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Protein

Tryptophan aminotransferase-related protein 2

Gene

TAR2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in auxin production. Both TAA1 and TAR2 are required for maintaining proper auxin levels in roots, while TAA1, TAR1 and TAR2 are required for proper embryo patterning. Involved in the maintenance of the root stem cell niches.1 Publication

Catalytic activityi

L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate.
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine.

Cofactori

pyridoxal 5'-phosphateBy similarity

Activity regulationi

Inhibited by L-kynurenine.1 Publication

Pathwayi: auxin biosynthesis

This protein is involved in the pathway auxin biosynthesis, which is part of Plant hormone metabolism.
View all proteins of this organism that are known to be involved in the pathway auxin biosynthesis and in Plant hormone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei112Pyridoxal phosphateBy similarity1
Binding sitei222Pyridoxal phosphateBy similarity1
Binding sitei276Pyridoxal phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAuxin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayi
UPA00151

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan aminotransferase-related protein 2 (EC:2.6.1.27, EC:2.6.1.99)
Gene namesi
Name:TAR2
Ordered Locus Names:At4g24670
ORF Names:F22K18.130
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G24670
TAIRilocus:2121999 AT4G24670

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 26HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004116751 – 440Tryptophan aminotransferase-related protein 2Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei268N6-(pyridoxal phosphate)lysineSequence analysis1

Proteomic databases

PaxDbiQ94A02
PRIDEiQ94A02

Expressioni

Tissue specificityi

Expressed in roots, cotyledons and in the apical parts of hypocotyls. In roots, restricted to the provasculature of meristematic regions. Detected on the inner side of the apical hooks.1 Publication

Developmental stagei

In early-stage flowers, expressed in all floral organs. Becomes later restricted to the gynoecia, preferentially to the outer cell layers that give rise to the valves. No expression in flowers at anthesis.1 Publication

Inductioni

Up-regulated by ethylene.1 Publication

Gene expression databases

ExpressionAtlasiQ94A02 baseline and differential
GenevisibleiQ94A02 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G24670.1

Structurei

3D structure databases

ProteinModelPortaliQ94A02
SMRiQ94A02
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni154 – 155Pyridoxal phosphate bindingBy similarity2
Regioni242 – 245Pyridoxal phosphate bindingBy similarity4
Regioni265 – 268Pyridoxal phosphate bindingBy similarity4

Sequence similaritiesi

Belongs to the alliinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHKQ Eukaryota
ENOG410YMNS LUCA
HOGENOMiHOG000237549
InParanoidiQ94A02
KOiK16903
OMAiGGILVHD
OrthoDBiEOG09360BJJ
PhylomeDBiQ94A02

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR006948 Alliinase_C
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF04864 Alliinase_C, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q94A02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQIPRFLSW RNMLVLSLAI NFSLILKILK GDRERGDSWD RTAYVSIWPV
60 70 80 90 100
VSTTASESSS LSSASCNYSK IEEDDDRIIN LKFGDPTVYE RYWQENGEVT
110 120 130 140 150
TMVIPGWQSL SYFSDENNLC WFLEPELAKE IVRVHKVVGN AVTQDRFIVV
160 170 180 190 200
GTGSTQLYQA ALYALSPHDD SGPINVVSAT PYYSTYPLIT DCLKSGLYRW
210 220 230 240 250
GGDAKTYKED GPYIELVTSP NNPDGFLRES VVNSTEGILI HDLAYYWPQY
260 270 280 290 300
TPITSPADHD VMLFTASKST GHAGIRIGWA LVKDRETARK MIEYIELNTI
310 320 330 340 350
GVSKDSQLRV AKVLKVVSDS CGNVTGKSFF DHSYDAMYER WKLLKQAAKD
360 370 380 390 400
TKRFSVPDFV SQRCNFFGRV FEPQPAFAWF KCEEGIVDCE KFLREEKKIL
410 420 430 440
TKSGKYFGDE LSNVRISMLD RDTNFNIFLH RITSSFNSTL
Length:440
Mass (Da):50,007
Last modified:December 1, 2001 - v1
Checksum:i1FED7264F48B1D87
GO

Sequence cautioni

The sequence CAA22996 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79377 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035356 Genomic DNA Translation: CAA22996.1 Sequence problems.
AL161561 Genomic DNA Translation: CAB79377.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE84940.1
CP002687 Genomic DNA Translation: AEE84941.1
AY050779 mRNA Translation: AAK92714.1
AY091455 mRNA Translation: AAM14394.1
PIRiT05567
RefSeqiNP_567706.1, NM_118600.2
NP_974608.1, NM_202879.2
UniGeneiAt.26567

Genome annotation databases

EnsemblPlantsiAT4G24670.1; AT4G24670.1; AT4G24670
AT4G24670.2; AT4G24670.2; AT4G24670
GeneIDi828569
GrameneiAT4G24670.1; AT4G24670.1; AT4G24670
AT4G24670.2; AT4G24670.2; AT4G24670
KEGGiath:AT4G24670

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035356 Genomic DNA Translation: CAA22996.1 Sequence problems.
AL161561 Genomic DNA Translation: CAB79377.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE84940.1
CP002687 Genomic DNA Translation: AEE84941.1
AY050779 mRNA Translation: AAK92714.1
AY091455 mRNA Translation: AAM14394.1
PIRiT05567
RefSeqiNP_567706.1, NM_118600.2
NP_974608.1, NM_202879.2
UniGeneiAt.26567

3D structure databases

ProteinModelPortaliQ94A02
SMRiQ94A02
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G24670.1

Proteomic databases

PaxDbiQ94A02
PRIDEiQ94A02

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G24670.1; AT4G24670.1; AT4G24670
AT4G24670.2; AT4G24670.2; AT4G24670
GeneIDi828569
GrameneiAT4G24670.1; AT4G24670.1; AT4G24670
AT4G24670.2; AT4G24670.2; AT4G24670
KEGGiath:AT4G24670

Organism-specific databases

AraportiAT4G24670
TAIRilocus:2121999 AT4G24670

Phylogenomic databases

eggNOGiENOG410IHKQ Eukaryota
ENOG410YMNS LUCA
HOGENOMiHOG000237549
InParanoidiQ94A02
KOiK16903
OMAiGGILVHD
OrthoDBiEOG09360BJJ
PhylomeDBiQ94A02

Enzyme and pathway databases

UniPathwayi
UPA00151

Miscellaneous databases

PROiPR:Q94A02

Gene expression databases

ExpressionAtlasiQ94A02 baseline and differential
GenevisibleiQ94A02 AT

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR006948 Alliinase_C
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF04864 Alliinase_C, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAR2_ARATH
AccessioniPrimary (citable) accession number: Q94A02
Secondary accession number(s): Q9SB62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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