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Protein

Pigment epithelium-derived factor

Gene

SERPINF1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPSiI04.979

Names & Taxonomyi

Protein namesi
Recommended name:
Pigment epithelium-derived factor
Short name:
PEDF
Alternative name(s):
Serpin F1
Gene namesi
Name:SERPINF1
Synonyms:PEDF
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:34478 SERPINF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000003250721 – 416Pigment epithelium-derived factorAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112PhosphoserineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ95121
PeptideAtlasiQ95121
PRIDEiQ95121

Expressioni

Tissue specificityi

Retinal pigment epithelial cells. Located in the interphotoreceptor matrix (IPM) which is between the retinal pigment epithelium and the neural retina.

Gene expression databases

BgeeiENSBTAG00000009705 Expressed in 10 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012804

Structurei

3D structure databases

ProteinModelPortaliQ95121
SMRiQ95121
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal (AA 42-139) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 380-416) is essential for serpin activity.

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00920000149046
HOGENOMiHOG000115489
HOVERGENiHBG106911
InParanoidiQ95121
KOiK19614
OMAiLNCKIAQ
OrthoDBiEOG091G09UU
TreeFamiTF317350

Family and domain databases

CDDicd02052 PEDF, 1 hit
InterProiView protein in InterPro
IPR033832 PEDF
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95121-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQALVLLLWT GALLGFGRCQ NAGQEAGSLT PESTGAPVEE EDPFFKVPVN
60 70 80 90 100
KLAAAVSNFG YDLYRVRSGE SPTANVLLSP LSVATALSAL SLGAEQRTES
110 120 130 140 150
NIHRALYYDL ISNPDIHGTY KDLLASVTAP QKNLKSASRI IFERKLRIKA
160 170 180 190 200
SFIPPLEKSY GTRPRILTGN SRVDLQEINN WVQAQMKGKV ARSTREMPSE
210 220 230 240 250
ISIFLLGVAY FKGQWVTKFD SRKTSLEDFY LDEERTVKVP MMSDPQAVLR
260 270 280 290 300
YGLDSDLNCK IAQLPLTGST SIIFFLPQKV TQNLTLIEES LTSEFIHDID
310 320 330 340 350
RELKTVQAVL TIPKLKLSYE GELTKSVQEL KLQSLFDAPD FSKITGKPIK
360 370 380 390 400
LTQVEHRVGF EWNEDGAGTN SSPGVQPARL TFPLDYHLNQ PFIFVLRDTD
410
TGALLFIGKI LDPRGT
Length:416
Mass (Da):46,229
Last modified:February 1, 1997 - v1
Checksum:iF6C76B6A4C9A4ECA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21N → D AA sequence (PubMed:7592790).Curated1
Sequence conflicti46K → R AA sequence (PubMed:7592790).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48229 mRNA Translation: AAC48856.1
AF017058 mRNA Translation: AAC05732.1
BC112656 mRNA Translation: AAI12657.1
RefSeqiNP_776565.1, NM_174140.3
UniGeneiBt.2638

Genome annotation databases

EnsembliENSBTAT00000012804; ENSBTAP00000012804; ENSBTAG00000009705
GeneIDi281386
KEGGibta:281386

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48229 mRNA Translation: AAC48856.1
AF017058 mRNA Translation: AAC05732.1
BC112656 mRNA Translation: AAI12657.1
RefSeqiNP_776565.1, NM_174140.3
UniGeneiBt.2638

3D structure databases

ProteinModelPortaliQ95121
SMRiQ95121
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012804

Protein family/group databases

MEROPSiI04.979

Proteomic databases

PaxDbiQ95121
PeptideAtlasiQ95121
PRIDEiQ95121

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012804; ENSBTAP00000012804; ENSBTAG00000009705
GeneIDi281386
KEGGibta:281386

Organism-specific databases

CTDi5176
VGNCiVGNC:34478 SERPINF1

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00920000149046
HOGENOMiHOG000115489
HOVERGENiHBG106911
InParanoidiQ95121
KOiK19614
OMAiLNCKIAQ
OrthoDBiEOG091G09UU
TreeFamiTF317350

Gene expression databases

BgeeiENSBTAG00000009705 Expressed in 10 organ(s), highest expression level in liver

Family and domain databases

CDDicd02052 PEDF, 1 hit
InterProiView protein in InterPro
IPR033832 PEDF
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPEDF_BOVIN
AccessioniPrimary (citable) accession number: Q95121
Secondary accession number(s): Q2KIF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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