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Protein

T-complex protein 1 subunit alpha

Gene

TCP-1A

Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit alpha
Short name:
TCP-1-alpha
Alternative name(s):
CCT-alpha
Gene namesi
Name:TCP-1A
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283111 – 545T-complex protein 1 subunit alphaAdd BLAST545

Proteomic databases

PRIDEiQ94757

Expressioni

Gene expression databases

ExpressionAtlasiQ94757 baseline

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ94757
SMRiQ94757
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0360 Eukaryota
COG0459 LUCA
OrthoDBiEOG091G04HL

Family and domain databases

CDDicd03335 TCP1_alpha, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012715 Chap_CCT_alpha
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02340 chap_CCT_alpha, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q94757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLGGERTS GESVRKQNVL AACSFANFVK TSLGPVGLDK MLVDDVGDVT
60 70 80 90 100
ITNDGATILK LLDVEHPAAK ILVQLAQLQD EEVGDGTTSV VILAAALLKN
110 120 130 140 150
ADELISRFVH PTTVINGYRL ACREACKYIQ EHMAYDVNKL GKAGLINVAR
160 170 180 190 200
TAMSSKLINL DADMFSQMAV DALMAVEVSG GPKGPVYPIK AVNILKAHGR
210 220 230 240 250
SMSESMLIDG YALNCTAASQ QMPRIIKKAK IAFLDFSLQK VKMKLGVQVV
260 270 280 290 300
VKDPAQLEAI RQREADITKE RIQKILNAGA NVILTTGGID DLCMKYFVEV
310 320 330 340 350
NAMAVRRCKK VDLKNMAKAT GGQLIVSLAD MEGDEVFDPT KLGNAEEVSQ
360 370 380 390 400
ERICDDELII LRGPKVHPSA SIILRGANDF YVDEMERSLH DALLVVKRVL
410 420 430 440 450
ESKRIVPGAG ACETAVSIYL ENYALTLSSR EQLAIAEFAR AMLSIPKQLA
460 470 480 490 500
VNAGVDSTEL VARLRSCHNS SQSKPDQAHN KWWGLDLNNQ YVADCKEIGV
510 520 530 540
FEPLVSKIKS LKFATEAAIT ILRIDDLIKL KEEKQPDHDG DECGY
Length:545
Mass (Da):59,440
Last modified:February 1, 1997 - v1
Checksum:i992CCA919389E42C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55769 mRNA Translation: AAA99815.1

Similar proteinsi

Entry informationi

Entry nameiTCPA_SCHMA
AccessioniPrimary (citable) accession number: Q94757
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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