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Protein

Cytochrome P450 90D2

Gene

CYP90D2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May convert 6-deoxoteasterone to 3-dehydro-6-deoxoteasterone, and teasterone to 3-dehydroteasterone. Catalyzes the C6-oxidation step in brassinosteroids biosynthesis. Involved in the elongation of leaf sheaths and stems.1 Publication

Cofactori

hemeBy similarity

Pathwayi: brassinosteroid biosynthesis

This protein is involved in the pathway brassinosteroid biosynthesis, which is part of Plant hormone biosynthesis.
View all proteins of this organism that are known to be involved in the pathway brassinosteroid biosynthesis and in Plant hormone biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi437Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processBrassinosteroid biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-OSA-211916 Vitamins
R-OSA-5365859 RA biosynthesis pathway
UniPathwayiUPA00381

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 90D2 (EC:1.14.-.-)
Alternative name(s):
C6-oxidase
Gene namesi
Name:CYP90D2
Synonyms:D2
Ordered Locus Names:Os01g0197100, LOC_Os01g10040
ORF Names:P0419B01.11
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Plants show abnormalities in growth: inhibition of second internode elongation, shortened leaf sheaths, erect leaves, and deficiency in skotomorphogenesis. Treatment with exogenous brassinolide rescues the abnormal phenotype.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi305P → S in d2-2; dwarf and defective in brassinosteroid biosynthesis. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000521871 – 490Cytochrome P450 90D2Add BLAST490

Proteomic databases

PaxDbiQ94IW5
PRIDEiQ94IW5

Expressioni

Tissue specificityi

Expressed at low levels leaf blades, shoot apex and elongating stem.1 Publication

Inductioni

Down-regulated by brassinolide in ebisu dwarf (d2) mutant.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g10040.1

Structurei

3D structure databases

ProteinModelPortaliQ94IW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
HOGENOMiHOG000237614
InParanoidiQ94IW5
KOiK09589
OMAiDEPYRFN
OrthoDBiEOG09360A4G

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q94IW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSAAAGWAA PAFAVAAVVI WVVLCSELLR RRRRGAGSGK GDAAAAARLP
60 70 80 90 100
PGSFGWPVVG ETLEFVSCAY SPRPEAFVDK RRKLHGSAVF RSHLFGSATV
110 120 130 140 150
VTADAEVSRF VLQSDARAFV PWYPRSLTEL MGKSSILLIN GALQRRVHGL
160 170 180 190 200
VGAFFKSSHL KSQLTADMRR RLSPALSSFP DSSLLHVQHL AKSVVFEILV
210 220 230 240 250
RGLIGLEAGE EMQQLKQQFQ EFIVGLMSLP IKLPGTRLYR SLQAKKKMAR
260 270 280 290 300
LIQRIIREKR ARRAAASPPR DAIDVLIGDG SDELTDELIS DNMIDLMIPA
310 320 330 340 350
EDSVPVLITL AVKFLSECPL ALHQLEEENI QLKRRKTDMG ETLQWTDYMS
360 370 380 390 400
LSFTQHVITE TLRLGNIIGG IMRKAVRDVE VKGHLIPKGW CVFVYFRSVH
410 420 430 440 450
LDDTLYDEPY KFNPWRWKEK DMSNGSFTPF GGGQRLCPGL DLARLEASIF
460 470 480 490
LHHLVTSFRW VAEEDHIVNF PTVRLKRGMP IRVTAKEDDD
Length:490
Mass (Da):54,825
Last modified:December 1, 2001 - v1
Checksum:i9EC2853BBAFBB88F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003244 Genomic DNA Translation: BAB56089.1
AP008207 Genomic DNA Translation: BAF04211.1
AP014957 Genomic DNA Translation: BAS70868.1
RefSeqiXP_015611433.1, XM_015755947.1

Genome annotation databases

EnsemblPlantsiOs01t0197100-01; Os01t0197100-01; Os01g0197100
GeneIDi4327329
GrameneiOs01t0197100-01; Os01t0197100-01; Os01g0197100
KEGGiosa:4327329

Similar proteinsi

Entry informationi

Entry nameiC90D2_ORYSJ
AccessioniPrimary (citable) accession number: Q94IW5
Secondary accession number(s): Q0JPW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

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