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Entry version 106 (16 Oct 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Protein NAR1

Gene

NAR1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery (PubMed:23104832). Required for the maturation of extramitochondrial Fe/S proteins (By similarity). Required for expression of the imprinted FWA gene, for seed development and is involved in the oxidative stress response in vegetative tissues (PubMed:23734982). Involved in the regulation of cell size, ploidy and cell cycle progression (PubMed:23639116). Required for growth under normoxic conditions and necessary for recovery after hypoxic treatment but its action is reactive oxygen species (ROS) independent (PubMed:23639116).By similarity3 Publications

Miscellaneous

Coordinates probably two (Fe-S) clusters with different magnetic properties (PubMed:18329103). Knockdown mutants have a dwarf phenotype, but are indistinguishable from wild type under hypoxic conditions (PubMed:18329103, PubMed:23639116).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi24Iron-sulfur 1 (4Fe-4S)Sequence analysis1
Metal bindingi61Iron-sulfur 1 (4Fe-4S)Sequence analysis1
Metal bindingi64Iron-sulfur 1 (4Fe-4S)Sequence analysis1
Metal bindingi67Iron-sulfur 1 (4Fe-4S)Sequence analysis1
Metal bindingi177Iron-sulfur 2 (4Fe-4S)Sequence analysis1
Metal bindingi233Iron-sulfur 2 (4Fe-4S)Sequence analysis1
Metal bindingi390Iron-sulfur 2 (4Fe-4S)Sequence analysis1
Metal bindingi394Iron-sulfur 2 (4Fe-4S)Sequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein NAR11 Publication
Alternative name(s):
Nuclear architecture related 11 Publication
Protein GROWTH AT DIFFERENT OXYGEN LEVELS INFLUENCES MORPHOGENESIS1 Publication
[FeFe]-hydrogenase-like protein GOLLUM1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NAR11 Publication
Synonyms:GOLLUM1 Publication
Ordered Locus Names:At4g16440Imported
ORF Names:dl4245cImported, FCAALL.367Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G16440

The Arabidopsis Information Resource

More...
TAIRi
locus:2130634 AT4G16440

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality when homozygous (PubMed:23104832, PubMed:23734982, PubMed:23639116).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi61C → A: No effect on UV-visible spectrum; when associated with A-64. 1 Publication1
Mutagenesisi64C → A: No effect on UV-visible spectrum; when associated with A-61. 1 Publication1
Mutagenesisi390C → A: Loss of (Fe-S) clusters coordination; when associated with A-394. 1 Publication1
Mutagenesisi394C → A: Loss of (Fe-S) clusters coordination; when associated with A-390. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004335181 – 474Protein NAR1Add BLAST474

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q94CL6

PRoteomics IDEntifications database

More...
PRIDEi
Q94CL6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in developing tissues, including shoot apex, young leaves, vascular tissues, root tips, pedicels, carpels and developing seeds.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout plant development.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q94CL6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q94CL6 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a complex composed of AE7, CIA1, MMS19 and NAR1.

Interacts with CIA1.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT4G16440.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q94CL6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NARF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2439 Eukaryota
COG4624 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000191744

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q94CL6

Identification of Orthologs from Complete Genome Data

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OMAi
FTWVVDT

Database of Orthologous Groups

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OrthoDBi
705416at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q94CL6

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009016 Fe_hydrogenase
IPR004108 Fe_hydrogenase_lsu_C
IPR003149 Fe_hydrogenase_ssu

