03465845 – 302EVFPS…TTPPP → TE in isoform 2. 1 PublicationAdd BLAST258
Alternative sequenceiVSP_034659361 – 488Missing in isoform 2. 1 PublicationAdd BLAST128

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF043112 mRNA Translation: AAD02242.1
AF078900 Genomic DNA Translation: AAD50330.1
AF078900 Genomic DNA Translation: AAD50331.1
AF078900 Genomic DNA Translation: AAD50332.1

Protein sequence database of the Protein Information Resource

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PIRi
T30549

NCBI Reference Sequences

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RefSeqi
NP_001075502.1, NM_001082033.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
100008679

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ocu:100008679

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043112 mRNA Translation: AAD02242.1
AF078900 Genomic DNA Translation: AAD50330.1
AF078900 Genomic DNA Translation: AAD50331.1
AF078900 Genomic DNA Translation: AAD50332.1
PIRiT30549
RefSeqiNP_001075502.1, NM_001082033.1

3D structure databases

SMRiQ95218
ModBaseiSearch...

Proteomic databases

PRIDEiQ95218

Genome annotation databases

GeneIDi100008679
KEGGiocu:100008679

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1755

Phylogenomic databases

InParanoidiQ95218
KOiK13912
OrthoDBi1095487at2759

Family and domain databases

CDDicd00041 CUB, 2 hits
Gene3Di2.60.120.290, 2 hits
3.10.250.10, 8 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF00530 SRCR, 8 hits
PF00100 Zona_pellucida, 1 hit
PRINTSiPR00258 SPERACTRCPTR
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00202 SR, 8 hits
SM00241 ZP, 1 hit
SUPFAMiSSF49854 SSF49854, 2 hits
SSF56487 SSF56487, 8 hits
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS00420 SRCR_1, 6 hits
PS50287 SRCR_2, 8 hits
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDMBT1_RABIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q95218
Secondary accession number(s): Q95219
, Q9TV20, Q9TV21, Q9TV22
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 1, 1999
Last modified: December 11, 2019
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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