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Entry version 135 (16 Oct 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Beta carbonic anhydrase 5, chloroplastic

Gene

BCA5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Reversible hydration of carbon dioxide.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
LigandZinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta carbonic anhydrase 5, chloroplastic (EC:4.2.1.1)
Short name:
AtbCA5
Short name:
AtbetaCA5
Alternative name(s):
Beta carbonate dehydratase 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCA5
Ordered Locus Names:At4g33580
ORF Names:T16L1.70
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G33580

The Arabidopsis Information Resource

More...
TAIRi
locus:2134218 AT4G33580

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 56ChloroplastSequence analysisAdd BLAST56
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042973757 – 301Beta carbonic anhydrase 5, chloroplasticAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei65PhosphothreonineBy similarity1
Modified residuei128PhosphoserineBy similarity1
Modified residuei231S-nitrosocysteineBy similarity1

Keywords - PTMi

Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q94CE3

PRoteomics IDEntifications database

More...
PRIDEi
Q94CE3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q94CE3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in aerial tissues including leaves, stems, flowers and siliques.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q94CE3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q94CE3 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT4G33580.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q94CE3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1578 Eukaryota
COG0288 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000125183

KEGG Orthology (KO)

More...
KOi
K01673

Identification of Orthologs from Complete Genome Data

More...
OMAi
INCTFEK

Database of Orthologous Groups

More...
OrthoDBi
1136193at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q94CE3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1050.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001765 Carbonic_anhydrase
IPR015892 Carbonic_anhydrase_CS
IPR036874 Carbonic_anhydrase_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00484 Pro_CA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00947 Pro_CA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53056 SSF53056, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00704 PROK_CO2_ANHYDRASE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q94CE3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAATPTHFSV SHDPFSSTSL LNLQTQAIFG PNHSLKTTQL RIPASFRRKA
60 70 80 90 100
TNLQVMASGK TPGLTQEANG VAIDRQNNTD VFDDMKQRFL AFKKLKYMDD
110 120 130 140 150
FEHYKNLADA QAPKFLVIAC ADSRVCPSAV LGFQPGDAFT VRNIANLVPP
160 170 180 190 200
YESGPTETKA ALEFSVNTLN VENILVIGHS RCGGIQALMK MEDEGDSRSF
210 220 230 240 250
IHNWVVVGKK AKESTKAVAS NLHFDHQCQH CEKASINHSL ERLLGYPWIE
260 270 280 290 300
EKVRQGSLSL HGGYYNFVDC TFEKWTVDYA ASRGKKKEGS GIAVKDRSVW

S
Length:301
Mass (Da):33,401
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6CE4F5FEE2B38052
GO
Isoform 2 (identifier: Q94CE3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-98: M → IR

Show »
Length:302
Mass (Da):33,539
Checksum:i5B816E0CA3CAC607
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA20571 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB80075 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05507298M → IR in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL031394 Genomic DNA Translation: CAA20571.1 Sequence problems.
AL161583 Genomic DNA Translation: CAB80075.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE86248.1
CP002687 Genomic DNA Translation: AEE86249.1
CP002687 Genomic DNA Translation: ANM66692.1
AY034930 mRNA Translation: AAK59437.1
AY122986 mRNA Translation: AAM67519.1
AK221870 mRNA Translation: BAD94173.1
AY088420 mRNA Translation: AAM65957.1
AK317565 mRNA Translation: BAH20229.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T04975

NCBI Reference Sequences

More...
RefSeqi
NP_001031784.1, NM_001036707.1 [Q94CE3-2]
NP_001328574.1, NM_001342222.1 [Q94CE3-1]
NP_567928.1, NM_119514.4 [Q94CE3-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G33580.1; AT4G33580.1; AT4G33580 [Q94CE3-1]
AT4G33580.2; AT4G33580.2; AT4G33580 [Q94CE3-2]
AT4G33580.3; AT4G33580.3; AT4G33580 [Q94CE3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
829498

Gramene; a comparative resource for plants

More...
Gramenei
AT4G33580.1; AT4G33580.1; AT4G33580 [Q94CE3-1]
AT4G33580.2; AT4G33580.2; AT4G33580 [Q94CE3-2]
AT4G33580.3; AT4G33580.3; AT4G33580 [Q94CE3-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G33580

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031394 Genomic DNA Translation: CAA20571.1 Sequence problems.
AL161583 Genomic DNA Translation: CAB80075.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE86248.1
CP002687 Genomic DNA Translation: AEE86249.1
CP002687 Genomic DNA Translation: ANM66692.1
AY034930 mRNA Translation: AAK59437.1
AY122986 mRNA Translation: AAM67519.1
AK221870 mRNA Translation: BAD94173.1
AY088420 mRNA Translation: AAM65957.1
AK317565 mRNA Translation: BAH20229.1
PIRiT04975
RefSeqiNP_001031784.1, NM_001036707.1 [Q94CE3-2]
NP_001328574.1, NM_001342222.1 [Q94CE3-1]
NP_567928.1, NM_119514.4 [Q94CE3-1]

3D structure databases

SMRiQ94CE3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G33580.2

PTM databases

iPTMnetiQ94CE3

Proteomic databases

PaxDbiQ94CE3
PRIDEiQ94CE3

Genome annotation databases

EnsemblPlantsiAT4G33580.1; AT4G33580.1; AT4G33580 [Q94CE3-1]
AT4G33580.2; AT4G33580.2; AT4G33580 [Q94CE3-2]
AT4G33580.3; AT4G33580.3; AT4G33580 [Q94CE3-1]
GeneIDi829498
GrameneiAT4G33580.1; AT4G33580.1; AT4G33580 [Q94CE3-1]
AT4G33580.2; AT4G33580.2; AT4G33580 [Q94CE3-2]
AT4G33580.3; AT4G33580.3; AT4G33580 [Q94CE3-1]
KEGGiath:AT4G33580

Organism-specific databases

AraportiAT4G33580
TAIRilocus:2134218 AT4G33580

Phylogenomic databases

eggNOGiKOG1578 Eukaryota
COG0288 LUCA
HOGENOMiHOG000125183
KOiK01673
OMAiINCTFEK
OrthoDBi1136193at2759
PhylomeDBiQ94CE3

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q94CE3

Gene expression databases

ExpressionAtlasiQ94CE3 baseline and differential
GenevisibleiQ94CE3 AT

Family and domain databases

Gene3Di3.40.1050.10, 1 hit
InterProiView protein in InterPro
IPR001765 Carbonic_anhydrase
IPR015892 Carbonic_anhydrase_CS
IPR036874 Carbonic_anhydrase_sf
PfamiView protein in Pfam
PF00484 Pro_CA, 1 hit
SMARTiView protein in SMART
SM00947 Pro_CA, 1 hit
SUPFAMiSSF53056 SSF53056, 1 hit
PROSITEiView protein in PROSITE
PS00704 PROK_CO2_ANHYDRASE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCA5_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94CE3
Secondary accession number(s): B9DHL2, F4JJ03, O81875
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: December 1, 2001
Last modified: October 16, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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