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Entry version 178 (17 Jun 2020)
Sequence version 1 (01 Feb 1997)
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Protein

Nuclear factor NF-kappa-B p110 subunit

Gene

Rel

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a key role in the humoral immune response (PubMed:8816802, PubMed:10619029, PubMed:11269501, PubMed:11872802, PubMed:22022271). Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes (PubMed:11269501). I-kappa-B kinase complex (IKKbeta and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation (PubMed:11872802, PubMed:11018014). Part of a Toll-related receptor pathway that functions in the apoptosis of unfit cells during cell competition (PubMed:25477468). May be part of a NF-kappa-B and Tollo signaling cascade that regulates development of the peripheral nervous system (PubMed:18000549). Possibly post-transcriptionally regulates the neuron-specific genes sc and ase, by promoting the rapid turnover of their transcripts in the wing imaginal disk (PubMed:18000549).7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processImmunity, Innate immunity, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1169091 Activation of NF-kappaB in B cells
R-DME-1810476 RIP-mediated NFkB activation via ZBP1
R-DME-202424 Downstream TCR signaling
R-DME-209394 Transcriptional activtion and repression of REL-68 target genes
R-DME-209560 NF-kB is activated and signals survival
R-DME-214399 Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214411 REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214416 Phosphorylated REL is cleaved by and dissociates from DREDD
R-DME-2871837 FCERI mediated NF-kB activation
R-DME-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-DME-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-DME-4755510 SUMOylation of immune response proteins
R-DME-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-5621575 CD209 (DC-SIGN) signaling
R-DME-5676590 NIK-->noncanonical NF-kB signaling
R-DME-6798695 Neutrophil degranulation
R-DME-9020702 Interleukin-1 signaling
R-DME-933542 TRAF6 mediated NF-kB activation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q94527

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear factor NF-kappa-B p110 subunit
Alternative name(s):
Rel-p110
Relish protein
Cleaved into the following 2 chains:
Alternative name(s):
Rel-p68
Alternative name(s):
Rel-p49
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RelImported
ORF Names:CG11992Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0014018 Rel

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Larvae infected with Gram-negative bacteria fail to activate tracheal expression of the antibacterial peptide gene Drs (PubMed:22022271). Ectopic bristles develop on the dorsocentral, scutellar and lateral regions of the noctum, with one or more ectopic bristles per hemi-notum (PubMed:18000549).

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi545D → A: Completely resistant to cleavage. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000303181 – 971Nuclear factor NF-kappa-B p110 subunit1 PublicationAdd BLAST971
ChainiPRO_00000303191 – 545Nuclear factor NF-kappa-B p68 subunit1 PublicationAdd BLAST545
ChainiPRO_0000030320546 – 971Nuclear factor NF-kappa-B p49 subunit1 PublicationAdd BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei431Phosphoserine; by PKASequence analysis1
Modified residuei620Phosphothreonine1 Publication1
Modified residuei626Phosphotyrosine1 Publication1
Modified residuei950PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by lipopolysaccharide (LPS)-activated I-kappa-B kinase complex before being cleaved. Rel-p110 subunit is cleaved within seconds of an immune challenge into Rel-p49 subunit and Rel-p68 subunit. Rel-p110 subunit reappears after 45 minutes.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei545 – 546Cleavage (when cotranslationally processed)1 Publication2

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q94527

PRoteomics IDEntifications database

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PRIDEi
Q94527

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q94527

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By bacteria and fungi.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0014018 Expressed in embryonic/larval hemocyte (Drosophila) and 51 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q94527 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q94527 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Rel-p68 subunit interacts with Dredd (PubMed:11269502).

Interacts with DMAP1 (PubMed:24947515).

Interacts with akirin; interaction is immune stimulation-dependent; activates selected rel target gene promoters (PubMed:25180232).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
66255, 121 interactors

Database of interacting proteins

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DIPi
DIP-60434N

Protein interaction database and analysis system

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IntActi
Q94527, 137 interactors

Molecular INTeraction database

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MINTi
Q94527

STRING: functional protein association networks

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STRINGi
7227.FBpp0088375

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q94527

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini147 – 339RHDPROSITE-ProRule annotationAdd BLAST193
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati640 – 669ANK 1CuratedAdd BLAST30
Repeati673 – 702ANK 2CuratedAdd BLAST30
Repeati710 – 740ANK 3CuratedAdd BLAST31
Repeati745 – 775ANK 4CuratedAdd BLAST31
Repeati783 – 812ANK 5CuratedAdd BLAST30

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi452 – 457Nuclear localization signalSequence analysis6

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164992

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q94527

KEGG Orthology (KO)

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KOi
K02580

Identification of Orthologs from Complete Genome Data

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OMAi
CAIHLAV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q94527

