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UniProtKB - Q94A40 (COPA1_ARATH)

Entry version 123 (18 Sep 2019)
Sequence version 2 (01 May 2007)
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Protein

Coatomer subunit alpha-1

Gene

At1g62020

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coatomer subunit alpha-1
Alternative name(s):
Alpha-coat protein 1
Short name:
Alpha-COP 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:At1g62020
ORF Names:F8K4.21
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...Araporti		AT1G62020

The Arabidopsis Information Resource

More...TAIRi		locus:2036823 AT1G62020

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002855991 – 1216Coatomer subunit alpha-1Add BLAST1216

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q94A40

PRoteomics IDEntifications database

More...PRIDEi		Q94A40

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q94A40

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q94A40 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q94A40 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q94A40, 1 interactor

STRING: functional protein association networks

More...STRINGi		3702.AT1G62020.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q94A40

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati7 – 48WD 1Add BLAST42
Repeati49 – 88WD 2Add BLAST40
Repeati91 – 132WD 3Add BLAST42
Repeati133 – 172WD 4Add BLAST40
Repeati202 – 241WD 5Add BLAST40
Repeati246 – 285WD 6Add BLAST40
Repeati288 – 326WD 7Add BLAST39
Repeati363 – 404WD 8Add BLAST42

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0292 Eukaryota
ENOG410XPZS LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000195913

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q94A40

KEGG Orthology (KO)

More...KOi		K05236

Identification of Orthologs from Complete Genome Data

More...OMAi		GNMLYYV

Database of Orthologous Groups

More...OrthoDBi		139008at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q94A40

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024977 Apc4_WD40_dom
IPR016391 Coatomer_asu
IPR010714 Coatomer_asu_C
IPR006692 Coatomer_WD-assoc_reg
IPR020472 G-protein_beta_WD-40_rep
IPR011048 Haem_d1_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF04053 Coatomer_WDAD, 1 hit
PF06957 COPI_C, 1 hit
PF00400 WD40, 3 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF003354 Coatomer_alpha_subunit, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50978 SSF50978, 1 hit
SSF51004 SSF51004, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q94A40-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTKFETKSN RVKGLSFHPK RPWILASLHS GVIQLWDYRM GTLIDRFDEH 
        60         70         80         90        100
EGPVRGVHFH NSQPLFVSGG DDYKIKVWNY KNHRCLFTLL GHLDYIRTVQ 
       110        120        130        140        150
FHHEYPWIVS ASDDQTIRIW NWQSRTCVSV LTGHNHYVMC ASFHPKEDLV 
       160        170        180        190        200
VSASLDQTVR VWDIGALRKK TVSPADDIMR LTQMNSDLFG GVDAIVKYVL 
       210        220        230        240        250
EGHDRGVNWA AFHPTLPLIV SGADDRQVKL WRMNETKAWE VDTLRGHMNN 
       260        270        280        290        300
VSSVMFHAKQ DIIVSNSEDK SIRVWDATKR TGLQTFRREH DRFWILAVHP 
       310        320        330        340        350
EMNLLAAGHD SGMIVFKLER ERPAFALSGD SLFYAKDRFL RYYEYSTQRD 
       360        370        380        390        400
SQVIPIRRPG TPSLNQSPRT LSYSPTENAV LICSDLDGGS YELYIIPKDS 
       410        420        430        440        450
VGRSDVVQDA KRGTGGSAVF IARNRFAVLE KSTSQVLVKN LKNEVVKKSP 
       460        470        480        490        500
LPIPTDAIFY AGTGNLLCRS EDKVVIFDLQ QRLVLGELQT PFVRYVVWSS 
       510        520        530        540        550
DMESVALLSK HTIIIASKKL VLQCTLHETI RVKSGAWDDN GVFIYTTLNH 
       560        570        580        590        600
IKYCLPNGDS GIIRTLDVPI YITKVSGNTI FCLDRDGKNK AITINATEYI 
       610        620        630        640        650
FKLSLLRKRY DHVMSMIKNS QLCGQAMIAY LQQKGFPEVA LHFVEDERIR 
       660        670        680        690        700
FNLALESGNI SVAVASATQI NEKDHWYRLG VEALRQGNSG IVEFAYQQTK 
       710        720        730        740        750
NFERLSFLYL ITGNLDKLSK LMKIAEVKNN VMGQFHNALY LGDVKERVKI 
       760        770        780        790        800
LENAGHLPLA YITASVHGLN DIAERLATEL GDNVPSLPEG KTPSLLMPPT 
       810        820        830        840        850
PIMCGGDWPL LRVMKGIFEG GLESADRGGT VDEEDVEGDW GEELDINVDG 
       860        870        880        890        900
MENRDIEDIL AAAEAGEEEN DEEGGWGLED LVLPPELDTP KASANARSSV 
       910        920        930        940        950
FVTPPQGMPV SQSWSQKSSL AAEQAAAGSF DTAMRLLHRQ LGIKNFTPLK 
       960        970        980        990       1000
SMFLDLFNGS HSYLRAFSSC PVVPLAIERG WSESSSPNVR SPPALVYDFS 
      1010       1020       1030       1040       1050
QLDEKLKSGY KATTTGKFTE ALRLFLSILH TIPLVVVETR REVDEVKELI 
      1060       1070       1080       1090       1100
VIVKEYVLGL QMELKRREMK DDPVRQQELA AYFTHCNLQT PHLRLALLSA 
      1110       1120       1130       1140       1150
MGVCYKAKNL ATASNFARRL LETSPVDSQA KMARQVVQAA ERNMTDETKL 
      1160       1170       1180       1190       1200
NYDFRNPFVV CGSTYVPIYR GQKDVSCPYC TARFVPNQEG NICTVCDLAV 
      1210 
IGADASGLLC SPSQVR
Length:1,216
Mass (Da):136,566
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79FC84DC14A481B5
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK91416 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAN46802 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC004392 Genomic DNA Translation: AAC28519.1
CP002684 Genomic DNA Translation: AEE33914.1
AY050400 mRNA Translation: AAK91416.1 Different initiation.
BT001048 mRNA Translation: AAN46802.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...PIRi		T02146

