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Entry version 146 (02 Dec 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Cullin-1

Gene

CUL1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Regulator of mitotic processes which plays a role during gametogenesis and embryogenesis. Together with SKP1, RBX1 and a F-box protein, it forms a SCF complex. The functional specificity of this complex depends of the type of F-box protein. SCF(UFO) is implicated in floral organ development. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1/ZTL), SCF(ADO2/LKP2), SCF(ADO3/FKF1) are related to the circadian clock. SCF(ORE9) seems to be involved in senescence. SCF(EBF1/EBF2) may regulate ethylene signaling.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processAuxin signaling pathway, Cell cycle, Ethylene signaling pathway, Ubl conjugation pathway

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cullin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CUL1
Ordered Locus Names:At4g02570
ORF Names:T10P11.26
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT4G02570

The Arabidopsis Information Resource

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TAIRi
locus:2132377, AT4G02570

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi682K → M: No neddylation. 2 Publications1
Mutagenesisi712K → M: No change in neddylation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001198041 – 738Cullin-1Add BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki682Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Neddylated (rubylated). Deneddylation occurs upon interaction with the COP9 signalosome (CSN) complex.2 Publications

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q94AH6

PRoteomics IDEntifications database

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PRIDEi
Q94AH6

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
220459

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed constitutively in roots, seedlings, stems, leaves and flowers.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Strong accumulation in embryos (at protein level).1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q94AH6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q94AH6, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of E3 ubiquitin ligase SCF complexes such as SCF(TIR1) and SCF(COI1). SCF(TIR1) is composed of CUL1, SKP1 (SKP1A or SKP1B), RBX1 (RBX1A or RBX1B) and TIR1, while SCF(COI1) is composed of CUL1, SKP1, RBX1 and COI1. A SNF1-related protein kinase (KIN10 and KIN11) can also be part of these SCF complexes. SCF(TIR1) is able to interact with the COP9 signalosome (CSN) complex.

Interacts directly with some F-box proteins such as DOR, SKIP14, FBW2/SKIP18, SKIP19/FBL20 and SKIP28/MEE11.

Interacts with CAND1.

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
10962, 47 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1339, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1A
CPX-1343, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1A
CPX-1429, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1B
CPX-1430, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK3
CPX-1431, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK4
CPX-1432, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK5
CPX-1433, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK6
CPX-1434, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK7
CPX-1435, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK8
CPX-1436, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK9
CPX-1437, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK10
CPX-1438, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK11
CPX-1439, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK12
CPX-1440, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK13
CPX-1441, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK14
CPX-1442, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK15
CPX-1443, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK16
CPX-1444, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK17
CPX-1445, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK18
CPX-1446, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK19
CPX-1447, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK20
CPX-1448, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK21
CPX-1449, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-SKP1A
CPX-1450, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-SKP1B
CPX-1451, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK3
CPX-1452, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK4
CPX-1453, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK5
CPX-1454, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK6
CPX-1455, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK7
CPX-1456, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK8
CPX-1457, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK9
CPX-1458, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK10
CPX-1459, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK11
CPX-1460, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK12
CPX-1461, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK13
CPX-1462, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK14
CPX-1463, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK15
CPX-1464, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK16
CPX-1465, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK17
CPX-1466, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK18
CPX-1467, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK19
CPX-1468, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK20
CPX-1469, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK21
CPX-1515, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1B
CPX-1516, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK3
CPX-1517, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK4
CPX-1518, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK5
CPX-1519, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK6
CPX-1520, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK7
CPX-1521, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK8
CPX-1522, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK9
CPX-1523, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK10
CPX-1524, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK11
CPX-1525, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK12
CPX-1526, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK13
CPX-1527, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK14
CPX-1528, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK15
CPX-1529, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK16
CPX-1530, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK17
CPX-1531, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK18
CPX-1532, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK19
CPX-1533, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK20
CPX-1534, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK21
CPX-1535, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-SKP1A
CPX-1536, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-SKP1B
CPX-1537, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK3
CPX-1538, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK4
CPX-1539, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK5
CPX-1540, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK6
CPX-1541, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK7
CPX-1542, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK8
CPX-1543, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK9
CPX-1544, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK10
CPX-1545, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK11
CPX-1546, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK12
CPX-1547, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK13
CPX-1548, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK14
CPX-1549, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK15
CPX-1550, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK16
CPX-1551, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK17
CPX-1552, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK18
CPX-1553, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK19
CPX-1554, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK20
CPX-1555, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK21

Database of interacting proteins

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DIPi
DIP-33346N

Protein interaction database and analysis system

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IntActi
Q94AH6, 36 interactors

STRING: functional protein association networks

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STRINGi
3702.AT4G02570.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q94AH6

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cullin family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2166, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_004747_3_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q94AH6

