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Entry version 110 (08 May 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Pyruvate dehydrogenase [NADP(+)], mitochondrial

Gene

PNO

Organism
Euglena gracilis
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pyruvate dehydrogenase [NADP+] is one of three enzymes participating in respiratory metabolism. The enzyme is also active with 2-oxobutyrate and oxaloacetate. The enzyme is oxygen sensitive.2 Publications

Miscellaneous

Arose from gene fusion of pyruvate:ferredoxin oxidoreductase and cytochrome-P450 reductase. Gene fusion has only been found in Euglena and Cryptosporidium.2 Publications
Euglena cells absolutely require thiamine for growth due to the lack of a pyrimidine formation biosynthetic pathway. Thiamine is actively taken up into the cells and is used as a cofactor after being converted to TPP (thiamine pyrophosphate).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=210 µM for pyruvate1 Publication
  2. KM=8 µM for CoA1 Publication
  3. KM=30 µM for NADP+1 Publication

    pH dependencei

    Optimum pH is 7.5.1 Publication

    Temperature dependencei

    Optimum temperature is 40 degrees Celsius.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi756Iron-sulfur 1 (4Fe-4S)Sequence analysis1
    Metal bindingi759Iron-sulfur 1 (4Fe-4S)Sequence analysis1
    Metal bindingi762Iron-sulfur 1 (4Fe-4S)Sequence analysis1
    Metal bindingi766Iron-sulfur 1 (4Fe-4S)Sequence analysis1
    Metal bindingi811Iron-sulfur 2 (4Fe-4S)Sequence analysis1
    Metal bindingi814Iron-sulfur 2 (4Fe-4S)Sequence analysis1
    Metal bindingi817Iron-sulfur 2 (4Fe-4S)Sequence analysis1
    Metal bindingi821Iron-sulfur 2 (4Fe-4S)Sequence analysis1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1458 – 1469FADBy similarityAdd BLAST12
    Nucleotide bindingi1585 – 1595FADBy similarityAdd BLAST11

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processElectron transport, Transport
    Ligand4Fe-4S, FAD, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NADP, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:MONOMER-17049

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.2.1.51 2197

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q94IN5

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Pyruvate dehydrogenase [NADP(+)], mitochondrial (EC:1.2.1.511 Publication)
    Alternative name(s):
    Aquacobalamin reductase [NADPH]
    EgPNOmt
    Pyruvate:NADP(+) oxidoreductase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PNO
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEuglena gracilisImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3039 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaEuglenozoaEuglenidaEuglenalesEuglenaceaeEuglena

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    GO - Cellular componenti

    Keywords - Cellular componenti

    Mitochondrion

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 37Mitochondrion1 PublicationAdd BLAST37
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002386738 – 1803Pyruvate dehydrogenase [NADP(+)], mitochondrialAdd BLAST1766

    Proteomic databases

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q94IN5

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Expressed in both aerobic and anaerobic conditions.

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.2 Publications

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q94IN5

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini747 – 7764Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST30
    Domaini802 – 8314Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30
    Domaini1248 – 1391Flavodoxin-likePROSITE-ProRule annotationAdd BLAST144
    Domaini1425 – 1650FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST226

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    In the N-terminal section; belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.Curated

    Keywords - Domaini

    Repeat, Transit peptide

    Phylogenomic databases

    KEGG Orthology (KO)

