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Protein

Protein PAM71, chloroplastic

Gene

PAM71

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mn2+/H+ exchanger, which transport Mn2+from the chloroplast stroma into the acidic thylakoid lumen (PubMed:27020959). Might be a chloroplast-localized Ca2+/H+ antiporter (PubMed:27302341). Regulates Ca2+, Mn2+ and pH homeostasis (PubMed:27302341). Required for chloroplast development (PubMed:27302341).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • magnesium ion transmembrane transporter activity Source: TAIR
  • manganese ion transmembrane transporter activity Source: TAIR

GO - Biological processi

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.106.1.5 the ca(2+):h(+) antiporter-2 (caca2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PAM71, chloroplastic1 Publication
Alternative name(s):
CA(2+)/H(+) ANTIPORTER 11 Publication
GDT1-like protein 1Curated
PHOTOSYNTHESIS AFFECTED MUTANT711 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PAM711 Publication
Synonyms:CCHA11 Publication
Ordered Locus Names:At1g64150Imported
ORF Names:F22C12.9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT1G64150

The Arabidopsis Information Resource

More...
TAIRi
locus:2024628 AT1G64150

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini74 – 113StromalCuratedAdd BLAST40
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 161Lumenal, thylakoidCuratedAdd BLAST27
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 188StromalCurated6
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 228Lumenal, thylakoidCuratedAdd BLAST19
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 275StromalCuratedAdd BLAST26
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Topological domaini297 – 315Lumenal, thylakoidCuratedAdd BLAST19
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 348StromalCuratedAdd BLAST12
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Topological domaini370Lumenal, thylakoid1 Publication1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Chloroplast, Membrane, Plastid, Thylakoid

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Defects in photosynthesis and reduced growth rate (PubMed:27302341, PubMed:27020959). Pale yellow leaves with reduced PSII activity (PubMed:27302341). Altered Ca2+ and Mn2+ partitioning in chloroplasts and reduced Mn2+ binding to PSII (PubMed:27020959).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 73ChloroplastSequence analysisAdd BLAST73
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000039876474 – 370Protein PAM71, chloroplasticAdd BLAST297

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q94AX5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q94AX5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q94AX5 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
27940, 25 interactors

Protein interaction database and analysis system

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IntActi
Q94AX5, 25 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G64150.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q94AX5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q94AX5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GDT1 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2881 Eukaryota
COG2119 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000224541

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q94AX5

Identification of Orthologs from Complete Genome Data

More...
OMAi
VRCISSK

Database of Orthologous Groups

More...
OrthoDBi
EOG09360K8B

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q94AX5

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001727 Gdt1

The PANTHER Classification System

More...
PANTHERi
PTHR12608 PTHR12608, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01169 UPF0016, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01214 UPF0016, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q94AX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSLNLSESL RIPFQNPRPP KSDFSSTSSS PSSSSRRCVS AYPIPIGFSV
60 70 80 90 100
RNQYFSRCLT QLRRNESQQL GFRCFQRNDA ACYLEKAESE EHDRNLDVLV
110 120 130 140 150
ESSIAHSRRE IQRVLMFLAV SGSVALLGTD PAFAASSIPN VTQSLVTSFG
160 170 180 190 200
DLGDISSGFA SAFLLIFFSE LGDKTFFIAA LLAARNSAAT VFVGTFGALG
210 220 230 240 250
IMTIISVVLG RTFHYVDEVL PFRFGGTDLP IDDIAAVCLL VYFGVSTLLD
260 270 280 290 300
AVSDEGKADE EQKEAELAVS ELSGNGAGIV AAANTIISTF ALVFVAEWGD
310 320 330 340 350
KSFFSTIALA AASSPLGVIA GALAGHGAAT LLAVLGGSLL GNFLSEKAIA
360 370
YVGGVLFLVF AAVTVAEIVT
Length:370
Mass (Da):39,074
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D3FF0E824889BE7
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF24562 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54Y → S in AAN28814 (PubMed:14593172).Curated1
Sequence conflicti54Y → S in AAK73997 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC007764 Genomic DNA Translation: AAF24562.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE34202.1
AY045639 mRNA Translation: AAK73997.1
AY143875 mRNA Translation: AAN28814.1

NCBI Reference Sequences

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RefSeqi
NP_564825.1, NM_105088.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
At.26167

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G64150.1; AT1G64150.1; AT1G64150

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
842719

Gramene; a comparative resource for plants

More...
Gramenei
AT1G64150.1; AT1G64150.1; AT1G64150

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G64150

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007764 Genomic DNA Translation: AAF24562.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE34202.1
AY045639 mRNA Translation: AAK73997.1
AY143875 mRNA Translation: AAN28814.1
RefSeqiNP_564825.1, NM_105088.4
UniGeneiAt.26167

3D structure databases

ProteinModelPortaliQ94AX5
SMRiQ94AX5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi27940, 25 interactors
IntActiQ94AX5, 25 interactors
STRINGi3702.AT1G64150.1

Protein family/group databases

TCDBi2.A.106.1.5 the ca(2+):h(+) antiporter-2 (caca2) family

Proteomic databases

PaxDbiQ94AX5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G64150.1; AT1G64150.1; AT1G64150
GeneIDi842719
GrameneiAT1G64150.1; AT1G64150.1; AT1G64150
KEGGiath:AT1G64150

Organism-specific databases

AraportiAT1G64150
TAIRilocus:2024628 AT1G64150

Phylogenomic databases

eggNOGiKOG2881 Eukaryota
COG2119 LUCA
HOGENOMiHOG000224541
InParanoidiQ94AX5
OMAiVRCISSK
OrthoDBiEOG09360K8B
PhylomeDBiQ94AX5

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q94AX5

Gene expression databases

ExpressionAtlasiQ94AX5 baseline and differential
GenevisibleiQ94AX5 AT

Family and domain databases

InterProiView protein in InterPro
IPR001727 Gdt1
PANTHERiPTHR12608 PTHR12608, 1 hit
PfamiView protein in Pfam
PF01169 UPF0016, 2 hits
PROSITEiView protein in PROSITE
PS01214 UPF0016, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAM71_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94AX5
Secondary accession number(s): Q9SH65
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 70 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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