Identification of Orthologs from Complete Genome Data

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OMAi
VITPEYW

Database of Orthologous Groups

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OrthoDBi
1040292at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q94AH6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016157, Cullin_CS
IPR016158, Cullin_homology
IPR036317, Cullin_homology_sf
IPR001373, Cullin_N
IPR019559, Cullin_neddylation_domain
IPR016159, Cullin_repeat-like_dom_sf
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00888, Cullin, 1 hit
PF10557, Cullin_Nedd8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00182, CULLIN, 1 hit
SM00884, Cullin_Nedd8, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46785, SSF46785, 1 hit
SSF74788, SSF74788, 1 hit
SSF75632, SSF75632, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01256, CULLIN_1, 1 hit
PS50069, CULLIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q94AH6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERKTIDLEQ GWDYMQTGIT KLKRILEGLN EPAFDSEQYM MLYTTIYNMC
60 70 80 90 100
TQKPPHDYSQ QLYDKYREAF EEYINSTVLP ALREKHDEFM LRELFKRWSN
110 120 130 140 150
HKVMVRWLSR FFYYLDRYFI ARRSLPPLNE VGLTCFRDLV YNELHSKVKQ
160 170 180 190 200
AVIALVDKER EGEQIDRALL KNVLDIYVEI GMGQMERYEE DFESFMLQDT
210 220 230 240 250
SSYYSRKASS WIQEDSCPDY MLKSEECLKK ERERVAHYLH SSSEPKLVEK
260 270 280 290 300
VQHELLVVFA SQLLEKEHSG CRALLRDDKV DDLSRMYRLY HKILRGLEPV
310 320 330 340 350
ANIFKQHVTA EGNALVQQAE DTATNQVANT ASVQEQVLIR KVIELHDKYM
360 370 380 390 400
VYVTECFQNH TLFHKALKEA FEIFCNKTVA GSSSAELLAT FCDNILKKGG
410 420 430 440 450
SEKLSDEAIE DTLEKVVKLL AYISDKDLFA EFYRKKLARR LLFDRSANDD
460 470 480 490 500
HERSILTKLK QQCGGQFTSK MEGMVTDLTL ARENQNSFED YLGSNPAANP
510 520 530 540 550
GIDLTVTVLT TGFWPSYKSF DINLPSEMIK CVEVFKGFYE TKTKHRKLTW
560 570 580 590 600
IYSLGTCHIN GKFDQKAIEL IVSTYQAAVL LLFNTTDKLS YTEILAQLNL
610 620 630 640 650
SHEDLVRLLH SLSCAKYKIL LKEPNTKTVS QNDAFEFNSK FTDRMRRIKI
660 670 680 690 700
PLPPVDERKK VVEDVDKDRR YAIDAAIVRI MKSRKVLGHQ QLVSECVEQL
710 720 730
SRMFKPDIKA IKKRMEDLIT RDYLERDKEN PNMFRYLA
Length:738
Mass (Da):86,302
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45041357DE8DAD8C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC78267 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB80750 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ318017 mRNA Translation: CAC85264.1
AC002330 Genomic DNA Translation: AAC78267.1 Sequence problems.
AL161494 Genomic DNA Translation: CAB80750.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE82194.1
CP002687 Genomic DNA Translation: AEE82195.1
CP002687 Genomic DNA Translation: AEE82196.1
CP002687 Genomic DNA Translation: AEE82197.1
AY046030 mRNA Translation: AAK76704.1
AY133878 mRNA Translation: AAM91812.1
AK222216 mRNA Translation: BAD95380.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T01092

NCBI Reference Sequences

More...
RefSeqi
NP_001031575.1, NM_001036498.3
NP_001031576.1, NM_001036499.1
NP_001190661.1, NM_001203732.1
NP_567243.1, NM_116491.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G02570.1; AT4G02570.1; AT4G02570
AT4G02570.2; AT4G02570.2; AT4G02570
AT4G02570.3; AT4G02570.3; AT4G02570
AT4G02570.4; AT4G02570.4; AT4G02570

Database of genes from NCBI RefSeq genomes

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GeneIDi
825648

Gramene; a comparative resource for plants

More...
Gramenei
AT4G02570.1; AT4G02570.1; AT4G02570
AT4G02570.2; AT4G02570.2; AT4G02570
AT4G02570.3; AT4G02570.3; AT4G02570
AT4G02570.4; AT4G02570.4; AT4G02570

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G02570

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318017 mRNA Translation: CAC85264.1
AC002330 Genomic DNA Translation: AAC78267.1 Sequence problems.
AL161494 Genomic DNA Translation: CAB80750.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE82194.1
CP002687 Genomic DNA Translation: AEE82195.1
CP002687 Genomic DNA Translation: AEE82196.1
CP002687 Genomic DNA Translation: AEE82197.1
AY046030 mRNA Translation: AAK76704.1
AY133878 mRNA Translation: AAM91812.1
AK222216 mRNA Translation: BAD95380.1
PIRiT01092
RefSeqiNP_001031575.1, NM_001036498.3
NP_001031576.1, NM_001036499.1
NP_001190661.1, NM_001203732.1
NP_567243.1, NM_116491.3

