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UniProtKB - Q949G3 (PDR1_NICPL)

Entry version 87 (25 May 2022)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Pleiotropic drug resistance protein 1

Gene

PDR1

Organism
Nicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Excretes secondary metabolites such as terpenes. Involved in both constitutive and jasmonic acid-dependent induced defense. Confers some resistance to sclareol and B.cinerea.

2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi198 – 205ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi883 – 890ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPlant defense, Transport
LigandATP-binding, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.1.205.21, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleiotropic drug resistance protein 1
Alternative name(s):
NpPDR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDR1
Synonyms:ABC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4092 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › lamiids › Solanales › Solanaceae › Nicotianoideae › Nicotianeae › Nicotiana

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei534 – 554HelicalSequence analysisAdd BLAST21
Transmembranei567 – 587HelicalSequence analysisAdd BLAST21
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Transmembranei653 – 673HelicalSequence analysisAdd BLAST21
Transmembranei679 – 699HelicalSequence analysisAdd BLAST21
Transmembranei707 – 727HelicalSequence analysisAdd BLAST21
Transmembranei764 – 784HelicalSequence analysisAdd BLAST21
Transmembranei1184 – 1204HelicalSequence analysisAdd BLAST21
Transmembranei1214 – 1234HelicalSequence analysisAdd BLAST21
Transmembranei1270 – 1290HelicalSequence analysisAdd BLAST21
Transmembranei1301 – 1321HelicalSequence analysisAdd BLAST21
Transmembranei1327 – 1347HelicalSequence analysisAdd BLAST21
Transmembranei1358 – 1378HelicalSequence analysisAdd BLAST21
Transmembranei1408 – 1428HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002346531 – 1436Pleiotropic drug resistance protein 1Add BLAST1436

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q949G3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Roots, petals and leaf epidermis, where it is confined to glandular trichomes (at protein level).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By terpenes such as sclareolide and sclareol, and by some phytohormones such as jasmonic acid (JA) and ethylene. Strongly induced by compatible pathogens such as the fungus B.cinerea, and the bacteria P.syringae pv tabaci, as well as by non pathogenic bacteria such as P.fluorescens, and P.marginalis pv marginalis. Weak induction by incompatible pathogens such as P.syringae pv syringae (at protein level).3 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q949G3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q949G3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini165 – 438ABC transporter 1PROSITE-ProRule annotationAdd BLAST274
Domaini516 – 729ABC transmembrane type-2 1Add BLAST214
Domaini838 – 1090ABC transporter 2PROSITE-ProRule annotationAdd BLAST253
Domaini1163 – 1377ABC transmembrane type-2 2Add BLAST215

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni796 – 826DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi796 – 819Polar residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Conserved Domains Database

More...CDDi		cd03233, ABCG_PDR_domain1, 1 hit
cd03232, ABCG_PDR_domain2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR029481, ABC_trans_N
IPR003439, ABC_transporter-like_ATP-bd
IPR043926, ABCG_dom
IPR034001, ABCG_PDR_1
IPR034003, ABCG_PDR_2
IPR027417, P-loop_NTPase
IPR013581, PDR_assoc

