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Entry version 102 (31 Jul 2019)
Sequence version 1 (01 Dec 2001)
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Protein

CSC1-like protein At1g10090

Gene

At1g10090

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an osmosensitive calcium-permeable cation channel.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CSC1-like protein At1g10090
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:At1g10090
ORF Names:T27I1.10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT1G10090

The Arabidopsis Information Resource

More...
TAIRi
locus:2201876 AT1G10090

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Transmembranei557 – 577HelicalSequence analysisAdd BLAST21
Transmembranei594 – 614HelicalSequence analysisAdd BLAST21
Transmembranei615 – 635HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004298071 – 762CSC1-like protein At1g10090Add BLAST762

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q94A87

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q94A87

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q94A87 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q94A87 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
22784, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q94A87, 4 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G10090.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q94A87

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1134 Eukaryota
COG5594 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000241414

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q94A87

KEGG Orthology (KO)

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KOi
K21989

Identification of Orthologs from Complete Genome Data

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OMAi
QTSNPME

Database of Orthologous Groups

More...
OrthoDBi
395194at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q94A87

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032880 Csc1_N
IPR027815 PHM7_cyt
IPR003864 RSN1_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14703 PHM7_cyt, 1 hit
PF02714 RSN1_7TM, 1 hit
PF13967 RSN1_TM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q94A87-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVSALLTSA GINIAICVVL VSLYSILRKQ PANYCVYFGR LLSDGRVKRH
60 70 80 90 100
DPRWYERFAP SPSWLVKAWE TTEEEMLAAA GLDAVVFIRM VICSIRIFSI
110 120 130 140 150
VAVVCLAFVL PVNYYGQKME HKEVHLESLG VFTIENLNPR SRWLWVHCLS
160 170 180 190 200
LYIISSAACA LLYFEYKNIA KKRLAHISGS ASKPSHFTVL IRAIPQSPDQ
210 220 230 240 250
SYSETVSKYF TNYYAPSYVS HLMVYRDGFI HRLMNETERM CQAIKHVSPD
260 270 280 290 300
LSCNPSLKSC VLCGPAATNS FQIISNETDS VKGLELGELT LTTTEEERPV
310 320 330 340 350
AFVFFKSRYD ALVVSEVLQT PNPMLWVADL APEPHDVHWR NLRIPYRQLW
360 370 380 390 400
MRRIATLVGA IAFMFVFLFP VTFVQGLTQL PTLSKNFPFL KDLLNRRFME
410 420 430 440 450
QVITGYLPSV ILVLFFYTVP PLMMYFSTLE GCVSRSQRKK SACLKILYFT
460 470 480 490 500
IWNVFFVNIL SGSVIRQFTV LNSVRDVPAQ LAKLVPAQAG FFMTYCFTSG
510 520 530 540 550
WAGLACEIMQ PVGLIWNLIA KVIVKNKEES YETLRFPYHT EIPRLLLFGL
560 570 580 590 600
LGFTNSVIAP LILPFLLIYF FFAYLIYKNQ IINVYITKYE SGGQYWPVFH
610 620 630 640 650
NTTIFSLILS QVIALGFFGL KLSTVASGFT IPLILLTLLF SEYCRQRFAP
660 670 680 690 700
IFQKYPAEIL IAMDRADEMT GKMEEIHNNL KVAYSQIPTC SEESSKAGCT
710 720 730 740 750
SPCSDQELPD SEELKPEKEN LKADYIWEFQ RSKSGLDLEV KSCPSASPIR
760
NSPGFAEIYK RT
Length:762
Mass (Da):86,768
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1E37ED4D54F9642
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC34338 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti94S → I in AAM63909 (Ref. 5) Curated1
Sequence conflicti195P → L in BAD43330 (Ref. 4) Curated1
Sequence conflicti438R → K in AAM63909 (Ref. 5) Curated1
Sequence conflicti471L → F in AAM63909 (Ref. 5) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC004122 Genomic DNA Translation: AAC34338.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28540.1
AY049273 mRNA Translation: AAK83615.1
AK175567 mRNA Translation: BAD43330.1
AK176422 mRNA Translation: BAD44185.1
AK176455 mRNA Translation: BAD44218.1
AY086862 mRNA Translation: AAM63909.1

Protein sequence database of the Protein Information Resource

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PIRi
T00627

NCBI Reference Sequences

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RefSeqi
NP_172480.2, NM_100883.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G10090.1; AT1G10090.1; AT1G10090

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
837544

Gramene; a comparative resource for plants

More...
Gramenei
AT1G10090.1; AT1G10090.1; AT1G10090

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G10090

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004122 Genomic DNA Translation: AAC34338.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28540.1
AY049273 mRNA Translation: AAK83615.1
AK175567 mRNA Translation: BAD43330.1
AK176422 mRNA Translation: BAD44185.1
AK176455 mRNA Translation: BAD44218.1
AY086862 mRNA Translation: AAM63909.1
PIRiT00627
RefSeqiNP_172480.2, NM_100883.3

3D structure databases

SMRiQ94A87
ModBaseiSearch...

Protein-protein interaction databases

BioGridi22784, 4 interactors
IntActiQ94A87, 4 interactors
STRINGi3702.AT1G10090.1

PTM databases

iPTMnetiQ94A87

Proteomic databases

PaxDbiQ94A87

Genome annotation databases

EnsemblPlantsiAT1G10090.1; AT1G10090.1; AT1G10090
GeneIDi837544
GrameneiAT1G10090.1; AT1G10090.1; AT1G10090
KEGGiath:AT1G10090

Organism-specific databases

AraportiAT1G10090
TAIRilocus:2201876 AT1G10090

Phylogenomic databases

eggNOGiKOG1134 Eukaryota
COG5594 LUCA
HOGENOMiHOG000241414
InParanoidiQ94A87
KOiK21989
OMAiQTSNPME
OrthoDBi395194at2759
PhylomeDBiQ94A87

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q94A87

Gene expression databases

ExpressionAtlasiQ94A87 baseline and differential
GenevisibleiQ94A87 AT

Family and domain databases

InterProiView protein in InterPro
IPR032880 Csc1_N
IPR027815 PHM7_cyt
IPR003864 RSN1_7TM
PfamiView protein in Pfam
PF14703 PHM7_cyt, 1 hit
PF02714 RSN1_7TM, 1 hit
PF13967 RSN1_TM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSCL9_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94A87
Secondary accession number(s): O80599, Q681Q0, Q8LC14
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: December 1, 2001
Last modified: July 31, 2019
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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