    More...
    KOi
    K21682

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.20.990.10, 1 hit
    3.40.50.360, 1 hit
    3.40.50.80, 1 hit
    3.40.50.920, 1 hit
    3.40.920.10, 1 hit
    4.10.780.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR017896 4Fe4S_Fe-S-bd
    IPR017900 4Fe4S_Fe_S_CS
    IPR003097 CysJ-like_FAD-binding
    IPR017927 FAD-bd_FR_type
    IPR001094 Flavdoxin-like
    IPR008254 Flavodoxin/NO_synth
    IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
    IPR029039 Flavoprotein-like_sf
    IPR039261 FNR_nucleotide-bd
    IPR023173 NADPH_Cyt_P450_Rdtase_alpha
    IPR001433 OxRdtase_FAD/NAD-bd
    IPR033412 PFOR_II
    IPR037112 Pyrv-flavodox_OxR_EKR_sf
    IPR019456 Pyrv-flavodox_OxRtase_EKR
    IPR019752 Pyrv/ketoisovalerate_OxRed_cat
    IPR002880 Pyrv_Fd/Flavodoxin_OxRdtase_N
    IPR011895 Pyrv_flavodox_OxRed
    IPR002869 Pyrv_flavodox_OxRed_cen
    IPR017938 Riboflavin_synthase-like_b-brl
    IPR029061 THDP-binding
    IPR011766 TPP_enzyme-bd_C
    IPR009014 Transketo_C/PFOR_II

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF10371 EKR, 1 hit
    PF00667 FAD_binding_1, 1 hit
    PF12838 Fer4_7, 1 hit
    PF00258 Flavodoxin_1, 1 hit
    PF00175 NAD_binding_1, 1 hit
    PF17147 PFOR_II, 1 hit
    PF01558 POR, 1 hit
    PF01855 POR_N, 1 hit
    PF02775 TPP_enzyme_C, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00369 FLAVODOXIN
    PR00371 FPNCR

