UniProtKB - Q94A40 (COPA1_ARATH)
Protein
Coatomer subunit alpha-1
Gene
At1g62020
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).By similarity
GO - Molecular functioni
- structural molecule activity Source: InterPro
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- intracellular protein transport Source: GO_Central
- intra-Golgi vesicle-mediated transport Source: GO_Central
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Coatomer subunit alpha-1Alternative name(s): Alpha-coat protein 1 Short name: Alpha-COP 1 |
Gene namesi | Ordered Locus Names:At1g62020 ORF Names:F8K4.21 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G62020 |
TAIRi | locus:2036823, AT1G62020 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Other locations
- Cytoplasm By similarity
- COPI-coated vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.By similarity
Cytosol
- cytosol Source: TAIR
Golgi apparatus
- COPI vesicle coat Source: GO_Central
- Golgi membrane Source: UniProtKB-SubCell
Nucleus
- nucleus Source: TAIR
Plasma Membrane
- plasma membrane Source: TAIR
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000285599 | 1 – 1216 | Coatomer subunit alpha-1Add BLAST | 1216 |
Proteomic databases
PaxDbi | Q94A40 |
PRIDEi | Q94A40 |
ProteomicsDBi | 242287 |
PTM databases
iPTMneti | Q94A40 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q94A40, baseline and differential |
Genevisiblei | Q94A40, AT |
Interactioni
Subunit structurei
Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
By similarityProtein-protein interaction databases
IntActi | Q94A40, 1 interactor |
STRINGi | 3702.AT1G62020.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 7 – 48 | WD 1Add BLAST | 42 | |
Repeati | 49 – 88 | WD 2Add BLAST | 40 | |
Repeati | 91 – 132 | WD 3Add BLAST | 42 | |
Repeati | 133 – 172 | WD 4Add BLAST | 40 | |
Repeati | 202 – 241 | WD 5Add BLAST | 40 | |
Repeati | 246 – 285 | WD 6Add BLAST | 40 | |
Repeati | 288 – 326 | WD 7Add BLAST | 39 | |
Repeati | 363 – 404 | WD 8Add BLAST | 42 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0292, Eukaryota |
HOGENOMi | CLU_007565_1_0_1 |
InParanoidi | Q94A40 |
OMAi | GNQVFCL |
OrthoDBi | 139008at2759 |
PhylomeDBi | Q94A40 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR024977, Apc4_WD40_dom IPR016391, Coatomer_asu IPR010714, Coatomer_asu_C IPR006692, Coatomer_WD-assoc_reg IPR020472, G-protein_beta_WD-40_rep IPR011048, Haem_d1_sf IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12894, ANAPC4_WD40, 1 hit PF04053, Coatomer_WDAD, 1 hit PF06957, COPI_C, 1 hit PF00400, WD40, 3 hits |
PIRSFi | PIRSF003354, Coatomer_alpha_subunit, 1 hit |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF51004, SSF51004, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
Q94A40-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTKFETKSN RVKGLSFHPK RPWILASLHS GVIQLWDYRM GTLIDRFDEH
60 70 80 90 100
EGPVRGVHFH NSQPLFVSGG DDYKIKVWNY KNHRCLFTLL GHLDYIRTVQ
110 120 130 140 150
FHHEYPWIVS ASDDQTIRIW NWQSRTCVSV LTGHNHYVMC ASFHPKEDLV
160 170 180 190 200
VSASLDQTVR VWDIGALRKK TVSPADDIMR LTQMNSDLFG GVDAIVKYVL
210 220 230 240 250
EGHDRGVNWA AFHPTLPLIV SGADDRQVKL WRMNETKAWE VDTLRGHMNN
260 270 280 290 300
VSSVMFHAKQ DIIVSNSEDK SIRVWDATKR TGLQTFRREH DRFWILAVHP
310 320 330 340 350
EMNLLAAGHD SGMIVFKLER ERPAFALSGD SLFYAKDRFL RYYEYSTQRD
360 370 380 390 400
SQVIPIRRPG TPSLNQSPRT LSYSPTENAV LICSDLDGGS YELYIIPKDS
410 420 430 440 450
VGRSDVVQDA KRGTGGSAVF IARNRFAVLE KSTSQVLVKN LKNEVVKKSP
460 470 480 490 500
LPIPTDAIFY AGTGNLLCRS EDKVVIFDLQ QRLVLGELQT PFVRYVVWSS
510 520 530 540 550
