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Entry version 139 (18 Sep 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Two pore calcium channel protein 1

Gene

TPC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a voltage-gated inward-rectifying Ca2+ channel (VDCC) across the vacuole membrane. Is one of the essential components of the slow vacuolar (SV) channel. Acts as the major ROS-responsive Ca2+ channel and is the possible target of Al-dependent inhibition. Involved in the regulation of germination and stomatal movement.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by Al3+.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.11.26 the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Two pore calcium channel protein 1
Alternative name(s):
Calcium channel protein 1
Short name:
AtCCH1
Fatty acid oxygenation up-regulated protein 2
Voltage-dependent calcium channel protein TPC1
Short name:
AtTPC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPC1
Synonyms:CCH1, FOU2
Ordered Locus Names:At4g03560
ORF Names:F9H3.19, T5L23.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G03560

The Arabidopsis Information Resource

More...
TAIRi
locus:2128716 AT4G03560

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 71CytoplasmicSequence analysisAdd BLAST71
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei72 – 92Helical; Name=S1 of repeat ISequence analysisAdd BLAST21
Topological domaini93 – 120VacuolarSequence analysisAdd BLAST28
Transmembranei121 – 141Helical; Name=S2 of repeat ISequence analysisAdd BLAST21
Topological domaini142 – 158CytoplasmicSequence analysisAdd BLAST17
Transmembranei159 – 179Helical; Name=S3 of repeat ISequence analysisAdd BLAST21
Topological domaini180VacuolarSequence analysis1
Transmembranei181 – 199Helical; Voltage-sensor; Name=S4 of repeat ISequence analysisAdd BLAST19
Topological domaini200 – 218CytoplasmicSequence analysisAdd BLAST19
Transmembranei219 – 239Helical; Name=S5 of repeat ISequence analysisAdd BLAST21
Topological domaini240 – 245VacuolarSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei246 – 260Pore-forming; Name=Pore-forming 1Add BLAST15
Topological domaini261 – 282VacuolarSequence analysisAdd BLAST22
Transmembranei283 – 303Helical; Name=S6 of repeat ISequence analysisAdd BLAST21
Topological domaini304 – 428CytoplasmicSequence analysisAdd BLAST125
Transmembranei429 – 449Helical; Name=S1 of repeat IISequence analysisAdd BLAST21
Topological domaini450 – 465VacuolarSequence analysisAdd BLAST16
Transmembranei466 – 486Helical; Name=S2 of repeat IISequence analysisAdd BLAST21
Topological domaini487 – 498CytoplasmicSequence analysisAdd BLAST12
Transmembranei499 – 519Helical; Name=S3 of repeat IISequence analysisAdd BLAST21
Topological domaini520 – 528VacuolarSequence analysis9
Transmembranei529 – 546Helical; Voltage-sensor; Name=S4 of repeat IISequence analysisAdd BLAST18
Topological domaini547 – 557CytoplasmicSequence analysisAdd BLAST11
Transmembranei558 – 578Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini579 – 615VacuolarSequence analysisAdd BLAST37
Intramembranei616 – 630Pore-forming; Name=Pore-forming 2Add BLAST15
Topological domaini631 – 651VacuolarSequence analysisAdd BLAST21
Transmembranei652 – 672Helical; Name=S6 of repeat IISequence analysisAdd BLAST21
Topological domaini673 – 733CytoplasmicSequence analysisAdd BLAST61

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Plants display an impairment of both the Ca2+ inhibition of stomatal guard cell opening and abscisic acid (ABA) inhibition of seed germination.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi454D → N in fou2; shows elevated LOX and AOS activity levels and an increased resistance to B.cinerea. Strongly increases oxylipin biogenesis in response to wounding. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003431691 – 733Two pore calcium channel protein 1Add BLAST733

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q94KI8

PRoteomics IDEntifications database

More...
PRIDEi
Q94KI8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q94KI8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q94KI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q94KI8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q94KI8 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1552909,EBI-1552909

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
10969, 8 interactors

Database of interacting proteins

More...
DIPi
DIP-39873N

Protein interaction database and analysis system

More...
IntActi
Q94KI8, 9 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT4G03560.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1733
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q94KI8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini322 – 357EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini363 – 398EF-hand 2PROSITE-ProRule annotationAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INF7 Eukaryota
ENOG410XZT8 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000029959

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q94KI8

KEGG Orthology (KO)

More...
KOi
K16900

Identification of Orthologs from Complete Genome Data

More...
OMAi
RQTSHMR

Database of Orthologous Groups

More...
OrthoDBi
761764at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q94KI8

