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Protein

Probable pectinesterase/pectinesterase inhibitor 25

Gene

PME25

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts in the modification of cell walls via demethylesterification of cell wall pectin.By similarity

Miscellaneous

The PMEI region may act as an autoinhibitory domain and prevent untimely PME activity during transport.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pectin degradation

This protein is involved in step 1 of the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Probable pectinesterase 56 (PME56), Putative pectinesterase 11 (PME11), Pectinesterase PPME1 (PPME1), Putative pectinesterase/pectinesterase inhibitor 24 (PME24), Probable pectinesterase 30 (PME30), Probable pectinesterase/pectinesterase inhibitor 44 (PME44), Probable pectinesterase 48 (PME48), Putative pectinesterase 63 (PME63), Pectinesterase 4 (PME4), Probable pectinesterase 55 (PME55), Probable pectinesterase/pectinesterase inhibitor 58 (PME58), Probable pectinesterase 66 (PME66), Probable pectinesterase 67 (PME67), Probable pectinesterase/pectinesterase inhibitor 6 (PME6), Putative pectinesterase 10 (PME10), Probable pectinesterase/pectinesterase inhibitor 13 (PME13), Pectinesterase 2 (PME2), Probable pectinesterase/pectinesterase inhibitor 34 (PME34), Pectinesterase/pectinesterase inhibitor 3 (PME3), Putative pectinesterase/pectinesterase inhibitor 43 (PME43), Probable pectinesterase 50 (PME50), Probable pectinesterase/pectinesterase inhibitor 25 (PME25), Probable pectinesterase/pectinesterase inhibitor 33 (PME33), Probable pectinesterase/pectinesterase inhibitor 47 (PME47), Probable pectinesterase/pectinesterase inhibitor 64 (PME64), Probable pectinesterase/pectinesterase inhibitor 23 (PME23), Probable pectinesterase/pectinesterase inhibitor 35 (PME35), Probable pectinesterase/pectinesterase inhibitor 39 (PME39), Probable pectinesterase/pectinesterase inhibitor 40 (PME40), Putative pectinesterase 14 (PME14), Pectinesterase 1 (PME1), Probable pectinesterase/pectinesterase inhibitor 32 (PME32), Probable pectinesterase/pectinesterase inhibitor 51 (PME51), Putative pectinesterase/pectinesterase inhibitor 28 (PME28), Probable pectinesterase 29 (PME29), Pectinesterase 31 (PME31), Probable pectinesterase/pectinesterase inhibitor VGDH2 (VGDH2), Putative pectinesterase 52 (PME52), Putative pectinesterase 57 (PME57), Pectinesterase QRT1 (QRT1), Probable pectinesterase/pectinesterase inhibitor 36 (PME36), Putative pectinesterase/pectinesterase inhibitor 38 (PME38), Probable pectinesterase 53 (PME53), Probable pectinesterase/pectinesterase inhibitor 54 (PME54), Probable pectinesterase/pectinesterase inhibitor 59 (PME59), Pectinesterase 5 (PME5), Probable pectinesterase/pectinesterase inhibitor 61 (PME61), Probable pectinesterase/pectinesterase inhibitor 7 (PME7), Probable pectinesterase/pectinesterase inhibitor 12 (PME12), Probable pectinesterase/pectinesterase inhibitor 21 (PME21), Putative pectinesterase/pectinesterase inhibitor 45 (PME45), Probable pectinesterase 68 (PME68), Probable pectinesterase/pectinesterase inhibitor 17 (PME17), Pectinesterase/pectinesterase inhibitor 18 (PME18), Putative pectinesterase/pectinesterase inhibitor 22 (PME22), Probable pectinesterase/pectinesterase inhibitor 41 (PME41), Probable pectinesterase/pectinesterase inhibitor 42 (PME42), Probable pectinesterase/pectinesterase inhibitor 46 (PME46), Probable pectinesterase/pectinesterase inhibitor 60 (PME60), Probable pectinesterase 15 (PME15), Probable pectinesterase/pectinesterase inhibitor 16 (PME16), Probable pectinesterase 49 (PME49), Probable pectinesterase 8 (PME8), Probable pectinesterase/pectinesterase inhibitor 19 (PME19), Probable pectinesterase/pectinesterase inhibitor 20 (PME20), Putative pectinesterase/pectinesterase inhibitor 26 (PME26), Pectinesterase, Pectinesterase (AXX17_At4g02940), Pectinesterase (AXX17_At2g45340), Pectinesterase (AXX17_At5g50310), Pectinesterase (PMEPCRF), Pectinesterase (AXX17_At5g04420), Pectinesterase (AXX17_At3g10560), Pectinesterase (AXX17_At1g48290), Pectinesterase (AXX17_At5g47900), Pectinesterase (At1g53840), Pectinesterase (AXX17_At3g14900), Pectinesterase (AXX17_At3g56460), Plant invertase/pectin methylesterase inhibitor superfamily (At5g09760), Pectinesterase (AXX17_At2g22270), Pectinesterase (AXX17_At2g42790), Pectinesterase (AXX17_At2g33420), Pectinesterase (AXX17_At5g26780), Pectinesterase (At3g10720), Pectinesterase (AXX17_At4g02930), Pectinesterase (AXX17_At5g52320), Pectinesterase (AXX17_At4g02900), Pectinesterase (AXX17_At3g30550), Pectinesterase (AXX17_At3g55110), Pectinesterase (AXX17_At4g18720), Pectinesterase (AXX17_At1g24390), Pectinesterase (AXX17_At2g44780), Pectinesterase (PME44), Pectinesterase, Pectinesterase (AXX17_At4g38050), Pectinesterase (At4g15980), Pectinesterase (AXX17_At3g53530), Pectinesterase (AXX17_At3g06710), Pectinesterase (AXX17_At1g04730), Uncharacterized protein (AXX17_At3g05180), Pectinesterase, Pectinesterase (AXX17_At3g43380), Pectinesterase (PMEPCRA), Uncharacterized protein (AXX17_At5g64270), Pectinesterase (AXX17_At5g20800), Pectinesterase (AXX17_At3g26070), PME26 (AXX17_At3g14890), Pectinesterase (AXX17_At2g44790), Plant invertase/pectin methylesterase inhibitor superfamily (At3g49220), Pectinesterase (AXX17_At3g41380), Pectinesterase (At3g49220), Pectinesterase (At3g14310), Pectinesterase (AXX17_At1g11890), Pectinesterase (AXX17_At2g40510), Pectinesterase (AXX17_At4g00230), Pectinesterase (AXX17_At5g04430), Pectinesterase (AXX17_At5g50300), Uncharacterized protein (AXX17_At5g27870), Pectinesterase (AXX17_At3g31890), Pectinesterase (AXX17_At2g22280), Pectinesterase (F14I3.7), Pectinesterase (AXX17_At5g19650), Pectinesterase (AXX17_At1g48300), Uncharacterized protein (AXX17_At5g09310), Pectinesterase (At5g26810), Pectinesterase (AXX17_At1g11900), Pectinesterase (AXX17_At1g11920), Pectinesterase, Pectinesterase (AXX17_At5g45990), Pectinesterase (AXX17_At3g17940), Pectinesterase (AXX17_At2g33420), Pectinesterase (At5g20860), Pectinesterase (AXX17_At1g01970), Pectinesterase (AXX17_At4g06570), Pectinesterase (AXX17_At3g10570), Pectinesterase (AXX17_At3g05190), Pectinesterase (AXX17_At4g38040), Pectinesterase (AXX17_At3g36460)
  2. Probable pectate lyase 6 (At2g02720), Probable pectate lyase 9 (At3g24230), Putative pectate lyase 11 (At3g27400), Putative pectate lyase 2 (At1g11920), Probable pectate lyase 4 (At1g30350), Probable pectate lyase 5 (At1g67750), Probable pectate lyase 13 (PMR6), Probable pectate lyase 7 (At3g01270), Probable pectate lyase 12 (At3g53190), Probable pectate lyase 15 (At4g13710), Probable pectate lyase 3 (AT59), Probable pectate lyase 10 (At3g24670), Putative pectate lyase 14 (At4g13210), Probable pectate lyase 19 (At5g15110), Probable pectate lyase 1 (At1g04680), Probable pectate lyase 18 (At4g24780), Probable pectate lyase 20 (At5g48900), Probable pectate lyase 16 (At4g22080), Putative pectate lyase 21 (At5g55720), Probable pectate lyase 22 (At5g63180), Putative pectate lyase 17 (At4g22090), Probable pectate lyase 8 (At3g07010), Pectate lyase (AXX17_At4g25610), Pectate lyase (AXX17_At3g06910), Pectate lyase (AXX17_At2g01680), Pectate lyase (At3g07010), Pectate lyase (AXX17_At1g61710), Pectate lyase (AXX17_At5g03700), Pectate lyase (AXX17_At3g00310), Pectate lyase (AXX17_At3g26720), Pectate lyase (At4g13210), Pectate lyase (AXX17_At1g04020), Pectate lyase (At4g13710), Pectate lyase (AXX17_At4g14900), Pectate lyase, Pectate lyase (AXX17_At3g26200), Pectate lyase (At3g09540), Pectate lyase (AXX17_At4g15660), Pectate lyase, Pectate lyase (At3g27400), Pectate lyase (At3g53190), Pectate lyase (AXX17_At4g25600), Pectate lyase (AXX17_At3g49450), Pectate lyase (AXX17_At5g47570), Pectate lyase (AXX17_At3g09180), Pectate lyase (AXX17_At1g15010), Pectate lyase (At3g01270), Pectate lyase (T26I12.20), Pectate lyase (AXX17_At5g14600), Pectate lyase (AXX17_At3g49720), Pectate lyase (AXX17_At1g30780), Pectate lyase, Pectate lyase (At3g07010), Pectate lyase (At3g01270), Pectate lyase (At3g55140), Pectate lyase (AXX17_At5g62760), Pectate lyase (At3g07010), Pectate lyase (AXX17_At4g28670), Pectate lyase (At5g04310), Pectate lyase (AXX17_At1g12300), Pectate lyase, Pectate lyase (AXX17_At5g54880), Pectate lyase (AXX17_At3g29900), Pectate lyase (AXX17_At3g47590), Pectate lyase (AXX17_At5g08800), Pectate lyase (At3g55140), Pectate lyase (F11F8_12), Pectate lyase, Pectate lyase (At1g14420), Pectate lyase (At5g04310), Pectate lyase (At5g09280)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway pectin degradation, which is itself part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin, the pathway pectin degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei380Substrate; for pectinesterase activityBy similarity1
Binding sitei410Substrate; for pectinesterase activityBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei432Transition state stabilizerBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei433Proton donor; for pectinesterase activityPROSITE-ProRule annotation1
Active sitei454Nucleophile; for pectinesterase activityPROSITE-ProRule annotation1
Binding sitei522Substrate; for pectinesterase activityBy similarity1
Binding sitei524Substrate; for pectinesterase activityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • aspartyl esterase activity Source: UniProtKB-KW
  • pectinesterase activity Source: GO_Central
  • pectinesterase inhibitor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAspartyl esterase, Hydrolase
Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ARA:AT3G10720-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00545;UER00823