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00890 EKR, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52218 SSF52218, 1 hit
    SSF52343 SSF52343, 1 hit
    SSF52518 SSF52518, 2 hits
    SSF52922 SSF52922, 1 hit
    SSF53323 SSF53323, 1 hit
    SSF63380 SSF63380, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR02176 pyruv_ox_red, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00198 4FE4S_FER_1, 2 hits
    PS51379 4FE4S_FER_2, 2 hits
    PS51384 FAD_FR, 1 hit
    PS50902 FLAVODOXIN_LIKE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    Q94IN5-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKQSVRPIIS NVLRKEVALY STIIGQDKGK EPTGRTYTSG PKPASHIEVP
    60 70 80 90 100
    HHVTVPATDR TPNPDAQFFQ SVDGSQATSH VAYALSDTAF IYPITPSSVM
    110 120 130 140 150
    GELADVWMAQ GRKNAFGQVV DVREMQSEAG AAGALHGALA AGAIATTFTA
    160 170 180 190 200
    SQGLLLMIPN MYKIAGELMP SVIHVAAREL AGHALSIFGG HADVMAVRQT
    210 220 230 240 250
    GWAMLCSHTV QQSHDMALIS HVATLKSSIP FVHFFDGFRT SHEVNKIKML
    260 270 280 290 300
    PYAELKKLVP PGTMEQHWAR SLNPMHPTIR GTNQSADIYF QNMESANQYY
    310 320 330 340 350
    TDLAEVVQET MDEVAPYIGR HYKIFEYVGA PDAEEVTVLM GSGATTVNEA
    360 370 380 390 400
    VDLLVKRGKK VGAVLVHLYR PWSTKAFEKV LPKTVKRIAA LDRCKEVTAL
    410 420 430 440 450
    GEPLYLDVSA TLNLFPERQN VKVIGGRYGL GSKDFIPEHA LAIYANLASE
    460 470 480 490 500
    NPIQRFTVGI TDDVTGTSVP FVNERVDTLP EGTRQCVFWG IGSDGTVGAN
    510 520 530 540 550
    RSAVRIIGDN SDLMVQAYFQ FDAFKSGGVT SSHLRFGPKP ITAQYLVTNA
    560 570 580 590 600
    DYIACHFQEY VKRFDMLDAI REGGTFVLNS RWTTEDMEKE IPADFRRNVA
    610 620 630 640 650
    QKKVRFYNVD ARKICDSFGL GKRINMLMQA CFFKLSGVLP LAEAQRLLNE
    660 670 680 690 700
    SIVHEYGKKG GKVVEMNQAV VNAVFAGDLP QEVQVPAAWA NAVDTSTRTP
    710 720 730 740 750
    TGIEFVDKIM RPLMDFKGDQ LPVSVMTPGG TFPVGTTQYA KRAIAAFIPQ
    760 770 780 790 800
    WIPANCTQCN YCSYVCPHAT IRPFVLTDQE VQLAPESFVT RKAKGDYQGM
    810 820 830 840 850
    NFRIQVAPED CTGCQVCVET CPDDALEMTD AFTATPVQRT NWEFAIKVPN
    860 870 880 890 900
    RGTMTDRYSL KGSQFQQPLL EFSGACEGCG ETPYVKLLTQ LFGERTVIAN
    910 920 930 940 950
    ATGCSSIWGG TAGLAPYTTN AKGQGPAWGN SLFEDNAEFG FGIAVANAQK
    960 970 980 990 1000
    RSRVRDCILQ AVEKKVADEG LTTLLAQWLQ DWNTGDKTLK YQDQIIAGLA
    1010 1020 1030 1040 1050
    QQRSKDPLLE QIYGMKDMLP NISQWIIGGD GWANDIGFGG LDHVLASGQN
    1060 1070 1080 1090 1100
    LNVLVLDTEM YSNTGGQASK STHMASVAKF ALGGKRTNKK NLTEMAMSYG
    1110 1120 1130 1140 1150
    NVYVATVSHG NMAQCVKAFV EAESYDGPSL IVGYAPCIEH GLRAGMARMV
    1160 1170 1180 1190 1200
    QESEAAIATG YWPLYRFDPR LATEGKNPFQ LDSKRIKGNL QEYLDRQNRY
    1210 1220 1230 1240 1250
    VNLKKNNPKG ADLLKSQMAD NITARFNRYR RMLEGPNTKA AAPSGNHVTI
    1260 1270 1280 1290 1300
    LYGSETGNSE GLAKELATDF ERREYSVAVQ ALDDIDVADL ENMGFVVIAV
    1310 1320 1330 1340 1350
    STCGQGQFPR NSQLFWRELQ RDKPEGWLKN LKYTVFGLGD STYYFYCHTA
    1360 1370 1380 1390 1400
    KQIDARLAAL GAQRVVPIGF GDDGDEDMFH TGFNNWIPSV WNELKTKTPE
    1410 1420 1430 1440 1450
    EALFTPSIAV QLTPNATPQD FHFAKSTPVL SITGAERITP ADHTRNFVTI
    1460 1470 1480 1490 1500
    RWKTDLSYQV GDSLGVFPEN TRSVVEEFLQ YYGLNPKDVI TIENKGSREL
    1510 1520 1530 1540 1550
    PHCMAVGDLF TKVLDILGKP NNRFYKTLSY FAVDKAEKER LLKIAEMGPE
    1560 1570 1580 1590 1600
    YSNILSEMYH YADIFHMFPS ARPTLQYLIE MIPNIKPRYY SISSAPIHTP
    1610 1620 1630 1640 1650
    GEVHSLVLID TWITLSGKHR TGLTCTMLEH LQAGQVVDGC IHPTAMEFPD
    1660 1670 1680 1690 1700
    HEKPVVMCAM GSGLAPFVAF LRERSTLRKQ GKKTGNMALY FGNRYEKTEF
    1710 1720 1730 1740 1750
    LMKEELKGHI NDGLLTLRCA FSRDDPKKKV YVQDLIKMDE KMMYDYLVVQ
    1760 1770 1780 1790 1800
    KGSMYCCGSR SFIKPVQESL KHCFMKAGGL TAEQAENEVI DMFTTGRYNI

    EAW
    Length:1,803
    Mass (Da):199,821
    Last modified:December 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AFB6E3869CADCC6
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50P → S AA sequence (PubMed:1910287).Curated1
    Sequence conflicti52H → A AA sequence (PubMed:1910287).Curated1
    Sequence conflicti53V → K AA sequence (PubMed:1910287).Curated1
    Sequence conflicti598 – 599NV → KL in BAB12024 (PubMed:11023353).Curated2
    Sequence conflicti1256T → E AA sequence (PubMed:1910287).Curated1
    Sequence conflicti1558M → T in BAB12024 (PubMed:11023353).Curated1
    Sequence conflicti1673 – 1674ER → DG in BAB12024 (PubMed:11023353).Curated2

