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Protein

Long-wave-sensitive opsin 1

Gene

OPN1LW

Organism
Capra hircus (Goat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

Absorptioni

Abs(max)=553 nm

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological processSensory transduction, Vision
LigandChromophore

Names & Taxonomyi

Protein namesi
Recommended name:
Long-wave-sensitive opsin 1
Alternative name(s):
Red cone photoreceptor pigment
Red-sensitive opsin
Gene namesi
Name:OPN1LW
Synonyms:RCP
OrganismiCapra hircus (Goat)
Taxonomic identifieri9925 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52ExtracellularAdd BLAST52
Transmembranei53 – 77Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini78 – 89CytoplasmicAdd BLAST12
Transmembranei90 – 115Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini116 – 129ExtracellularAdd BLAST14
Transmembranei130 – 149Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini150 – 168CytoplasmicAdd BLAST19
Transmembranei169 – 192Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini193 – 218ExtracellularAdd BLAST26
Transmembranei219 – 246Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini247 – 268CytoplasmicAdd BLAST22
Transmembranei269 – 292Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini293 – 300Extracellular8
Transmembranei301 – 325Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini326 – 364CytoplasmicAdd BLAST39

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001977991 – 364Long-wave-sensitive opsin 1Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi126 ↔ 203PROSITE-ProRule annotation
Modified residuei312N6-(retinylidene)lysineBy similarity1

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Expressioni

Tissue specificityi

The three color pigments are found in the cone photoreceptor cells.

Structurei

3D structure databases

ProteinModelPortaliQ95170
SMRiQ95170
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG107442
KOiK04251
OrthoDBiEOG091G0BDA

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001760 Opsin
IPR000378 Opsin_red/grn
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00238 OPSIN
PR00575 OPSINREDGRN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q95170-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHTWGPQRL AGGQPQANFE ESTQGSIFTY TNSNSTRDPF EGPNYHIAPR
60 70 80 90 100
WVYHLTSAWM VFVVIASVFT NGLVLAATMR FKKLRHPLNW ILVNLAIADL
110 120 130 140 150
AETIIASTIS VVNQMYGYFV LGHPLCVVEG YTVSLCGITG LWSLAIISWE
160 170 180 190 200
RWMVVCKPFG NVRFDAKLAT AGIAFSWIWA AVWTAPPIFG WSRYWPHGLK
210 220 230 240 250
TSCGPDVFSG SSYPGVQSYM IVLMITCCFI PLSVIILCYL QVWLAIRAVA
260 270 280 290 300
KQQKESESTQ KAEKEVTRMV MVMIFAYCLC WGPYTFFACF AAAHPGYAFH
310 320 330 340 350
PLVAALPAYF AKSATIYNPI IYVFMNRQFR NCILQLFGKK VDDSSELSSV
360
SKTEASSVSS VSPA
Length:364
Mass (Da):40,572
Last modified:February 1, 1997 - v1
Checksum:i19664C5313A40E96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68004
, U67999, U68000, U68001, U68002, U68003 Genomic DNA Translation: AAC48773.1
RefSeqiXP_005701795.1, XM_005701738.2

Genome annotation databases

EnsembliENSCHIT00000022014; ENSCHIP00000014220; ENSCHIG00000015283
GeneIDi102175286
KEGGichx:102175286

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68004
, U67999, U68000, U68001, U68002, U68003 Genomic DNA Translation: AAC48773.1
RefSeqiXP_005701795.1, XM_005701738.2

3D structure databases

ProteinModelPortaliQ95170
SMRiQ95170
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCHIT00000022014; ENSCHIP00000014220; ENSCHIG00000015283
GeneIDi102175286
KEGGichx:102175286

Phylogenomic databases

HOVERGENiHBG107442
KOiK04251
OrthoDBiEOG091G0BDA

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001760 Opsin
IPR000378 Opsin_red/grn
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00238 OPSIN
PR00575 OPSINREDGRN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOPSR_CAPHI
AccessioniPrimary (citable) accession number: Q95170
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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