Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 92 (16 Oct 2019)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Vacuolar protein sorting-associated protein 52 A

Gene

VPS52

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (By similarity). Required for pollen tube elongation and other polar growth.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 52 A
Short name:
AtVPS52
Alternative name(s):
ARE1-like protein POK
Protein POKY POLLEN TUBE
Protein T-DNA TRANSMISSION DEFECT 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VPS52
Synonyms:POK, TTD8
Ordered Locus Names:At1g71270
ORF Names:F3I17.8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G71270

The Arabidopsis Information Resource

More...
TAIRi
locus:2032343 AT1G71270

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Lethal when homozygous. In hemizygous plants, male gametophytic mutants characterized by very short pollen tubes. Male-specific transmission defect.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004248431 – 707Vacuolar protein sorting-associated protein 52 AAdd BLAST707

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q94KD3

PRoteomics IDEntifications database

More...
PRIDEi
Q94KD3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mostly expressed in roots and flower buds, and, at low levels, in seeds, whole inflorescence and mature flowers. Also detected in pollen. Present in pollen, buds, leaves, and roots (at protein level).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In seedlings, expressed in the root apex, mostly in the elongation zone and emerging lateral root primordia, in very young leaves and stipules. In flowers, detected from the earliest stages of flower development, before meiosis and gametogenesis and maintained later. As flower bud size reaches 1.6 to 1.7 mm, confined to male gametophytic tissues and female sporophytic tissues, including ovules. At maturity, accumulates in pollen grains within the anthers. At later postpollination stages, expressed in developing seeds. Accumulates in intracellular compartments in both sporophytic and gametophytic tissues (at protein level).2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q94KD3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q94KD3 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Golgi-associated retrograde protein (GARP) complex, composed by VPS52, VPS53 and VPS54.

Interacts directly with VPS53. Binds to VPS51 (PubMed:24757006).

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
28688, 4 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G71270.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q94KD3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili181 – 203Sequence analysisAdd BLAST23

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS52 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1961 Eukaryota
ENOG410XNZ1 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000020960

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q94KD3

KEGG Orthology (KO)

More...
KOi
K20298

Identification of Orthologs from Complete Genome Data

More...
OMAi
RQYSRQI

Database of Orthologous Groups

More...
OrthoDBi
158568at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q94KD3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007258 Vps52

The PANTHER Classification System

More...
PANTHERi
PTHR14190 PTHR14190, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04129 Vps52, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q94KD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDISIDALG QTMGDFSNHE KLGFDLGAFV GDLAFEEDSG SEDISLEGLQ
60 70 80 90 100
QELEECESDE VVANILSSGD KLREYAKGVE NNLRKVELDS IEDYIKESDN
110 120 130 140 150
LVSLHDQIRD CDSILSQMET LLSGFQEEIG SISSDIKILQ EKSMDMGLRL
160 170 180 190 200
KNRRVAESKL AKFVEDIIVP PKMIDVIVDG EVNEEYMKTL EILSKKLKFV
210 220 230 240 250
EADQAVKSSK ALKDVEPELE KLRQKAISKV YDFIVQKLIA LRKPKTNIQI
260 270 280 290 300
LQQSVLLKYK YIISFLKEHG KEVFMDVRAA YIDTMNKVLS AHFRAYIQAL
310 320 330 340 350
EKLQLDIATA YDLIGVETRT TGLFSRAREP LKNRSAVFAL GDRIKIIKDI
360 370 380 390 400
DQPALIPHIA EASSLKYPYE VLFRSLHKLL MDTATSEYMF CDDFFGEESI
410 420 430 440 450
FYEIFAGPFS VIDEHFNPVL SNCFDAIGLM LMIRIIHHHQ LIMSRRRIPC
460 470 480 490 500
LDSYLDKVNI SLWPRFKMVF DSHLSSLRDA NIKTLWEDDV HPHYVMRRYA
510 520 530 540 550
EFTASFIHLN VEYGDGQLDI NLERLRMAVD GLILKLAKLF PRPKQQIVFL
560 570 580 590 600
INNYDMTIAV LKEAGPEGGK IQMHFEEMLK SNTSLFVEEL LVEHFSDLIK
610 620 630 640 650
FVKNRASEDS SLNPERSITI AEVEPLVKDF GSRWKTAIEL MDKDIITSFS
660 670 680 690 700
NFLCGMDILR AALTQLLLYY TRLTDCIKKI DGGSALNRDL VSIQSIMYEI

RKYSKTF
Length:707
Mass (Da):80,938
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i030C26D60A9A2E9F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG51892 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAD94582 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti179D → G in DAA01355 (PubMed:15235115).Curated1
Sequence conflicti583T → P in DAA01355 (PubMed:15235115).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BK000522 mRNA Translation: DAA01355.1
AC016162 Genomic DNA Translation: AAG51892.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE35182.1
AF367286 mRNA Translation: AAK56274.1
BT004525 mRNA Translation: AAO42771.1
AK221995 mRNA Translation: BAD94582.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...
PIRi
D96737

NCBI Reference Sequences

More...
RefSeqi
NP_565015.1, NM_105796.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G71270.1; AT1G71270.1; AT1G71270

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
843468

Gramene; a comparative resource for plants

More...
Gramenei
AT1G71270.1; AT1G71270.1; AT1G71270

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G71270

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK000522 mRNA Translation: DAA01355.1
AC016162 Genomic DNA Translation: AAG51892.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE35182.1
AF367286 mRNA Translation: AAK56274.1
BT004525 mRNA Translation: AAO42771.1
AK221995 mRNA Translation: BAD94582.1 Different initiation.
PIRiD96737
RefSeqiNP_565015.1, NM_105796.3

3D structure databases

SMRiQ94KD3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi28688, 4 interactors
STRINGi3702.AT1G71270.1

Proteomic databases

PaxDbiQ94KD3
PRIDEiQ94KD3

Genome annotation databases

EnsemblPlantsiAT1G71270.1; AT1G71270.1; AT1G71270
GeneIDi843468
GrameneiAT1G71270.1; AT1G71270.1; AT1G71270
KEGGiath:AT1G71270

Organism-specific databases

AraportiAT1G71270
TAIRilocus:2032343 AT1G71270

Phylogenomic databases

eggNOGiKOG1961 Eukaryota
ENOG410XNZ1 LUCA
HOGENOMiHOG000020960
InParanoidiQ94KD3
KOiK20298
OMAiRQYSRQI
OrthoDBi158568at2759
PhylomeDBiQ94KD3

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q94KD3

Gene expression databases

ExpressionAtlasiQ94KD3 baseline and differential
GenevisibleiQ94KD3 AT

Family and domain databases

InterProiView protein in InterPro
IPR007258 Vps52
PANTHERiPTHR14190 PTHR14190, 1 hit
PfamiView protein in Pfam
PF04129 Vps52, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVP52A_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94KD3
Secondary accession number(s): Q56WP0, Q68EC6, Q9FVV3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: December 1, 2001
Last modified: October 16, 2019
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again