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable pectinesterase/pectinesterase inhibitor 25
Including the following 2 domains:
Pectinesterase inhibitor 25
Alternative name(s):
Pectin methylesterase inhibitor 25
Pectinesterase 25 (EC:3.1.1.11)
Short name:
PE 25
Alternative name(s):
Pectin methylesterase 25
Short name:
AtPME25
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PME25
Synonyms:ARATH25
Ordered Locus Names:At3g10720
ORF Names:T7M13.20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G10720

The Arabidopsis Information Resource

More...
TAIRi
locus:2103212 AT3G10720

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell wall, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000037168024 – 619Probable pectinesterase/pectinesterase inhibitor 25Add BLAST596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi312N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi325N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi447 ↔ 467By similarity
Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi550N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi591N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi596N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q94CB1

PRoteomics IDEntifications database

More...
PRIDEi
Q94CB1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in siliques.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout silique development.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q94CB1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q94CB1 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT3G10720.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q94CB1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q94CB1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni73 – 231Pectinesterase inhibitor 25Add BLAST159
Regioni302 – 601Pectinesterase 25Add BLAST300

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi32 – 89Pro-richAdd BLAST58

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the PMEI family.Curated
In the C-terminal section; belongs to the pectinesterase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGST Eukaryota
COG4677 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000217409

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q94CB1

KEGG Orthology (KO)

More...
KOi
K01051

Database of Orthologous Groups

More...
OrthoDBi
674407at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q94CB1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.140.40, 1 hit
2.160.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035513 Invertase/methylesterase_inhib
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR033131 Pectinesterase_Asp_AS
IPR000070 Pectinesterase_cat
IPR006501 Pectinesterase_inhib_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01095 Pectinesterase, 1 hit
PF04043 PMEI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00856 PMEI, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101148 SSF101148, 1 hit
SSF51126 SSF51126, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00503 PECTINESTERASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q94CB1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKMQTLNFTS SLLFLSFIFL SCALLISSQQ SPSQPHSEPP SQLPFEPPVE
60 70 80 90 100
SPFFPPSQPP IFVPPSQPPS LPPSQSQSPS LACKSTPYPK LCRTILNAVK
110 120 130 140 150
SSPSDPYRYG KFTIKQCLKQ ASRLSKVITS YARRVESKPG SATAEEIGAV
160 170 180 190 200
ADCGELSELS VNYLETVTTE LKTAQVMTAA LVEHVNSLLS GVVTNQQTCL
210 220 230 240 250
DGLVEAKSGF AAAIGSPMGN LTRLYSISLG LVSHALNRNL KRFKASKGKI
260 270 280 290 300
LGGGNSTYRE PLETLIKGLR KTCDNDKDCR KTSRNLGELG ETSGGSILVS
310 320 330 340 350
KAVIVGPFKS DNFTTITDAI AAAPNNTRPE DGYFVIYARE GVYEEYIVVP
360 370 380 390 400
INKKNLMLMG DGINKTIITG NHNVVDGWTT YNCSSFAVVG ERFMAVDVTF
410 420 430 440 450
RNTAGPEKHQ AVALRNNAEG SSFYRCSFEG YQDTLYVHSL RQFYRECDIY
460 470 480 490 500
GTVDFIFGNA AAIFQNCNIY ARKPMAKQKN AITAHGRLDP NQNTGISIIN
510 520 530 540 550
CTIKAAPDLA AEPKSAMTFL GRPWKPYSRT VFMQSYISDI VQPVGWLEWN
560 570 580 590 600
GTIGLDTIYY GEYSNFGPGA NTNQRVQWLG YNLLNLAEAM NFTVYNFTMG
610
DTWLPQTDIP FYGGLLSKE
Length:619
Mass (Da):67,956
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC37A7FE1B9A2B0C5
GO
Isoform 2 (identifier: Q94CB1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-356: Missing.