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01061, ABC2_membrane, 2 hits
PF19055, ABC2_membrane_7, 1 hit
PF00005, ABC_tran, 2 hits
PF14510, ABC_trans_N, 1 hit
PF08370, PDR_assoc, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q949G3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPADLSNLR GRSLRASIRG SMRGSIRENS NSIWRNNGAE VFSRSARDED 
        60         70         80         90        100
DEEALKWAAL EKLPTYDRLR KGILFGSQGA AAEVDVDDSG VLERKNLLER 
       110        120        130        140        150
LVKVADEDNE KFLLKLKNRI DRVGIDFPSI EVRFEHLNID ADAYVGSRAL 
       160        170        180        190        200
PTFTNFISNF VEGLLDSIHI LPSKKRQVTI LKDVSGIVKP CRMTLLLGPP 
       210        220        230        240        250
GSGKTTLLLA LAGKLDSALK VTGKVTYNGH ELHEFVPQRT AAYISQHDLH 
       260        270        280        290        300
IGEMTVRETL EFSARCQGVG SRYEMLAELS RREKAANIKP DADIDMFMKA 
       310        320        330        340        350
ASTEGQEAKV VTDYILKILG LDICADTMVG DQMIRGISGG QKKRVTTGEM 
       360        370        380        390        400
IVGPSKALFM DEISTGLDSS TTYSIVNSLK QSVRIMKGTA LISLLQPAPE 
       410        420        430        440        450
TYNLFDDIIL LSDGYIVYEG PREEVLEFFE SMGFKCPERK GAADFLQEVT 
       460        470        480        490        500
SKKDQQQYWI RRDEPYRFIT SKEFAEAYQS FHVGRKVSDE LKTTFDKSKS 
       510        520        530        540        550
HPAALTTQKY GIGKRQLLKV CTERELLLMQ RNSFVYLFKF FQLLIIALMT 
       560        570        580        590        600
MTIFFRTKMP RDSAEDGGIY SGALFFVVIM IMFNGLSELP MTLYKLPVFY 
       610        620        630        640        650
KQRDFLFYPS WAYAIPSWIL KIPVTFAEVG MWVFLTYYVM GFDPNVGRFF 
       660        670        680        690        700
KQFLLLLLVN QMASALFRFI AAVGRTMGVA STFGAFALLL QFALGGFILA 
       710        720        730        740        750
RNDVKDWWIW GYWTSPLMYS VNAILVNEFD GQKWKHIVAG GTEPLGAAVV 
       760        770        780        790        800
RARGFFPDAY WYWIGVGALA GFIVMFNIAY SVALAYLNPF DKPQATISDE 
       810        820        830        840        850
SENNESESSP QITSTQEGDS ASENKKKGMV LPFDPHSITF DEVVYSVDMP 
       860        870        880        890        900
PEMRESGTSD NRLVLLKSVS GAFRPGVLTA LMGVSGAGKT TLMDVLAGRK 
       910        920        930        940        950
TGGYIDGSIK ISGYPKKQDT FARISGYCEQ NDIHSPYVTV FESLVYSAWL 
       960        970        980        990       1000
RLPQDVNEEK RMMFVEEVMD LVELTPLRSA LVGLPGVNGL STEQRKRLTI 
      1010       1020       1030       1040       1050
AVELVANPSI IFMDEPTSGL DARAAAIVMR AVRNTVDTGR TVVCTIHQPS 
      1060       1070       1080       1090       1100
IDIFEAFDEL FLMKRGGQEI YVGPLGRQSC HLIKYFESIP GVSKIVEGYN 
      1110       1120       1130       1140       1150
PATWMLEVTA SSQEMALGVD FTDLYKKSDL YRRNKALIDE LSVPRPGTSD 
      1160       1170       1180       1190       1200
LHFDSEFSQP FWTQCMACLW KQHWSYWRNP AYTAVRLIFT TFIALIFGTM 
      1210       1220       1230       1240       1250
FWDIGTKVSR NQDLVNAMGS MYAAVLFLGV QNSSSVQPVV SVERTVFYRE 
      1260       1270       1280       1290       1300
KAAGMYSAIP YAFAQVLIEI PYIFVQATVY GLIVYSMIGF EWTVAKFFWD 
      1310       1320       1330       1340       1350
FFFMFFTFLY FTFFGMMTVA VTPNQNVASI VAGFFYTVWN LFSGFIVPRP 
      1360       1370       1380       1390       1400
RIPIWWRWYY WGCPIAWTLY GLVASQFGDL QDPLTDQNQT VEQFLRSNFG 
      1410       1420       1430 
FKHDFLGVVA AVIVAFAVVF AFTFALGIKA FNFQRR
Length:1,436
Mass (Da):161,849
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0337AB7941B2EC03
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ404328 mRNA Translation: CAC40990.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404328 mRNA Translation: CAC40990.1

3D structure databases

AlphaFoldDBiQ949G3
SMRiQ949G3
ModBaseiSearch...

Protein family/group databases

TCDBi3.A.1.205.21, the atp-binding cassette (abc) superfamily

Proteomic databases

PRIDEiQ949G3

Family and domain databases

CDDicd03233, ABCG_PDR_domain1, 1 hit
cd03232, ABCG_PDR_domain2, 1 hit
Gene3Di3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR029481, ABC_trans_N
IPR003439, ABC_transporter-like_ATP-bd
IPR043926, ABCG_dom
IPR034001, ABCG_PDR_1
IPR034003, ABCG_PDR_2
IPR027417, P-loop_NTPase
IPR013581, PDR_assoc
PfamiView protein in Pfam
PF01061, ABC2_membrane, 2 hits
PF19055, ABC2_membrane_7, 1 hit
PF00005, ABC_tran, 2 hits
PF14510, ABC_trans_N, 1 hit
PF08370, PDR_assoc, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDR1_NICPL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q949G3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: May 25, 2022
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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