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051 EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR005821 Ion_trans_dom
IPR027359 Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q94KI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDPLIGRDS LGGGGTDRVR RSEAITHGTP FQKAAALVDL AEDGIGLPVE
60 70 80 90 100
ILDQSSFGES ARYYFIFTRL DLIWSLNYFA LLFLNFFEQP LWCEKNPKPS
110 120 130 140 150
CKDRDYYYLG ELPYLTNAES IIYEVITLAI LLVHTFFPIS YEGSRIFWTS
160 170 180 190 200
RLNLVKVACV VILFVDVLVD FLYLSPLAFD FLPFRIAPYV RVIIFILSIR
210 220 230 240 250
ELRDTLVLLS GMLGTYLNIL ALWMLFLLFA SWIAFVMFED TQQGLTVFTS
260 270 280 290 300
YGATLYQMFI LFTTSNNPDV WIPAYKSSRW SSVFFVLYVL IGVYFVTNLI
310 320 330 340 350
LAVVYDSFKE QLAKQVSGMD QMKRRMLEKA FGLIDSDKNG EIDKNQCIKL
360 370 380 390 400
FEQLTNYRTL PKISKEEFGL IFDELDDTRD FKINKDEFAD LCQAIALRFQ
410 420 430 440 450
KEEVPSLFEH FPQIYHSALS QQLRAFVRSP NFGYAISFIL IINFIAVVVE
460 470 480 490 500
TTLDIEESSA QKPWQVAEFV FGWIYVLEMA LKIYTYGFEN YWREGANRFD
510 520 530 540 550
FLVTWVIVIG ETATFITPDE NTFFSNGEWI RYLLLARMLR LIRLLMNVQR
560 570 580 590 600
YRAFIATFIT LIPSLMPYLG TIFCVLCIYC SIGVQVFGGL VNAGNKKLFE
610 620 630 640 650
TELAEDDYLL FNFNDYPNGM VTLFNLLVMG NWQVWMESYK DLTGTWWSIT
660 670 680 690 700
YFVSFYVITI LLLLNLVVAF VLEAFFTELD LEEEEKCQGQ DSQEKRNRRR
710 720 730
SAGSKSRSQR VDTLLHHMLG DELSKPECST SDT
Length:733
Mass (Da):84,873
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1CA978D6B8BFF445
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD11598 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAD15312 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB77841 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33K → R in BAB55460 (PubMed:11577183).Curated1
Sequence conflicti256Y → F in BAB55460 (PubMed:11577183).Curated1
Sequence conflicti612N → T in BAB55460 (PubMed:11577183).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB053952 mRNA Translation: BAB55460.1
AF360372 mRNA Translation: AAK39554.1
AC005142 Genomic DNA Translation: AAD15312.1 Sequence problems.
AF071527 Genomic DNA Translation: AAD11598.1 Sequence problems.
AL161497 Genomic DNA Translation: CAB77841.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE82337.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B85045

NCBI Reference Sequences

More...
RefSeqi
NP_567258.1, NM_116594.5

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G03560.1; AT4G03560.1; AT4G03560

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
825655

Gramene; a comparative resource for plants

More...
Gramenei
AT4G03560.1; AT4G03560.1; AT4G03560

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G03560

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053952 mRNA Translation: BAB55460.1
AF360372 mRNA Translation: AAK39554.1
AC005142 Genomic DNA Translation: AAD15312.1 Sequence problems.
AF071527 Genomic DNA Translation: AAD11598.1 Sequence problems.
AL161497 Genomic DNA Translation: CAB77841.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE82337.1
PIRiB85045
RefSeqiNP_567258.1, NM_116594.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DQQX-ray2.87A12-733[»]
5E1JX-ray3.31A1-733[»]
5TUAX-ray3.30A1-733[»]
6CX0X-ray3.50A11-733[»]
6E1Kelectron microscopy3.30A/B11-733[»]
6E1Melectron microscopy3.30A/B11-733[»]
6E1Pelectron microscopy3.70A/B11-733[»]
SMRiQ94KI8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi10969, 8 interactors
DIPiDIP-39873N
IntActiQ94KI8, 9 interactors
STRINGi3702.AT4G03560.1

Protein family/group databases

TCDBi1.A.1.11.26 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiQ94KI8
SwissPalmiQ94KI8

Proteomic databases

PaxDbiQ94KI8
PRIDEiQ94KI8

Genome annotation databases

EnsemblPlantsiAT4G03560.1; AT4G03560.1; AT4G03560
GeneIDi825655
GrameneiAT4G03560.1; AT4G03560.1; AT4G03560
KEGGiath:AT4G03560

Organism-specific databases

AraportiAT4G03560
TAIRilocus:2128716 AT4G03560

Phylogenomic databases

eggNOGiENOG410INF7 Eukaryota
ENOG410XZT8 LUCA
HOGENOMiHOG000029959
InParanoidiQ94KI8
KOiK16900
OMAiRQTSHMR
OrthoDBi761764at2759
PhylomeDBiQ94KI8

Miscellaneous databases

Protein Ontology

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PROi
PR:Q94KI8

Gene expression databases

ExpressionAtlasiQ94KI8 baseline and differential
GenevisibleiQ94KI8 AT

Family and domain databases

CDDicd00051 EFh, 1 hit
Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR005821 Ion_trans_dom
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPC1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94KI8
Secondary accession number(s): Q948T1, Q9ZT83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: December 1, 2001
Last modified: September 18, 2019
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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