Show »
Length:263
Mass (Da):29,517
Checksum:i20129070A273EAD8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF19577 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti359M → I in AAM67242 (Ref. 4) Curated1
Sequence conflicti364N → K in AAM67242 (Ref. 4) Curated1
Sequence conflicti512E → D in AAM67242 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0370881 – 356Missing in isoform 2. 2 PublicationsAdd BLAST356

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC011708 Genomic DNA Translation: AAF19577.1 Different initiation.
CP002686 Genomic DNA Translation: AEE74946.1
CP002686 Genomic DNA Translation: AEE74947.1
AY034996 mRNA Translation: AAK59501.1
AY084383 mRNA Translation: AAM67242.1
BT029534 mRNA Translation: ABL66790.1

NCBI Reference Sequences

More...
RefSeqi
NP_187683.2, NM_111908.5 [Q94CB1-1]
NP_566379.1, NM_111909.2 [Q94CB1-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
At.19163

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT3G10720.1; AT3G10720.1; AT3G10720 [Q94CB1-2]
AT3G10720.2; AT3G10720.2; AT3G10720 [Q94CB1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
820241

Gramene; a comparative resource for plants

More...
Gramenei
AT3G10720.1; AT3G10720.1; AT3G10720 [Q94CB1-2]
AT3G10720.2; AT3G10720.2; AT3G10720 [Q94CB1-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT3G10720

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011708 Genomic DNA Translation: AAF19577.1 Different initiation.
CP002686 Genomic DNA Translation: AEE74946.1
CP002686 Genomic DNA Translation: AEE74947.1
AY034996 mRNA Translation: AAK59501.1
AY084383 mRNA Translation: AAM67242.1
BT029534 mRNA Translation: ABL66790.1
RefSeqiNP_187683.2, NM_111908.5 [Q94CB1-1]
NP_566379.1, NM_111909.2 [Q94CB1-2]
UniGeneiAt.19163

3D structure databases

ProteinModelPortaliQ94CB1
SMRiQ94CB1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G10720.2

Proteomic databases

PaxDbiQ94CB1
PRIDEiQ94CB1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G10720.1; AT3G10720.1; AT3G10720 [Q94CB1-2]
AT3G10720.2; AT3G10720.2; AT3G10720 [Q94CB1-1]
GeneIDi820241
GrameneiAT3G10720.1; AT3G10720.1; AT3G10720 [Q94CB1-2]
AT3G10720.2; AT3G10720.2; AT3G10720 [Q94CB1-1]
KEGGiath:AT3G10720

Organism-specific databases

AraportiAT3G10720
TAIRilocus:2103212 AT3G10720

Phylogenomic databases

eggNOGiENOG410IGST Eukaryota
COG4677 LUCA
HOGENOMiHOG000217409
InParanoidiQ94CB1
KOiK01051
OrthoDBi674407at2759
PhylomeDBiQ94CB1

Enzyme and pathway databases

UniPathwayi
UPA00545;UER00823

BioCyciARA:AT3G10720-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q94CB1

Gene expression databases

ExpressionAtlasiQ94CB1 baseline and differential
GenevisibleiQ94CB1 AT

Family and domain databases

Gene3Di1.20.140.40, 1 hit
2.160.20.10, 1 hit
InterProiView protein in InterPro
IPR035513 Invertase/methylesterase_inhib
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR033131 Pectinesterase_Asp_AS
IPR000070 Pectinesterase_cat
IPR006501 Pectinesterase_inhib_dom
PfamiView protein in Pfam
PF01095 Pectinesterase, 1 hit
PF04043 PMEI, 1 hit
SMARTiView protein in SMART
SM00856 PMEI, 1 hit
SUPFAMiSSF101148 SSF101148, 1 hit
SSF51126 SSF51126, 1 hit
PROSITEiView protein in PROSITE
PS00503 PECTINESTERASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPME25_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94CB1
Secondary accession number(s): Q3EB96, Q8LGA3, Q9SG78
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: December 1, 2001
Last modified: January 16, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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