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UniProtKB - Q949M8 (3HID3_ARATH)
Protein
Probable 3-hydroxyisobutyrate dehydrogenase-like 3, mitochondrial
Gene
At1g71180
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Catalytic activityi
- EC:1.1.1.31
: L-valine degradation Pathwayi
This protein is involved in the pathway L-valine degradation, which is part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the pathway L-valine degradation and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 129 | NAD; via amide nitrogenBy similarity | 1 | |
Active sitei | 203 | By similarity | 1 | |
Binding sitei | 271 | NADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 35 – 64 | NADBy similarityAdd BLAST | 30 |
GO - Molecular functioni
- 3-hydroxyisobutyrate dehydrogenase activity Source: UniProtKB-EC
- NAD binding Source: InterPro
- NADP binding Source: InterPro
GO - Biological processi
- valine catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Branched-chain amino acid catabolism |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | ARA:AT1G71180-MONOMER |
UniPathwayi | UPA00362 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable 3-hydroxyisobutyrate dehydrogenase-like 3, mitochondrial (EC:1.1.1.31)Short name: HIBADH-like |
Gene namesi | Ordered Locus Names:At1g71180 ORF Names:F23N20.17 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G71180 |
TAIRi | locus:2026351, AT1G71180 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000421119 | 1 – 318 | Probable 3-hydroxyisobutyrate dehydrogenase-like 3, mitochondrialAdd BLAST | 318 |
Proteomic databases
PaxDbi | Q949M8 |
ProteomicsDBi | 245156 |
PTM databases
iPTMneti | Q949M8 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q949M8, baseline and differential |
Genevisiblei | Q949M8, AT |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0409, Eukaryota |
HOGENOMi | CLU_035117_1_0_1 |
InParanoidi | Q949M8 |
OMAi | NALGCEY |
OrthoDBi | 812358at2759 |
PhylomeDBi | Q949M8 |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006115, 6PGDH_NADP-bd IPR015815, HIBADH-related IPR036291, NAD(P)-bd_dom_sf IPR029154, NADP-bd |
Pfami | View protein in Pfam PF14833, NAD_binding_11, 1 hit PF03446, NAD_binding_2, 1 hit |
PIRSFi | PIRSF000103, HIBADH, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
Q949M8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFYQSSSSLT QILHSFCGNT EMETPYPKLI DPSKTRIGWI GIGIMGSAMV
60 70 80 90 100
SHIIAAGYSV TVYARDLRKT KDLQTKGARI ANSPKELAEM SDVVFTIVGN
110 120 130 140 150
FNDVRSLLLG DDGVLSGLTP GGVTVDMTSS KPGLAREIHA EARRRNCWAV
160 170 180 190 200
DAPVSGGDAG AREGTLGIFA GGDSEIVEWL SPVMKNIGTV TYMGEAGSGQ
210 220 230 240 250
SCKIGNQIAG ASNLVGLAEG IVFAEKAGLD TVKWLEAVKD GAAGSAVMRL
260 270 280 290 300
FGEMIVKRDY RATGFAEYMV KDLGMAAEAA MPGAALSKQL FTGMVANGDG
310
KLGIQGVVSV IRRLNGIS
Sequence cautioni
The sequence AAG51699 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC016972 Genomic DNA Translation: AAG51699.1 Different initiation. CP002684 Genomic DNA Translation: AEE35169.1 AY051005 mRNA Translation: AAK93682.1 AY113980 mRNA Translation: AAM45028.1 |
PIRi | E96736 |
RefSeqi | NP_565014.1, NM_105787.2 |
Genome annotation databases
EnsemblPlantsi | AT1G71180.1; AT1G71180.1; AT1G71180 |
GeneIDi | 843458 |
Gramenei | AT1G71180.1; AT1G71180.1; AT1G71180 |
KEGGi | ath:AT1G71180 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC016972 Genomic DNA Translation: AAG51699.1 Different initiation. CP002684 Genomic DNA Translation: AEE35169.1 AY051005 mRNA Translation: AAK93682.1 AY113980 mRNA Translation: AAM45028.1 |
PIRi | E96736 |
RefSeqi | NP_565014.1, NM_105787.2 |
3D structure databases
SMRi | Q949M8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT1G71180.1 |
PTM databases
iPTMneti | Q949M8 |
Proteomic databases
PaxDbi | Q949M8 |
ProteomicsDBi | 245156 |
Genome annotation databases
EnsemblPlantsi | AT1G71180.1; AT1G71180.1; AT1G71180 |
GeneIDi | 843458 |
Gramenei | AT1G71180.1; AT1G71180.1; AT1G71180 |
KEGGi | ath:AT1G71180 |
Organism-specific databases
Araporti | AT1G71180 |
TAIRi | locus:2026351, AT1G71180 |
Phylogenomic databases
eggNOGi | KOG0409, Eukaryota |
HOGENOMi | CLU_035117_1_0_1 |
InParanoidi | Q949M8 |
OMAi | NALGCEY |
OrthoDBi | 812358at2759 |
PhylomeDBi | Q949M8 |
Enzyme and pathway databases
UniPathwayi | UPA00362 |
BioCyci | ARA:AT1G71180-MONOMER |
Miscellaneous databases
PROi | PR:Q949M8 |
Gene expression databases
ExpressionAtlasi | Q949M8, baseline and differential |
Genevisiblei | Q949M8, AT |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006115, 6PGDH_NADP-bd IPR015815, HIBADH-related IPR036291, NAD(P)-bd_dom_sf IPR029154, NADP-bd |
Pfami | View protein in Pfam PF14833, NAD_binding_11, 1 hit PF03446, NAD_binding_2, 1 hit |
PIRSFi | PIRSF000103, HIBADH, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 3HID3_ARATH | |
Accessioni | Q949M8Primary (citable) accession number: Q949M8 Secondary accession number(s): Q9C990 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2013 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families