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Protein

Protein COBRA

Gene

COB

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in determining the orientation of cell expansion, probably by playing an important role in cellulose deposition. May act by recruiting cellulose synthesizing complexes to discrete positions on the cell surface.

Miscellaneous

A partial protein missing the N-terminal signal peptide was reported to complement a yeast mutant defective in phytochelatin synthesis. It is therefore possible that COBRA binds divalent metals.

GO - Biological processi

  • cellulose microfibril organization Source: TAIR
  • multidimensional cell growth Source: TAIR
  • response to salt stress Source: TAIR

Names & Taxonomyi

Protein namesi
Recommended name:
Protein COBRA
Alternative name(s):
Cell expansion protein
Gene namesi
Name:COB
Ordered Locus Names:At5g60920
ORF Names:MSL3.40
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G60920
TAIRilocus:2173532 AT5G60920

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Sequence analysisAdd BLAST36
ChainiPRO_000000557037 – 431Protein COBRAAdd BLAST395
PropeptideiPRO_0000005571432 – 456Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi431GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ94KT8
PRIDEiQ94KT8

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves, flowers and siliques. Up-regulated in the root zone of rapid longitudinal expansion.2 Publications

Gene expression databases

ExpressionAtlasiQ94KT8 baseline and differential
GenevisibleiQ94KT8 AT

Interactioni

Protein-protein interaction databases

BioGridi21457, 1 interactor
STRINGi3702.AT5G60920.1

Family & Domainsi

Sequence similaritiesi

Belongs to the COBRA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHWU Eukaryota
ENOG410YAAC LUCA
HOGENOMiHOG000231433
InParanoidiQ94KT8
OMAiGVMNSWV
OrthoDBiEOG093607TM
PhylomeDBiQ94KT8

Family and domain databases

InterProiView protein in InterPro
IPR006918 COBRA_pln
PANTHERiPTHR31673 PTHR31673, 1 hit
PfamiView protein in Pfam
PF04833 COBRA, 1 hit
PIRSFiPIRSF038122 COBRA, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD140986 GPI-anchored_pln, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q94KT8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESFFSRSTS IVSKLSFLAL WIVFLISSSS FTSTEAYDAL DPEGNITMKW
60 70 80 90 100
DVMSWTPDGY VAVVTMFNFQ KYRHIQSPGW TLGWKWAKKE VIWSMVGAQT
110 120 130 140 150
TEQGDCSKYK GNIPHCCKKD PTVVDLLPGT PYNQQIANCC KGGVMNSWVQ
160 170 180 190 200
DPATAASSFQ ISVGAAGTTN KTVRVPRNFT LMGPGPGYTC GPAKIVRPTK
210 220 230 240 250
FVTTDTRRTT QAMMTWNITC TYSQFLAQRT PTCCVSLSSF YNETIVGCPT
260 270 280 290 300
CACGCQNNRT ESGACLDPDT PHLASVVSPP TKKGTVLPPL VQCTRHMCPI
310 320 330 340 350
RVHWHVKQNY KEYWRVKITI TNFNYRLNYT QWNLVAQHPN LDNITQIFSF
360 370 380 390 400
NYKSLTPYAG LNDTAMLWGV KFYNDFLSEA GPLGNVQSEI LFRKDQSTFT
410 420 430 440 450
FEKGWAFPRR IYFNGDNCVM PPPDSYPFLP NGGSRSQFSF VAAVLLPLLV

FFFFSA
Length:456
Mass (Da):51,203
Last modified:December 1, 2001 - v1
Checksum:i9868B40C2E76D2C3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8BCB5A0A1P8BCB5_ARATH
COBRA-like protein
COB COBRA, MSL3.40, MSL3_40, At5g60920
409Annotation score:

Sequence cautioni

The sequence BAB10641 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA07251 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319663 Genomic DNA Translation: AAK56072.1
AB008269 Genomic DNA Translation: BAB10641.1 Sequence problems.
CP002688 Genomic DNA Translation: AED97397.1
AY094402 mRNA Translation: AAM19781.1
BT001119 mRNA Translation: AAN64510.1
AY085712 mRNA Translation: AAM62930.1
AJ006787 mRNA Translation: CAA07251.1 Different initiation.
PIRiT52038
RefSeqiNP_568930.1, NM_125485.4
UniGeneiAt.21375

Genome annotation databases

EnsemblPlantsiAT5G60920.1; AT5G60920.1; AT5G60920
GeneIDi836213
GrameneiAT5G60920.1; AT5G60920.1; AT5G60920
KEGGiath:AT5G60920

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319663 Genomic DNA Translation: AAK56072.1
AB008269 Genomic DNA Translation: BAB10641.1 Sequence problems.
CP002688 Genomic DNA Translation: AED97397.1
AY094402 mRNA Translation: AAM19781.1
BT001119 mRNA Translation: AAN64510.1
AY085712 mRNA Translation: AAM62930.1
AJ006787 mRNA Translation: CAA07251.1 Different initiation.
PIRiT52038
RefSeqiNP_568930.1, NM_125485.4
UniGeneiAt.21375

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi21457, 1 interactor
STRINGi3702.AT5G60920.1

Proteomic databases

PaxDbiQ94KT8
PRIDEiQ94KT8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G60920.1; AT5G60920.1; AT5G60920
GeneIDi836213
GrameneiAT5G60920.1; AT5G60920.1; AT5G60920
KEGGiath:AT5G60920

Organism-specific databases

AraportiAT5G60920
TAIRilocus:2173532 AT5G60920

Phylogenomic databases

eggNOGiENOG410IHWU Eukaryota
ENOG410YAAC LUCA
HOGENOMiHOG000231433
InParanoidiQ94KT8
OMAiGVMNSWV
OrthoDBiEOG093607TM
PhylomeDBiQ94KT8

Miscellaneous databases

PROiPR:Q94KT8

Gene expression databases

ExpressionAtlasiQ94KT8 baseline and differential
GenevisibleiQ94KT8 AT

Family and domain databases

InterProiView protein in InterPro
IPR006918 COBRA_pln
PANTHERiPTHR31673 PTHR31673, 1 hit
PfamiView protein in Pfam
PF04833 COBRA, 1 hit
PIRSFiPIRSF038122 COBRA, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD140986 GPI-anchored_pln, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOBRA_ARATH
AccessioniPrimary (citable) accession number: Q94KT8
Secondary accession number(s): O81811, Q8LDZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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