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Entry version 162 (07 Apr 2021)
Sequence version 3 (23 Jan 2007)
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Protein

Voltage-dependent anion-selective channel

Gene

porin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms a channel through the mitochondrial outer membrane and also the plasma membrane (By similarity). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (By similarity). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). In depolarized mitochondria, acts downstream of park to promote mitophagy or prevent apoptosis; polyubiquitination by park promotes mitophagy, while monoubiquitination by park decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei72Involved in hexokinase bindingBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionPorin
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-5205685, PINK1-PRKN Mediated Mitophagy
R-DME-5689880, Ub-specific processing proteases
R-DME-70268, Pyruvate metabolism

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.B.8.1.6, the mitochondrial and plastid porin (mpp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent anion-selective channel
Alternative name(s):
DmVDAC
Porin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:porin
Synonyms:POR-1, VDAC
ORF Names:CG6647
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004363, porin

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi11K → R: Poly-KR; increase in apoptosis when overexpressed in muscle cells, resulting in wing posture abnormalities; when associated with R-19, R-52 and R-109. 1 Publication1
Mutagenesisi19K → R: Poly-KR; increase in apoptosis when overexpressed in muscle cells, resulting in wing posture abnormalities; when associated with R-11, R-52 and R-109. 1 Publication1
Mutagenesisi52K → R: Poly-KR; increase in apoptosis when overexpressed in muscle cells, resulting in wing posture abnormalities; when associated with R-11, R-19 and R-109. 1 Publication1
Mutagenesisi109K → R: Poly-KR; increase in apoptosis when overexpressed in muscle cells, resulting in wing posture abnormalities; when associated with R-11, R-19 and R-52. 1 Publication1
Mutagenesisi273K → R: Significant increase in apoptosis when overexpressed in muscle cells, resulting in severe wing posture abnormalities and impaired climbing ability. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000505202 – 282Voltage-dependent anion-selective channelAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki19Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki273Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated (PubMed:32047033). Undergoes monoubiquitination and polyubiquitination by park; monoubiquitination at Lys-273 inhibits apoptosis, whereas polyubiquitination at Lys-11, Lys-19, Lys-52 and Lys-109 may promote mitophagy (PubMed:32047033).1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q94920

PRoteomics IDEntifications database

More...
PRIDEi
Q94920

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout development, highest levels are in embryos and pupae.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004363, Expressed in second segment of antenna (Drosophila) and 71 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q94920, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q94920, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hexokinases.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
60572, 77 interactors

Database of interacting proteins

More...
DIPi
DIP-17501N

Protein interaction database and analysis system

More...
IntActi
Q94920, 5 interactors

Molecular INTeraction database

More...
MINTi
Q94920

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0079772

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q94920

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists mainly of membrane-spanning sided beta-sheets.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3126, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182869

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_044399_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q94920

Identification of Orthologs from Complete Genome Data

More...
OMAi
WDSKAGN

Database of Orthologous Groups

More...
OrthoDBi
938262at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q94920

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07306, Porin3_VDAC, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.160.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023614, Porin_dom_sf
IPR001925, Porin_Euk
IPR027246, Porin_Euk/Tom40
IPR030277, VDAC2

The PANTHER Classification System

More...
PANTHERi
PTHR11743, PTHR11743, 1 hit
PTHR11743:SF12, PTHR11743:SF12, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01459, Porin_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00185, EUKARYTPORIN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00558, EUKARYOTIC_PORIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q94920-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPPSYSDLG KQARDIFSKG YNFGLWKLDL KTKTSSGIEF NTAGHSNQES
60 70 80 90 100
GKVFGSLETK YKVKDYGLTL TEKWNTDNTL FTEVAVQDQL LEGLKLSLEG
110 120 130 140 150
NFAPQSGNKN GKFKVAYGHE NVKADSDVNI DLKGPLINAS AVLGYQGWLA
160 170 180 190 200
GYQTAFDTQQ SKLTTNNFAL GYTTKDFVLH TAVNDGQEFS GSIFQRTSDK
210 220 230 240 250
LDVGVQLSWA SGTSNTKFAI GAKYQLDDDA SVRAKVNNAS QVGLGYQQKL
260 270 280
RDGVTLTLST LVDGKNFNAG GHKIGVGLEL EA
Length:282
Mass (Da):30,550
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i173E165C3A2D297D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PD75M9PD75_DROME
Porin, isoform D
porin anon-WO02059370.56, cg6647, Dmel\CG6647, DmPorin1, DmVDAC
282Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti231S → R in CAA63143 (PubMed:8797793).Curated1
Sequence conflicti231S → R in CAA64988 (PubMed:9688565).Curated1
Sequence conflicti252D → T in CAA63143 (PubMed:8797793).Curated1
Sequence conflicti252D → T in CAA64988 (PubMed:9688565).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U70314 mRNA Translation: AAC02635.1
X92408 mRNA Translation: CAA63143.1
X95692 mRNA Translation: CAA64988.1
AJ000880 Genomic DNA Translation: CAA04370.1
AE014134 Genomic DNA Translation: AAF53022.1
AE014134 Genomic DNA Translation: AAN10766.1
AE014134 Genomic DNA Translation: ABC65894.1
AY070509 mRNA Translation: AAL47980.1
BT024247 mRNA Translation: ABC86309.1

