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Protein

Proteasome subunit alpha type-5

Gene

pas-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-6798695 Neutrophil degranulation
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-5 (EC:3.4.25.1)
Short name:
Proteasome subunit alpha 5
Gene namesi
Name:pas-5
ORF Names:F25H2.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF25H2.9 ; CE09654 ; WBGene00003926 ; pas-5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241201 – 248Proteasome subunit alpha type-5Add BLAST248

Proteomic databases

EPDiQ95008
PaxDbiQ95008
PeptideAtlasiQ95008
PRIDEiQ95008

2D gel databases

World-2DPAGEi0020:Q95008

Expressioni

Gene expression databases

BgeeiWBGene00003926

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
pas-4Q950053EBI-320441,EBI-316796

Protein-protein interaction databases

BioGridi38356, 5 interactors
DIPiDIP-24675N
IntActiQ95008, 4 interactors
STRINGi6239.F25H2.9.3

Structurei

3D structure databases

ProteinModelPortaliQ95008
SMRiQ95008
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0176 Eukaryota
COG0638 LUCA
GeneTreeiENSGT00550000074958
HOGENOMiHOG000091085
InParanoidiQ95008
KOiK02729
OMAiFQVEYAR
OrthoDBiEOG091G0GX6
PhylomeDBiQ95008

Family and domain databases

CDDicd03753 proteasome_alpha_type_5, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR033812 Proteasome_alpha_type_5
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q95008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLTRSEYDR GVNTFSPEGR LFQVEYAIEA VKLGSTSIGI KTSEGVLLAA
60 70 80 90 100
EKRSTSKLMV NDAIEKISKV DQHIGVTFAG LIADSRTLVE RAQIEAQNFW
110 120 130 140 150
FTYNRKIRVE DVTQSVANLA LQFGDDDVKA SMSRPFGVAM LFAGVDQEGA
160 170 180 190 200
KLFHLDPSGT FIDCKAKSIG AASDGAEQNL KEQYHDALTI KEGLKMALAI
210 220 230 240
LKQVMEEKLN SANVEVVVIK PTVDAKGRPI GEFTRVSNEE LDQVITSL
Length:248
Mass (Da):27,207
Last modified:February 1, 1997 - v1
Checksum:iEFE50A1EB8546470
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79754 Genomic DNA Translation: CAB02097.1
PIRiT21350
RefSeqiNP_492765.1, NM_060364.6
UniGeneiCel.18396

Genome annotation databases

EnsemblMetazoaiF25H2.9; F25H2.9; WBGene00003926
GeneIDi172942
KEGGicel:CELE_F25H2.9
UCSCiF25H2.9 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPSA5_CAEEL
AccessioniPrimary (citable) accession number: Q95008
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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