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01177 IPT_NFkappaB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.20, 1 hit
2.60.40.10, 1 hit
2.60.40.340, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR033926 IPT_NFkappaB
IPR000451 NFkB/Dor
IPR008967 p53-like_TF_DNA-bd
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR24169 PTHR24169, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00057 NFKBTNSCPFCT

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00248 ANK, 6 hits
SM00429 IPT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48403 SSF48403, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50254 REL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Major1 Publication (identifier: Q94527-1) [UniParc]FASTAAdd to basket
Also known as: A1 Publication, B, C, p1101 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNMNQYYDLD NGKNVMFMND ASSTSGYSSS TSPNSTNRSF SPAHSPKTME
60 70 80 90 100
LQTDFANLNL PGGNSPHQPP MANSPYQNQL LNNGGICQLG ATNLINSTGV
110 120 130 140 150
SFGVANVTSF GNMYMDHQYF VPAPATVPPS QNFGYHQNGL ASDGDIKHVP
160 170 180 190 200
QLRIVEQPVE KFRFRYKSEM HGTHGSLNGA NSKRTPKTFP EVTLCNYDGP
210 220 230 240 250
AVIRCSLFQT NLDSPHSHQL VVRKDDRDVC DPHDLHVSKE RGYVAQFINM
260 270 280 290 300
GIIHTAKKYI FEELCKKKQD RLVFQMNRRE LSHKQLQELH QETEREAKDM
310 320 330 340 350
NLNQVRLCFE AFKIEDNGAW VPLAPPVYSN AINNRKSAQT GELRIVRLSK
360 370 380 390 400
PTGGVMGNDE LILLVEKVSK KNIKVRFFEE DEDGETVWEA YAKFRESDVH
410 420 430 440 450
HQYAIVCQTP PYKDKDVDRE VNVYIELIRP SDDERSFPAL PFRYKPRSVI
460 470 480 490 500
VSRKRRRTGS SANSSSSGTE SSNNSLDLPK TLGLAQPPNG LPNLSQHDQT
510 520 530 540 550
ISEEFGREKH LNEFIASEDF RKLIEHNSSD LEKICQLDMG ELQHDGHNRA
560 570 580 590 600
EVPSHRNRTI KCLDDLFEIY KQDRISPIKI SHHKVEKWFI EHALNNYNRD
610 620 630 640 650
TLLHEVISHK KDKLKLAIQT IQVMNYFNLK DVVNSTLNAD GDSALHVACQ
660 670 680 690 700
QDRAHYIRPL LGMGCNPNLK NNAGNTPLHV AVKEEHLSCV ESFLNGVPTV
710 720 730 740 750
QLDLSLTNDD GLTPLHMAIR QNKYDVAKKL ISYDRTSISV ANTMDGNNAL
760 770 780 790 800
HMAVLEQSVE LLVLILDAQN ENLTDILQAQ NAAGHTPLEL AERKANDRVV
810 820 830 840 850
QLLKNVYPEK GELAMTWIPC KVKEEIDSSS DESSDAGQLE IKSEEMDIET
860 870 880 890 900
KDEDSVELDL SSGPRRQKDE SSRDTEMDNN KLQLLLKNKF IYDRLCSLLN
910 920 930 940 950
QPLGHGSDPQ DRKWMQLARQ THLKQFAFIW LGAEDLLDHV KRKGASVEFS
960 970
TFARALQAVD PQAYALLVNP T
Length:971
Mass (Da):109,775
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAF607357381AD32
GO
Isoform Maternal1 Publication (identifier: Q94527-2) [UniParc]FASTAAdd to basket
Also known as: D1 Publication, p1001 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Show »
Length:859
Mass (Da):97,894
Checksum:i1F9784818C642F99
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti114Missing in AAF07086 (PubMed:10619029).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti82N → S in strain: Zim2. 1 Publication1
Natural varianti110F → L in strain: Zim3. 1 Publication1
Natural varianti699T → I in strain: Zim8. 1 Publication1
Natural varianti845E → G in strain: Zim1. 1 Publication1
Natural varianti862S → N in strain: Zim8. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0500891 – 112Missing in isoform Maternal. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U62005 mRNA Translation: AAB17264.1
AF186073 Genomic DNA Translation: AAF07931.1
AF186073 Genomic DNA Translation: AAF07932.1
AF186077 Genomic DNA Translation: AAF07086.1
AF186078 Genomic DNA Translation: AAF07087.2
AE014297 Genomic DNA Translation: AAF54333.2
AE014297 Genomic DNA Translation: AAS65130.1
AE014297 Genomic DNA Translation: AAS65131.1
AE014297 Genomic DNA Translation: AAS65132.1
AY058264 mRNA Translation: AAL13493.1
AF204284 Genomic DNA Translation: AAF20132.1
AF204285 Genomic DNA Translation: AAF20133.1
AF204286 Genomic DNA Translation: AAF20134.1
AF204287 Genomic DNA Translation: AAF20135.1
AF204288 Genomic DNA Translation: AAF20136.1
AF204289 Genomic DNA Translation: AAF20137.1