3D structure databases

SMRiQ94AH6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi10962, 47 interactors
ComplexPortaliCPX-1339, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1A
CPX-1343, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1A
CPX-1429, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1B
CPX-1430, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK3
CPX-1431, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK4
CPX-1432, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK5
CPX-1433, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK6
CPX-1434, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK7
CPX-1435, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK8
CPX-1436, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK9
CPX-1437, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK10
CPX-1438, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK11
CPX-1439, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK12
CPX-1440, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK13
CPX-1441, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK14
CPX-1442, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK15
CPX-1443, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK16
CPX-1444, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK17
CPX-1445, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK18
CPX-1446, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK19
CPX-1447, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK20
CPX-1448, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK21
CPX-1449, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-SKP1A
CPX-1450, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-SKP1B
CPX-1451, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK3
CPX-1452, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK4
CPX-1453, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK5
CPX-1454, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK6
CPX-1455, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK7
CPX-1456, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK8
CPX-1457, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK9
CPX-1458, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK10
CPX-1459, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK11
CPX-1460, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK12
CPX-1461, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK13
CPX-1462, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK14
CPX-1463, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK15
CPX-1464, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK16
CPX-1465, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK17
CPX-1466, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK18
CPX-1467, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK19
CPX-1468, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK20
CPX-1469, SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK21
CPX-1515, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1B
CPX-1516, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK3
CPX-1517, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK4
CPX-1518, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK5
CPX-1519, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK6
CPX-1520, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK7
CPX-1521, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK8
CPX-1522, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK9
CPX-1523, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK10
CPX-1524, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK11
CPX-1525, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK12
CPX-1526, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK13
CPX-1527, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK14
CPX-1528, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK15
CPX-1529, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK16
CPX-1530, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK17
CPX-1531, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK18
CPX-1532, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK19
CPX-1533, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK20
CPX-1534, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK21
CPX-1535, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-SKP1A
CPX-1536, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-SKP1B
CPX-1537, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK3
CPX-1538, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK4
CPX-1539, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK5
CPX-1540, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK6
CPX-1541, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK7
CPX-1542, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK8
CPX-1543, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK9
CPX-1544, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK10
CPX-1545, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK11
CPX-1546, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK12
CPX-1547, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK13
CPX-1548, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK14
CPX-1549, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK15
CPX-1550, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK16
CPX-1551, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK17
CPX-1552, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK18
CPX-1553, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK19
CPX-1554, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK20
CPX-1555, SCF(TIR1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK21
DIPiDIP-33346N
IntActiQ94AH6, 36 interactors
STRINGi3702.AT4G02570.4

Proteomic databases

PaxDbiQ94AH6
PRIDEiQ94AH6
ProteomicsDBi220459

Genome annotation databases

EnsemblPlantsiAT4G02570.1; AT4G02570.1; AT4G02570
AT4G02570.2; AT4G02570.2; AT4G02570
AT4G02570.3; AT4G02570.3; AT4G02570
AT4G02570.4; AT4G02570.4; AT4G02570
GeneIDi825648
GrameneiAT4G02570.1; AT4G02570.1; AT4G02570
AT4G02570.2; AT4G02570.2; AT4G02570
AT4G02570.3; AT4G02570.3; AT4G02570
AT4G02570.4; AT4G02570.4; AT4G02570
KEGGiath:AT4G02570

Organism-specific databases

AraportiAT4G02570
TAIRilocus:2132377, AT4G02570

Phylogenomic databases

eggNOGiKOG2166, Eukaryota
HOGENOMiCLU_004747_3_0_1
InParanoidiQ94AH6
OMAiVITPEYW
OrthoDBi1040292at2759
PhylomeDBiQ94AH6

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q94AH6

Gene expression databases

ExpressionAtlasiQ94AH6, baseline and differential
GenevisibleiQ94AH6, AT

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016157, Cullin_CS
IPR016158, Cullin_homology
IPR036317, Cullin_homology_sf
IPR001373, Cullin_N
IPR019559, Cullin_neddylation_domain
IPR016159, Cullin_repeat-like_dom_sf
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF00888, Cullin, 1 hit
PF10557, Cullin_Nedd8, 1 hit
SMARTiView protein in SMART
SM00182, CULLIN, 1 hit
SM00884, Cullin_Nedd8, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF74788, SSF74788, 1 hit
SSF75632, SSF75632, 1 hit
PROSITEiView protein in PROSITE
PS01256, CULLIN_1, 1 hit
PS50069, CULLIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUL1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94AH6
Secondary accession number(s): O22770, Q56W31
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: December 2, 2020
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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