UniProtKB - Q95003 (GPX3_CAEEL)
Protein
Glutathione peroxidase 3
Gene
gpx-3
Organism
Caenorhabditis elegans
Status
Functioni
Catalytic activityi
- EC:1.11.1.9
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 73 | By similarity | 1 |
GO - Molecular functioni
- glutathione peroxidase activity Source: GO_Central
- peroxidase activity Source: GO_Central
GO - Biological processi
- response to oxidative stress Source: InterPro
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Enzyme and pathway databases
Reactomei | R-CEL-3299685 Detoxification of Reactive Oxygen Species |
Protein family/group databases
PeroxiBasei | 3748 CelGPx03 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:gpx-3 ORF Names:C11E4.2 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | C11E4.2 ; CE08102 ; WBGene00007517 ; gpx-3 |
Subcellular locationi
Extracellular region or secreted
- extracellular space By similarity
Extracellular region or secreted
- extracellular space Source: WormBase
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000013090 | 19 – 224 | Glutathione peroxidase 3Add BLAST | 206 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 38 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q95003 |
PeptideAtlasi | Q95003 |
Expressioni
Gene expression databases
Bgeei | WBGene00007517 Expressed in 4 organ(s), highest expression level in multi-cellular organism |
Family & Domainsi
Sequence similaritiesi
Belongs to the glutathione peroxidase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1651 Eukaryota COG0386 LUCA |
GeneTreei | ENSGT00970000196088 |
HOGENOMi | HOG000277055 |
InParanoidi | Q95003 |
KOi | K00432 |
OMAi | LVAFPCN |
OrthoDBi | 1483113at2759 |
PhylomeDBi | Q95003 |
Family and domain databases
CDDi | cd00340 GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889 Glutathione_peroxidase IPR029759 GPX_AS IPR029760 GPX_CS IPR036249 Thioredoxin-like_sf |
PANTHERi | PTHR11592 PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255 GSHPx, 1 hit |
PIRSFi | PIRSF000303 Glutathion_perox, 1 hit |
PRINTSi | PR01011 GLUTPROXDASE |
SUPFAMi | SSF52833 SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460 GLUTATHIONE_PEROXID_1, 1 hit PS00763 GLUTATHIONE_PEROXID_2, 1 hit PS51355 GLUTATHIONE_PEROXID_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q95003-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPGSVLSLA VALATIIGIS CTATVDETMR WKECLNTNQS IFDFQIETLQ
60 70 80 90 100
GEYTDLSQYR GKVILLVNVA TFCAYTQQYT DFNPMLEKYQ AQGLTLVAFP
110 120 130 140 150
CNQFYLQEPA ENHELMNGLT YVRPGNGWTP HQELHIYGKI DVNGDNHHPL
160 170 180 190 200
YEFVKESCPQ TVDKIGKTDE LMYNPVRPSD ITWNFEKFLI DRNGQPRFRF
210 220
HPTAWSHGDV VTPFIEQLLA EPAN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z81015 Genomic DNA Translation: CAB02655.1 |
PIRi | T19190 |
RefSeqi | NP_509616.1, NM_077215.4 |
Genome annotation databases
EnsemblMetazoai | C11E4.2.1; C11E4.2.1; WBGene00007517 |
GeneIDi | 182513 |
KEGGi | cel:CELE_C11E4.2 |
UCSCi | C11E4.2 c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z81015 Genomic DNA Translation: CAB02655.1 |
PIRi | T19190 |
RefSeqi | NP_509616.1, NM_077215.4 |
3D structure databases
SMRi | Q95003 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 6239.C11E4.2 |
Protein family/group databases
PeroxiBasei | 3748 CelGPx03 |
Proteomic databases
PaxDbi | Q95003 |
PeptideAtlasi | Q95003 |
Genome annotation databases
EnsemblMetazoai | C11E4.2.1; C11E4.2.1; WBGene00007517 |
GeneIDi | 182513 |
KEGGi | cel:CELE_C11E4.2 |
UCSCi | C11E4.2 c. elegans |
Organism-specific databases
CTDi | 182513 |
WormBasei | C11E4.2 ; CE08102 ; WBGene00007517 ; gpx-3 |
Phylogenomic databases
eggNOGi | KOG1651 Eukaryota COG0386 LUCA |
GeneTreei | ENSGT00970000196088 |
HOGENOMi | HOG000277055 |
InParanoidi | Q95003 |
KOi | K00432 |
OMAi | LVAFPCN |
OrthoDBi | 1483113at2759 |
PhylomeDBi | Q95003 |
Enzyme and pathway databases
Reactomei | R-CEL-3299685 Detoxification of Reactive Oxygen Species |
Miscellaneous databases
PROi | PR:Q95003 |
Gene expression databases
Bgeei | WBGene00007517 Expressed in 4 organ(s), highest expression level in multi-cellular organism |
Family and domain databases
CDDi | cd00340 GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889 Glutathione_peroxidase IPR029759 GPX_AS IPR029760 GPX_CS IPR036249 Thioredoxin-like_sf |
PANTHERi | PTHR11592 PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255 GSHPx, 1 hit |
PIRSFi | PIRSF000303 Glutathion_perox, 1 hit |
PRINTSi | PR01011 GLUTPROXDASE |
SUPFAMi | SSF52833 SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460 GLUTATHIONE_PEROXID_1, 1 hit PS00763 GLUTATHIONE_PEROXID_2, 1 hit PS51355 GLUTATHIONE_PEROXID_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPX3_CAEEL | |
Accessioni | Q95003Primary (citable) accession number: Q95003 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | February 1, 1997 | |
Last modified: | November 13, 2019 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase