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UniProtKB - Q949P1 (ABAH1_ARATH)
Protein
Abscisic acid 8'-hydroxylase 1
Gene
CYP707A1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Involved in the oxidative degradation of abscisic acid. Plays an important role in determining abscisic acid levels in dry seeds and in the control of postgermination growth.
3 PublicationsCatalytic activityi
- 2-cis-(+)-abscisate + O2 + reduced [NADPH—hemoprotein reductase] = (+)-8'-hydroxyabscisate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationEC:1.14.14.1371 Publication
Cofactori
hemeBy similarity
: abscisic acid degradation Pathwayi
This protein is involved in the pathway abscisic acid degradation, which is part of Plant hormone degradation.View all proteins of this organism that are known to be involved in the pathway abscisic acid degradation and in Plant hormone degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 411 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- (+)-abscisic acid 8'-hydroxylase activity Source: GO_Central
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: GO_Central
- oxidoreductase activity Source: GO_Central
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Source: GO_Central
GO - Biological processi
- abscisic acid catabolic process Source: UniProtKB-UniPathway
- abscisic acid metabolic process Source: GO_Central
- sterol metabolic process Source: GO_Central
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Stress response |
Ligand | Heme, Iron, Metal-binding, NADP |
Enzyme and pathway databases
BioCyci | ARA:AT4G19230-MONOMER |
BRENDAi | 1.14.14.137, 399 |
UniPathwayi | UPA00093 |
Names & Taxonomyi
Protein namesi | Recommended name: Abscisic acid 8'-hydroxylase 1 (EC:1.14.14.1371 Publication)Short name: ABA 8'-hydroxylase 1 Alternative name(s): Cytochrome P450 707A1 |
Gene namesi | Name:CYP707A1 Ordered Locus Names:At4g19230 ORF Names:T18B16.200 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT4G19230 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 5 – 24 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Disruption phenotypei
Plants show a reduced germination.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288639 | 1 – 467 | Abscisic acid 8'-hydroxylase 1Add BLAST | 467 |
Expressioni
Tissue specificityi
Mainly expressed in flowers, siliques, roots and stems. Lower expression in rosette leaves and dry seeds. Expressed in vascular tissues of embryo during the seed development.3 Publications
Developmental stagei
Expressed predominantly during mid-maturation of seed and down-regulated during late maturation. Up-regulated 12 hours after seed imbibition.2 Publications
Inductioni
By abscisic acid treatment, salt or osmotic stresses, and by dehydration and rehydration. Expression regulated by phytochrome B.3 Publications
Gene expression databases
ExpressionAtlasi | Q949P1, baseline and differential |
Genevisiblei | Q949P1, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 12956, 1 interactor |
STRINGi | 3702.AT4G19230.2 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0157, Eukaryota |
HOGENOMi | CLU_001570_15_5_1 |
OMAi | AHMCLGL |
PhylomeDBi | Q949P1 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry describes 1 produced by isoform ialternative splicing. AlignAdd to basketNote: A number of isoforms are produced. According to EST sequences.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q949P1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDISALFLTL FAGSLFLYFL RCLISQRRFG SSKLPLPPGT MGWPYVGETF
60 70 80 90 100
QLYSQDPNVF FQSKQKRYGS VFKTHVLGCP CVMISSPEAA KFVLVTKSHL
110 120 130 140 150
FKPTFPASKE RMLGKQAIFF HQGDYHAKLR KLVLRAFMPE SIRNMVPDIE
160 170 180 190 200
SIAQDSLRSW EGTMINTYQE MKTYTFNVAL LSIFGKDEVL YREDLKRCYY
210 220 230 240 250
ILEKGYNSMP VNLPGTLFHK SMKARKELSQ ILARILSERR QNGSSHNDLL
260 270 280 290 300
GSFMGDKEEL TDEQIADNII GVIFAARDTT ASVMSWILKY LAENPNVLEA
310 320 330 340 350
VTEEQMAIRK DKEEGESLTW GDTKKMPLTS RVIQETLRVA SILSFTFREA
360 370 380 390 400
VEDVEYEGYL IPKGWKVLPL FRNIHHSADI FSNPGKFDPS RFEVAPKPNT
410 420 430 440 450
FMPFGNGTHS CPGNELAKLE MSIMIHHLTT KYSWSIVGAS DGIQYGPFAL
460
PQNGLPIVLA RKPEIEV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA8MRX5 | A8MRX5_ARATH | Cytochrome P450, family 707, subfam... | CYP707A1 ''cytochrome P450, cytochrome P450, family 707, polypeptide 1, polypeptide 1'' | 484 | Annotation score: |
Sequence cautioni
The sequence CAA16713 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB78925 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB122149 mRNA Translation: BAD16629.1 AL021687 Genomic DNA Translation: CAA16713.1 Sequence problems. AL161550 Genomic DNA Translation: CAB78925.1 Sequence problems. CP002687 Genomic DNA Translation: AEE84162.1 AY050980 mRNA Translation: AAK93657.1 AY091446 mRNA Translation: AAM14385.1 |
PIRi | T04444 |
RefSeqi | NP_567581.1, NM_118043.2 [Q949P1-1] |
Genome annotation databases
EnsemblPlantsi | AT4G19230.1; AT4G19230.1; AT4G19230 [Q949P1-1] |
GeneIDi | 827663 |
Gramenei | AT4G19230.1; AT4G19230.1; AT4G19230 [Q949P1-1] |
KEGGi | ath:AT4G19230 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB122149 mRNA Translation: BAD16629.1 AL021687 Genomic DNA Translation: CAA16713.1 Sequence problems. AL161550 Genomic DNA Translation: CAB78925.1 Sequence problems. CP002687 Genomic DNA Translation: AEE84162.1 AY050980 mRNA Translation: AAK93657.1 AY091446 mRNA Translation: AAM14385.1 |
PIRi | T04444 |
RefSeqi | NP_567581.1, NM_118043.2 [Q949P1-1] |
3D structure databases
SMRi | Q949P1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 12956, 1 interactor |
STRINGi | 3702.AT4G19230.2 |
Genome annotation databases
EnsemblPlantsi | AT4G19230.1; AT4G19230.1; AT4G19230 [Q949P1-1] |
GeneIDi | 827663 |
Gramenei | AT4G19230.1; AT4G19230.1; AT4G19230 [Q949P1-1] |
KEGGi | ath:AT4G19230 |
Organism-specific databases
Araporti | AT4G19230 |
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
HOGENOMi | CLU_001570_15_5_1 |
OMAi | AHMCLGL |
PhylomeDBi | Q949P1 |
Enzyme and pathway databases
UniPathwayi | UPA00093 |
BioCyci | ARA:AT4G19230-MONOMER |
BRENDAi | 1.14.14.137, 399 |
Miscellaneous databases
PROi | PR:Q949P1 |
Gene expression databases
ExpressionAtlasi | Q949P1, baseline and differential |
Genevisiblei | Q949P1, AT |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ABAH1_ARATH | |
Accessioni | Q949P1Primary (citable) accession number: Q949P1 Secondary accession number(s): O65624 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families