NCBI Reference Sequences

More...RefSeqi		NP_176393.1, NM_104882.5

Genome annotation databases

Ensembl plant genome annotation project

More...EnsemblPlantsi		AT1G62020.1; AT1G62020.1; AT1G62020

Database of genes from NCBI RefSeq genomes

More...GeneIDi		842497

Gramene; a comparative resource for plants

More...Gramenei		AT1G62020.1; AT1G62020.1; AT1G62020

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ath:AT1G62020

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004392 Genomic DNA Translation: AAC28519.1
CP002684 Genomic DNA Translation: AEE33914.1
AY050400 mRNA Translation: AAK91416.1 Different initiation.
BT001048 mRNA Translation: AAN46802.1 Different initiation.
PIRiT02146
RefSeqiNP_176393.1, NM_104882.5

3D structure databases

SMRiQ94A40
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ94A40, 1 interactor
STRINGi3702.AT1G62020.1

PTM databases

iPTMnetiQ94A40

Proteomic databases

PaxDbiQ94A40
PRIDEiQ94A40

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G62020.1; AT1G62020.1; AT1G62020
GeneIDi842497
GrameneiAT1G62020.1; AT1G62020.1; AT1G62020
KEGGiath:AT1G62020

Organism-specific databases

AraportiAT1G62020
TAIRilocus:2036823 AT1G62020

Phylogenomic databases

eggNOGiKOG0292 Eukaryota
ENOG410XPZS LUCA
HOGENOMiHOG000195913
InParanoidiQ94A40
KOiK05236
OMAiGNMLYYV
OrthoDBi139008at2759
PhylomeDBiQ94A40

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q94A40

Gene expression databases

ExpressionAtlasiQ94A40 baseline and differential
GenevisibleiQ94A40 AT

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR016391 Coatomer_asu
IPR010714 Coatomer_asu_C
IPR006692 Coatomer_WD-assoc_reg
IPR020472 G-protein_beta_WD-40_rep
IPR011048 Haem_d1_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF04053 Coatomer_WDAD, 1 hit
PF06957 COPI_C, 1 hit
PF00400 WD40, 3 hits
PIRSFiPIRSF003354 Coatomer_alpha_subunit, 1 hit
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF51004 SSF51004, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOPA1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94A40
Secondary accession number(s): O80706
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: September 18, 2019
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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