DMESVALLSK HTIIIASKKL VLQCTLHETI RVKSGAWDDN GVFIYTTLNH
560 570 580 590 600
IKYCLPNGDS GIIRTLDVPI YITKVSGNTI FCLDRDGKNK AITINATEYI
610 620 630 640 650
FKLSLLRKRY DHVMSMIKNS QLCGQAMIAY LQQKGFPEVA LHFVEDERIR
660 670 680 690 700
FNLALESGNI SVAVASATQI NEKDHWYRLG VEALRQGNSG IVEFAYQQTK
710 720 730 740 750
NFERLSFLYL ITGNLDKLSK LMKIAEVKNN VMGQFHNALY LGDVKERVKI
760 770 780 790 800
LENAGHLPLA YITASVHGLN DIAERLATEL GDNVPSLPEG KTPSLLMPPT
810 820 830 840 850
PIMCGGDWPL LRVMKGIFEG GLESADRGGT VDEEDVEGDW GEELDINVDG
860 870 880 890 900
MENRDIEDIL AAAEAGEEEN DEEGGWGLED LVLPPELDTP KASANARSSV
910 920 930 940 950
FVTPPQGMPV SQSWSQKSSL AAEQAAAGSF DTAMRLLHRQ LGIKNFTPLK
960 970 980 990 1000
SMFLDLFNGS HSYLRAFSSC PVVPLAIERG WSESSSPNVR SPPALVYDFS
1010 1020 1030 1040 1050
QLDEKLKSGY KATTTGKFTE ALRLFLSILH TIPLVVVETR REVDEVKELI
1060 1070 1080 1090 1100
VIVKEYVLGL QMELKRREMK DDPVRQQELA AYFTHCNLQT PHLRLALLSA
1110 1120 1130 1140 1150
MGVCYKAKNL ATASNFARRL LETSPVDSQA KMARQVVQAA ERNMTDETKL
1160 1170 1180 1190 1200
NYDFRNPFVV CGSTYVPIYR GQKDVSCPYC TARFVPNQEG NICTVCDLAV
1210
IGADASGLLC SPSQVR
Sequence cautioni
The sequence AAK91416 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAN46802 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004392 Genomic DNA Translation: AAC28519.1 CP002684 Genomic DNA Translation: AEE33914.1 AY050400 mRNA Translation: AAK91416.1 Different initiation. BT001048 mRNA Translation: AAN46802.1 Different initiation. |
PIRi | T02146 |
RefSeqi | NP_176393.1, NM_104882.5 |
Genome annotation databases
EnsemblPlantsi | AT1G62020.1; AT1G62020.1; AT1G62020 |
GeneIDi | 842497 |
Gramenei | AT1G62020.1; AT1G62020.1; AT1G62020 |
KEGGi | ath:AT1G62020 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004392 Genomic DNA Translation: AAC28519.1 CP002684 Genomic DNA Translation: AEE33914.1 AY050400 mRNA Translation: AAK91416.1 Different initiation. BT001048 mRNA Translation: AAN46802.1 Different initiation. |
PIRi | T02146 |
RefSeqi | NP_176393.1, NM_104882.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q94A40, 1 interactor |
STRINGi | 3702.AT1G62020.1 |
PTM databases
iPTMneti | Q94A40 |
Proteomic databases
PaxDbi | Q94A40 |
PRIDEi | Q94A40 |
ProteomicsDBi | 242287 |
Genome annotation databases
EnsemblPlantsi | AT1G62020.1; AT1G62020.1; AT1G62020 |
GeneIDi | 842497 |
Gramenei | AT1G62020.1; AT1G62020.1; AT1G62020 |
KEGGi | ath:AT1G62020 |
Organism-specific databases
Araporti | AT1G62020 |
TAIRi | locus:2036823, AT1G62020 |
Phylogenomic databases
eggNOGi | KOG0292, Eukaryota |
HOGENOMi | CLU_007565_1_0_1 |
InParanoidi | Q94A40 |
OMAi | GNQVFCL |
OrthoDBi | 139008at2759 |
PhylomeDBi | Q94A40 |
Miscellaneous databases
PROi | PR:Q94A40 |
Gene expression databases
ExpressionAtlasi | Q94A40, baseline and differential |
Genevisiblei | Q94A40, AT |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR024977, Apc4_WD40_dom IPR016391, Coatomer_asu IPR010714, Coatomer_asu_C IPR006692, Coatomer_WD-assoc_reg IPR020472, G-protein_beta_WD-40_rep IPR011048, Haem_d1_sf IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12894, ANAPC4_WD40, 1 hit PF04053, Coatomer_WDAD, 1 hit PF06957, COPI_C, 1 hit PF00400, WD40, 3 hits |
PIRSFi | PIRSF003354, Coatomer_alpha_subunit, 1 hit |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF51004, SSF51004, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COPA1_ARATH | |
Accessioni | Q94A40Primary (citable) accession number: Q94A40 Secondary accession number(s): O80706 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | May 1, 2007 | |
Last modified: | February 10, 2021 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names