UniProtKB - Q94524 (DYLT_DROME)
Dynein light chain Tctex-type
Dlc90F
Functioni
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Required for spermatid differentiation. Is not required for polarized transport in rhabdomere development and appears to be a non-essential component of the cytoplasmic dynein complex.
1 PublicationGO - Molecular functioni
- disordered domain specific binding Source: CAFA
- dynein intermediate chain binding Source: FlyBase
- dynein light intermediate chain binding Source: FlyBase
- identical protein binding Source: IntAct
- protein homodimerization activity Source: FlyBase
GO - Biological processi
- determination of adult lifespan Source: FlyBase
- microtubule-based movement Source: GO_Central
- mitotic cell cycle Source: FlyBase
- retrograde axonal transport Source: FlyBase
- spermatid development Source: FlyBase
Keywordsi
Molecular function | Motor protein |
Enzyme and pathway databases
Reactomei | R-DME-6798695, Neutrophil degranulation |
SignaLinki | Q94524 |
Names & Taxonomyi
Protein namesi | Recommended name: Dynein light chain Tctex-typeAlternative name(s): TCTEX-1 protein homolog |
Gene namesi | Name:Dlc90F Synonyms:Tctex ORF Names:CG12363 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0024432, Dlc90F |
VEuPathDBi | VectorBase:FBgn0024432 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Curated
Cytoskeleton
- cytoplasmic dynein complex Source: FlyBase
- dynein complex Source: FlyBase
- microtubule Source: UniProtKB-KW
Other locations
- axon cytoplasm Source: GOC
- cytoplasm Source: GO_Central
- protein-containing complex Source: CAFA
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Dynein, MicrotubulePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000195155 | 1 – 111 | Dynein light chain Tctex-typeAdd BLAST | 111 |
Proteomic databases
PaxDbi | Q94524 |
PRIDEi | Q94524 |
Expressioni
Gene expression databases
Bgeei | FBgn0024432, Expressed in embryo and 48 other tissues |
ExpressionAtlasi | Q94524, baseline and differential |
Genevisiblei | Q94524, DM |
Interactioni
Subunit structurei
The cytoplasmic dynein complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).
By similarityBinary interactionsi
Q94524
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-158251,EBI-158251 |
Dmel\CG5359 [Q9VH45] | 4 | EBI-158251,EBI-155608 |
Hsp67Bc [P22979] | 6 | EBI-158251,EBI-165408 |
msb1l [Q9VIT3] | 3 | EBI-158251,EBI-121559 |
GO - Molecular functioni
- disordered domain specific binding Source: CAFA
- dynein intermediate chain binding Source: FlyBase
- dynein light intermediate chain binding Source: FlyBase
- identical protein binding Source: IntAct
- protein homodimerization activity Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 67217, 48 interactors |
DIPi | DIP-17339N |
IntActi | Q94524, 24 interactors |
MINTi | Q94524 |
STRINGi | 7227.FBpp0082996 |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q94524 |
SMRi | Q94524 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q94524 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4081, Eukaryota |
GeneTreei | ENSGT00940000154531 |
HOGENOMi | CLU_097204_7_2_1 |
InParanoidi | Q94524 |
OMAi | TSDACYV |
OrthoDBi | 1474572at2759 |
PhylomeDBi | Q94524 |
Family and domain databases
Gene3Di | 3.30.1140.40, 1 hit |
IDEALi | IID50099 |
InterProi | View protein in InterPro IPR005334, Tctex-1-like IPR038586, Tctex-1-like_sf |
PANTHERi | PTHR21255, PTHR21255, 1 hit |
Pfami | View protein in Pfam PF03645, Tctex-1, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MDDSREESQF IVDDVSKTIK EAIETTIGGN AYQHDKVNNW TGQVVENCLT
60 70 80 90 100
VLTKEQKPYK YIVTAMIMQK NGAGLHTASS CYWNNDTDGS CTVRWENKTM
110
YCIVSVFGLA V
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y08968 mRNA Translation: CAA70165.1 AF123058 Genomic DNA Translation: AAD30033.1 AE014297 Genomic DNA Translation: AAF55532.1 AY069608 mRNA Translation: AAL39753.1 |
RefSeqi | NP_477356.1, NM_058008.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0083575; FBpp0082996; FBgn0024432 |
GeneIDi | 42199 |
KEGGi | dme:Dmel_CG12363 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y08968 mRNA Translation: CAA70165.1 AF123058 Genomic DNA Translation: AAD30033.1 AE014297 Genomic DNA Translation: AAF55532.1 AY069608 mRNA Translation: AAL39753.1 |
RefSeqi | NP_477356.1, NM_058008.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1YGT | X-ray | 1.70 | A | 1-111 | [»] | |
2PG1 | X-ray | 2.80 | E/F/G/H | 1-111 | [»] | |
3FM7 | X-ray | 3.50 | A/B | 1-111 | [»] | |
AlphaFoldDBi | Q94524 | |||||
SMRi | Q94524 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 67217, 48 interactors |
DIPi | DIP-17339N |
IntActi | Q94524, 24 interactors |
MINTi | Q94524 |
STRINGi | 7227.FBpp0082996 |
Proteomic databases
PaxDbi | Q94524 |
PRIDEi | Q94524 |
Protocols and materials databases
DNASUi | 42199 |
Genome annotation databases
EnsemblMetazoai | FBtr0083575; FBpp0082996; FBgn0024432 |
GeneIDi | 42199 |
KEGGi | dme:Dmel_CG12363 |
Organism-specific databases
CTDi | 42199 |
FlyBasei | FBgn0024432, Dlc90F |
VEuPathDBi | VectorBase:FBgn0024432 |
Phylogenomic databases
eggNOGi | KOG4081, Eukaryota |
GeneTreei | ENSGT00940000154531 |
HOGENOMi | CLU_097204_7_2_1 |
InParanoidi | Q94524 |
OMAi | TSDACYV |
OrthoDBi | 1474572at2759 |
PhylomeDBi | Q94524 |
Enzyme and pathway databases
Reactomei | R-DME-6798695, Neutrophil degranulation |
SignaLinki | Q94524 |
Miscellaneous databases
BioGRID-ORCSi | 42199, 1 hit in 3 CRISPR screens |
EvolutionaryTracei | Q94524 |
GenomeRNAii | 42199 |
PROi | PR:Q94524 |
Gene expression databases
Bgeei | FBgn0024432, Expressed in embryo and 48 other tissues |
ExpressionAtlasi | Q94524, baseline and differential |
Genevisiblei | Q94524, DM |
Family and domain databases
Gene3Di | 3.30.1140.40, 1 hit |
IDEALi | IID50099 |
InterProi | View protein in InterPro IPR005334, Tctex-1-like IPR038586, Tctex-1-like_sf |
PANTHERi | PTHR21255, PTHR21255, 1 hit |
Pfami | View protein in Pfam PF03645, Tctex-1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DYLT_DROME | |
Accessioni | Q94524Primary (citable) accession number: Q94524 Secondary accession number(s): Q9VE95 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | February 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families