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Entry version 94 (17 Jun 2020)
Sequence version 1 (01 Dec 2001)
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Protein

MLO-like protein 14

Gene

MLO14

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in modulation of pathogen defense and leaf cell death. Activity seems to be regulated by Ca2+-dependent calmodulin binding and seems not to require heterotrimeric G proteins (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Pathogenesis-related protein
Biological processPlant defense

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MLO-like protein 14
Short name:
AtMlo14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MLO14
Ordered Locus Names:At1g26700
ORF Names:T24P13.8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G26700

The Arabidopsis Information Resource

More...
TAIRi
locus:2200640 AT1G26700

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13ExtracellularSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini35 – 63CytoplasmicSequence analysisAdd BLAST29
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 158ExtracellularSequence analysisAdd BLAST74
Transmembranei159 – 179Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini180 – 281CytoplasmicSequence analysisAdd BLAST102
Transmembranei282 – 302Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini303ExtracellularSequence analysis1
Transmembranei304 – 324Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini325 – 366CytoplasmicSequence analysisAdd BLAST42
Transmembranei367 – 387Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini388 – 406ExtracellularSequence analysisAdd BLAST19
Transmembranei407 – 427Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini428 – 554CytoplasmicSequence analysisAdd BLAST127

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002099441 – 554MLO-like protein 14Add BLAST554

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q94KB1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
238359

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q94KB1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q94KB1 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
24447, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q94KB1, 8 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G26700.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni441 – 462Calmodulin-bindingAdd BLAST22

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminus contains a calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MLO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK25 Eukaryota
ENOG410XR5S LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024720_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q94KB1

KEGG Orthology (KO)

More...
KOi
K08472

Identification of Orthologs from Complete Genome Data

More...
OMAi
IWEDEVH

Database of Orthologous Groups

More...
OrthoDBi
448417at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q94KB1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004326 Mlo

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03094 Mlo, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q94KB1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MREETEPSER TLGLTPTWSV ATVLTIFVFV SLIVERSIHR LSNWLQKTKR
60 70 80 90 100
KPLFAALEKM KEELMLLGFI SLLLTATSST IANICVSSSF HNDRFVPCTP
110 120 130 140 150
SEINEELEST ISTVKRTQLT RSLFLHTLRR RLSGIGEDTC SEGHEPFLSY
160 170 180 190 200
EGMEQLHRFI FIMAVTHVTY SCLTMLLAIV KIHRWRIWED EVHMDRNDCL
210 220 230 240 250
TVVAREKIFR RQTTFVQYHT SAPLVKNRLL IWVICFFRQF GHSVVRSDYL
260 270 280 290 300
TLRKGFIMNH HLTLTYDFHS YMIRSMEEEF QKIVGVSGPL WGFVVGFMLF
310 320 330 340 350
NIKGSNLYFW LAIIPITLVL LVGAKLQHVI ATLALENASI TEYASGIKLR
360 370 380 390 400
PRDELFWFKK PELLLSLIHF IQFQNAFELA SFFWFWWQFG YNSCFLRNHL
410 420 430 440 450
LVYLRLILGF SGQFLCSYST LPLYALVTQM GTNYKAALLP QRVRETINGW
460 470 480 490 500
GKATRRKRRH GLYGDDSTIR TETSTIASVD EYNDQVLDVS ETSPVQDNEL
510 520 530 540 550
ELQLIRGACG NSSSVETPIL RPCASISSTT FSRLQTETTD SLSRSSSLPM

RREC
Length:554
Mass (Da):63,923
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CA658B8EA6EF3D2
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF87028 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF369575 mRNA Translation: AAK53807.1
AC006535 Genomic DNA Translation: AAF87028.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE30722.1
CP002684 Genomic DNA Translation: ANM57918.1

Protein sequence database of the Protein Information Resource

More...
PIRi
H86393

NCBI Reference Sequences

More...
RefSeqi
NP_001319086.1, NM_001332726.1
NP_564257.1, NM_102433.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G26700.1; AT1G26700.1; AT1G26700
AT1G26700.2; AT1G26700.2; AT1G26700

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
839211

Gramene; a comparative resource for plants

More...
Gramenei
AT1G26700.1; AT1G26700.1; AT1G26700
AT1G26700.2; AT1G26700.2; AT1G26700

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G26700

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF369575 mRNA Translation: AAK53807.1
AC006535 Genomic DNA Translation: AAF87028.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE30722.1
CP002684 Genomic DNA Translation: ANM57918.1
PIRiH86393
RefSeqiNP_001319086.1, NM_001332726.1
NP_564257.1, NM_102433.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi24447, 8 interactors
IntActiQ94KB1, 8 interactors
STRINGi3702.AT1G26700.1

Proteomic databases

PaxDbiQ94KB1
ProteomicsDBi238359

Genome annotation databases

EnsemblPlantsiAT1G26700.1; AT1G26700.1; AT1G26700
AT1G26700.2; AT1G26700.2; AT1G26700
GeneIDi839211
GrameneiAT1G26700.1; AT1G26700.1; AT1G26700
AT1G26700.2; AT1G26700.2; AT1G26700
KEGGiath:AT1G26700

Organism-specific databases

AraportiAT1G26700
TAIRilocus:2200640 AT1G26700

Phylogenomic databases

eggNOGiENOG410IK25 Eukaryota
ENOG410XR5S LUCA
HOGENOMiCLU_024720_2_1_1
InParanoidiQ94KB1
KOiK08472
OMAiIWEDEVH
OrthoDBi448417at2759
PhylomeDBiQ94KB1

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q94KB1

Gene expression databases

ExpressionAtlasiQ94KB1 baseline and differential
GenevisibleiQ94KB1 AT

Family and domain databases

InterProiView protein in InterPro
IPR004326 Mlo
PfamiView protein in Pfam
PF03094 Mlo, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLO14_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94KB1
Secondary accession number(s): Q9LQY2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: December 1, 2001
Last modified: June 17, 2020
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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