NCBI Reference Sequences

More...
RefSeqi
NP_001033899.1, NM_001038810.2
NP_001245961.1, NM_001259032.1
NP_001260365.1, NM_001273436.1
NP_476813.1, NM_057465.4
NP_599110.1, NM_134283.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0080182; FBpp0079771; FBgn0004363
FBtr0080183; FBpp0079772; FBgn0004363
FBtr0100584; FBpp0100039; FBgn0004363
FBtr0305260; FBpp0293784; FBgn0004363
FBtr0332029; FBpp0304343; FBgn0004363

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34500

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6647

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70314 mRNA Translation: AAC02635.1
X92408 mRNA Translation: CAA63143.1
X95692 mRNA Translation: CAA64988.1
AJ000880 Genomic DNA Translation: CAA04370.1
AE014134 Genomic DNA Translation: AAF53022.1
AE014134 Genomic DNA Translation: AAN10766.1
AE014134 Genomic DNA Translation: ABC65894.1
AY070509 mRNA Translation: AAL47980.1
BT024247 mRNA Translation: ABC86309.1
RefSeqiNP_001033899.1, NM_001038810.2
NP_001245961.1, NM_001259032.1
NP_001260365.1, NM_001273436.1
NP_476813.1, NM_057465.4
NP_599110.1, NM_134283.2

3D structure databases

SMRiQ94920
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi60572, 77 interactors
DIPiDIP-17501N
IntActiQ94920, 5 interactors
MINTiQ94920
STRINGi7227.FBpp0079772

Protein family/group databases

TCDBi1.B.8.1.6, the mitochondrial and plastid porin (mpp) family

Proteomic databases

PaxDbiQ94920
PRIDEiQ94920

Genome annotation databases

EnsemblMetazoaiFBtr0080182; FBpp0079771; FBgn0004363
FBtr0080183; FBpp0079772; FBgn0004363
FBtr0100584; FBpp0100039; FBgn0004363
FBtr0305260; FBpp0293784; FBgn0004363
FBtr0332029; FBpp0304343; FBgn0004363
GeneIDi34500
KEGGidme:Dmel_CG6647

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
34500
FlyBaseiFBgn0004363, porin

Phylogenomic databases

eggNOGiKOG3126, Eukaryota
GeneTreeiENSGT00950000182869
HOGENOMiCLU_044399_2_0_1
InParanoidiQ94920
OMAiWDSKAGN
OrthoDBi938262at2759
PhylomeDBiQ94920

Enzyme and pathway databases

ReactomeiR-DME-5205685, PINK1-PRKN Mediated Mitophagy
R-DME-5689880, Ub-specific processing proteases
R-DME-70268, Pyruvate metabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
34500, 1 hit in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
porin, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34500

Protein Ontology

More...
PROi
PR:Q94920

Gene expression databases

BgeeiFBgn0004363, Expressed in second segment of antenna (Drosophila) and 71 other tissues
ExpressionAtlasiQ94920, baseline and differential
GenevisibleiQ94920, DM

Family and domain databases

CDDicd07306, Porin3_VDAC, 1 hit
Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614, Porin_dom_sf
IPR001925, Porin_Euk
IPR027246, Porin_Euk/Tom40
IPR030277, VDAC2
PANTHERiPTHR11743, PTHR11743, 1 hit
PTHR11743:SF12, PTHR11743:SF12, 1 hit
PfamiView protein in Pfam
PF01459, Porin_3, 1 hit
PRINTSiPR00185, EUKARYTPORIN
PROSITEiView protein in PROSITE
PS00558, EUKARYOTIC_PORIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVDAC_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94920
Secondary accession number(s): Q29QZ3, Q94997, Q9VKP1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: April 7, 2021
This is version 162 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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