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB021127 mRNA Translation: BAB12024.1
    AJ278425 mRNA Translation: CAC37628.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S36876

    Genome annotation databases

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ag:BAB12024

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB021127 mRNA Translation: BAB12024.1
    AJ278425 mRNA Translation: CAC37628.1
    PIRiS36876

    3D structure databases

    SMRiQ94IN5
    ModBaseiSearch...
    MobiDBiSearch...

    Proteomic databases

    PRIDEiQ94IN5

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    KEGGiag:BAB12024

    Phylogenomic databases

    KOiK21682

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-17049
    BRENDAi1.2.1.51 2197
    SABIO-RKiQ94IN5

    Family and domain databases

    Gene3Di1.20.990.10, 1 hit
    3.40.50.360, 1 hit
    3.40.50.80, 1 hit
    3.40.50.920, 1 hit
    3.40.920.10, 1 hit
    4.10.780.10, 1 hit
    InterProiView protein in InterPro
    IPR017896 4Fe4S_Fe-S-bd
    IPR017900 4Fe4S_Fe_S_CS
    IPR003097 CysJ-like_FAD-binding
    IPR017927 FAD-bd_FR_type
    IPR001094 Flavdoxin-like
    IPR008254 Flavodoxin/NO_synth
    IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
    IPR029039 Flavoprotein-like_sf
    IPR039261 FNR_nucleotide-bd
    IPR023173 NADPH_Cyt_P450_Rdtase_alpha
    IPR001433 OxRdtase_FAD/NAD-bd
    IPR033412 PFOR_II
    IPR037112 Pyrv-flavodox_OxR_EKR_sf
    IPR019456 Pyrv-flavodox_OxRtase_EKR
    IPR019752 Pyrv/ketoisovalerate_OxRed_cat
    IPR002880 Pyrv_Fd/Flavodoxin_OxRdtase_N
    IPR011895 Pyrv_flavodox_OxRed
    IPR002869 Pyrv_flavodox_OxRed_cen
    IPR017938 Riboflavin_synthase-like_b-brl
    IPR029061 THDP-binding
    IPR011766 TPP_enzyme-bd_C
    IPR009014 Transketo_C/PFOR_II
    PfamiView protein in Pfam
    PF10371 EKR, 1 hit
    PF00667 FAD_binding_1, 1 hit
    PF12838 Fer4_7, 1 hit
    PF00258 Flavodoxin_1, 1 hit
    PF00175 NAD_binding_1, 1 hit
    PF17147 PFOR_II, 1 hit
    PF01558 POR, 1 hit
    PF01855 POR_N, 1 hit
    PF02775 TPP_enzyme_C, 1 hit
    PRINTSiPR00369 FLAVODOXIN
    PR00371 FPNCR
    SMARTiView protein in SMART
    SM00890 EKR, 1 hit
    SUPFAMiSSF52218 SSF52218, 1 hit
    SSF52343 SSF52343, 1 hit
    SSF52518 SSF52518, 2 hits
    SSF52922 SSF52922, 1 hit
    SSF53323 SSF53323, 1 hit
    SSF63380 SSF63380, 1 hit
    TIGRFAMsiTIGR02176 pyruv_ox_red, 1 hit
    PROSITEiView protein in PROSITE
    PS00198 4FE4S_FER_1, 2 hits
    PS51379 4FE4S_FER_2, 2 hits
    PS51384 FAD_FR, 1 hit
    PS50902 FLAVODOXIN_LIKE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPNO_EUGGR
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94IN5
    Secondary accession number(s): Q9FZP8
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: December 1, 2001
    Last modified: May 8, 2019
    This is version 110 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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