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02906 Fe_hyd_lg_C, 1 hit
PF02256 Fe_hyd_SSU, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00902 Fe_hyd_SSU, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53920 SSF53920, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q94CL6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEKFSPTLR LGDLNDFIAP SQACVISLKD SKPIVKKSDR PQVVIAPKQQ
60 70 80 90 100
LEPVKISLKD CLACSGCITS AETVMLEKQS LDEFLSALSK GKDVVVSVSP
110 120 130 140 150
QSRASLAVHY DISPLQVFKK LTTFLKSLGV KAVFDTSCSR DLVLIESCNE
160 170 180 190 200
FVSRYKQANS DDGENSQSPL PVLSSACPGW ICYAEKQLGS YVLPYVSSVK
210 220 230 240 250
SPQQAIGAAI KHHLCQALGL RLHEVYHVTV MPCYDKKLEA ARDDFVFDDG
260 270 280 290 300
TQDNGDLKLT EVDSVLTTGE IMDLIKLKGV DFKDLEESPL DRVLTNVTEE
310 320 330 340 350
GDLYGVAGSS GGYAETIFRH AAKALFGQTI EGPLEFKTLR NSDFREVTLQ
360 370 380 390 400
LEGKTVLKFA LCYGFQNLQN IVRRVKTRKC DYQYVEIMAC PAGCLNGGGQ
410 420 430 440 450
IKPKTGQSQK ELIHSLEATY MNDTTLNTDP YQNPTAKRLF EEWLKEPGSN
460 470
EAKKYLHTQY HPVVKSVTSQ LNNW
Length:474
Mass (Da):52,504
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CF66FFF17D8CA55
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC42607 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAB10420 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At4g16440 has been split into 3 genes: At4g16440, At4g16442 and At4g16444.Curated
The sequence CAB78686 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At4g16440 has been split into 3 genes: At4g16440, At4g16442 and At4g16444.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ320258 Genomic DNA Translation: CAC44620.1
Z97341 Genomic DNA Translation: CAB10420.1 Sequence problems.
AL161544 Genomic DNA Translation: CAB78686.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE83748.1
AK117970 mRNA Translation: BAC42607.1 Different initiation.
BT008777 mRNA Translation: AAP68216.1

NCBI Reference Sequences

More...
RefSeqi
NP_567496.4, NM_117739.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G16440.1; AT4G16440.1; AT4G16440

Database of genes from NCBI RefSeq genomes

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GeneIDi
827338

Gramene; a comparative resource for plants

More...
Gramenei
AT4G16440.1; AT4G16440.1; AT4G16440

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G16440

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ320258 Genomic DNA Translation: CAC44620.1
Z97341 Genomic DNA Translation: CAB10420.1 Sequence problems.
AL161544 Genomic DNA Translation: CAB78686.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE83748.1
AK117970 mRNA Translation: BAC42607.1 Different initiation.
BT008777 mRNA Translation: AAP68216.1
RefSeqiNP_567496.4, NM_117739.4

3D structure databases

SMRiQ94CL6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G16440.1

Proteomic databases

PaxDbiQ94CL6
PRIDEiQ94CL6

Genome annotation databases

EnsemblPlantsiAT4G16440.1; AT4G16440.1; AT4G16440
GeneIDi827338
GrameneiAT4G16440.1; AT4G16440.1; AT4G16440
KEGGiath:AT4G16440

Organism-specific databases

AraportiAT4G16440
TAIRilocus:2130634 AT4G16440

Phylogenomic databases

eggNOGiKOG2439 Eukaryota
COG4624 LUCA
HOGENOMiHOG000191744
InParanoidiQ94CL6
OMAiFTWVVDT
OrthoDBi705416at2759
PhylomeDBiQ94CL6

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q94CL6

Gene expression databases

ExpressionAtlasiQ94CL6 baseline and differential
GenevisibleiQ94CL6 AT

Family and domain databases

InterProiView protein in InterPro
IPR009016 Fe_hydrogenase
IPR004108 Fe_hydrogenase_lsu_C
IPR003149 Fe_hydrogenase_ssu
PfamiView protein in Pfam
PF02906 Fe_hyd_lg_C, 1 hit
PF02256 Fe_hyd_SSU, 1 hit
SMARTiView protein in SMART
SM00902 Fe_hyd_SSU, 1 hit
SUPFAMiSSF53920 SSF53920, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAR1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94CL6
Secondary accession number(s): Q8GXY2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2015
Last sequence update: December 1, 2001
Last modified: October 16, 2019
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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