NCBI Reference Sequences

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RefSeqi
NP_477094.1, NM_057746.4 [Q94527-1]
NP_996187.1, NM_206465.1 [Q94527-2]
NP_996188.1, NM_206466.1 [Q94527-1]
NP_996189.1, NM_206467.1 [Q94527-1]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0089338; FBpp0088375; FBgn0014018 [Q94527-1]
FBtr0089339; FBpp0088973; FBgn0014018 [Q94527-1]
FBtr0089340; FBpp0088971; FBgn0014018 [Q94527-1]
FBtr0089341; FBpp0088972; FBgn0014018 [Q94527-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
41087

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG11992

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62005 mRNA Translation: AAB17264.1
AF186073 Genomic DNA Translation: AAF07931.1
AF186073 Genomic DNA Translation: AAF07932.1
AF186077 Genomic DNA Translation: AAF07086.1
AF186078 Genomic DNA Translation: AAF07087.2
AE014297 Genomic DNA Translation: AAF54333.2
AE014297 Genomic DNA Translation: AAS65130.1
AE014297 Genomic DNA Translation: AAS65131.1
AE014297 Genomic DNA Translation: AAS65132.1
AY058264 mRNA Translation: AAL13493.1
AF204284 Genomic DNA Translation: AAF20132.1
AF204285 Genomic DNA Translation: AAF20133.1
AF204286 Genomic DNA Translation: AAF20134.1
AF204287 Genomic DNA Translation: AAF20135.1
AF204288 Genomic DNA Translation: AAF20136.1
AF204289 Genomic DNA Translation: AAF20137.1
RefSeqiNP_477094.1, NM_057746.4 [Q94527-1]
NP_996187.1, NM_206465.1 [Q94527-2]
NP_996188.1, NM_206466.1 [Q94527-1]
NP_996189.1, NM_206467.1 [Q94527-1]

3D structure databases

SMRiQ94527
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi66255, 121 interactors
DIPiDIP-60434N
IntActiQ94527, 137 interactors
MINTiQ94527
STRINGi7227.FBpp0088375

PTM databases

iPTMnetiQ94527

Proteomic databases

PaxDbiQ94527
PRIDEiQ94527

Genome annotation databases

EnsemblMetazoaiFBtr0089338; FBpp0088375; FBgn0014018 [Q94527-1]
FBtr0089339; FBpp0088973; FBgn0014018 [Q94527-1]
FBtr0089340; FBpp0088971; FBgn0014018 [Q94527-1]
FBtr0089341; FBpp0088972; FBgn0014018 [Q94527-2]
GeneIDi41087
KEGGidme:Dmel_CG11992

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5966
FlyBaseiFBgn0014018 Rel

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000164992
InParanoidiQ94527
KOiK02580
OMAiCAIHLAV
PhylomeDBiQ94527

Enzyme and pathway databases

ReactomeiR-DME-1169091 Activation of NF-kappaB in B cells
R-DME-1810476 RIP-mediated NFkB activation via ZBP1
R-DME-202424 Downstream TCR signaling
R-DME-209394 Transcriptional activtion and repression of REL-68 target genes
R-DME-209560 NF-kB is activated and signals survival
R-DME-214399 Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214411 REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214416 Phosphorylated REL is cleaved by and dissociates from DREDD
R-DME-2871837 FCERI mediated NF-kB activation
R-DME-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-DME-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-DME-4755510 SUMOylation of immune response proteins
R-DME-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-5621575 CD209 (DC-SIGN) signaling
R-DME-5676590 NIK-->noncanonical NF-kB signaling
R-DME-6798695 Neutrophil degranulation
R-DME-9020702 Interleukin-1 signaling
R-DME-933542 TRAF6 mediated NF-kB activation
SignaLinkiQ94527

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
41087 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
41087

Protein Ontology

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PROi
PR:Q94527

Gene expression databases

BgeeiFBgn0014018 Expressed in embryonic/larval hemocyte (Drosophila) and 51 other tissues
ExpressionAtlasiQ94527 baseline and differential
GenevisibleiQ94527 DM

Family and domain databases

CDDicd01177 IPT_NFkappaB, 1 hit
Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR033926 IPT_NFkappaB
IPR000451 NFkB/Dor
IPR008967 p53-like_TF_DNA-bd
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR24169 PTHR24169, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR00057 NFKBTNSCPFCT
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00429 IPT, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50254 REL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFKB1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94527
Secondary accession number(s): A4V2K3
, Q9U435, Q9U436, Q9U437, Q9U438, Q9U439, Q9U440, Q9U6H3, Q9U6H4, Q9U6H5, Q9VHI0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: February 1, 1997
Last modified: June 17, 2020
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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