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Entry version 133 (12 Aug 2020)
Sequence version 3 (11 Jul 2006)
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Protein

Sulfate permease family protein 3

Gene

sulp-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possible sulfate transporter.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-174362, Transport and synthesis of PAPS
R-CEL-427601, Multifunctional anion exchangers

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.53.2.20, the sulfate permease (sulp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sulfate permease family protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sulp-3
ORF Names:F41D9.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
F41D9.5 ; CE38957 ; WBGene00018283 ; sulp-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 52HelicalSequence analysisAdd BLAST23
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000801931 – 782Sulfate permease family protein 3Add BLAST782

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q94225

PRoteomics IDEntifications database

More...
PRIDEi
Q94225

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00018283, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
46016, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.F41D9.5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q94225

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini546 – 700STASPROSITE-ProRule annotationAdd BLAST155

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0236, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183057

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003182_9_4_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q94225

KEGG Orthology (KO)

More...
KOi
K14453

Identification of Orthologs from Complete Genome Data

More...
OMAi
WERCKSE

Database of Orthologous Groups

More...
OrthoDBi
690428at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q94225

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018045, S04_transporter_CS
IPR011547, SLC26A/SulP_dom
IPR001902, SLC26A/SulP_fam
IPR002645, STAS_dom
IPR036513, STAS_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11814, PTHR11814, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01740, STAS, 1 hit
PF00916, Sulfate_transp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52091, SSF52091, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00815, sulP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01130, SLC26A, 1 hit
PS50801, STAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: Q94225-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYKKMSLRQL FSDRPPLNAV LQEKAQKLRY ACSPSKCIHS LLSFLPIITW
60 70 80 90 100
LPKYDWSHSF FGDLSGGLTM AVFSVPQGIA LASITGVPPV YGLYTAIFPS
110 120 130 140 150
FLYIFFGTSK HNALGGFAVL SLMTHGAIEK VMLRTATSYN ATAYVNHTLD
160 170 180 190 200
ELLDKENETA LISNTTLMQI LGNETSFVEE VTMEMWTEGV TPVKQIHVAT
210 220 230 240 250
TIIFLAGVIQ VFMGVFRLQY LTSLFSEQVM SGFVVGGGIH VFFAQIGNML
260 270 280 290 300
GIELPRRSGP GYLYYRIWDL VENLDNVHIP TVCISLSSFL FLVFGKEYLA
310 320 330 340 350
PWLNSAFNYP VPFELVLVVV GITATNYAEL SLRHDVKVVG NIPTEFPPPS
360 370 380 390 400
LPRFDLIRHI GLNAAAIAIT AVAIHITVAK VVEKRYKYKI NHGQELYALG
410 420 430 440 450
FVGVLSSFFP VFPVTSGFAR SVVGAAVGGS TQLTCLFSSL ALLSVILCIG
460 470 480 490 500
PALEYLPQCI LSAMIIFAQK GMLEKFGELK SLWPVFKIDF TIWLMSFFLT
510 520 530 540 550
VCYDMGEGLL MAIGFAVLTT IIRTQRPKWH FLSRDDDTEN YKETKKRDLE
560 570 580 590 600
RIQGNVCIFR MDAPLIFTSS DRFTMSVWQC VKKWERCKSE SFVTIEQMNS
610 620 630 640 650
DRSADIFDSK LKSARRRWKR DQKSENRCKL VIDCDGFPYV DYLGLSTLKS
660 670 680 690 700
VYVDLQAAGI QCFFVVQKSD LKKLFRATDF YEVVDESKVF NKVGDAVKAA
710 720 730 740 750
EQHISSPKTT KEILTALASI ATTDTVLIDE ESSDSNDNDD AEIQERITEE
760 770 780
SENSEEVMSE TSVSIEDATS LTSSRNSINS EE
Length:782
Mass (Da):87,475
Last modified:July 11, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36F1A26BAFF3DA3C
GO
Isoform b (identifier: Q94225-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     318-345: VVVGITATNYAELSLRHDVKVVGNIPTE → LTHYLINR

Show »
Length:762
Mass (Da):85,509
Checksum:iCA563FE521A66EA4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019780318 – 345VVVGI…NIPTE → LTHYLINR in isoform b. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY887909 mRNA Translation: AAX34421.1
AY954524 mRNA Translation: AAX34432.2
FO081091 Genomic DNA Translation: CCD69047.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T25751

NCBI Reference Sequences

More...
RefSeqi
NP_509424.2, NM_077023.4 [Q94225-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F41D9.5.1; F41D9.5.1; WBGene00018283 [Q94225-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
181094

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F41D9.5

UCSC genome browser

More...
UCSCi
F41D9.5, c. elegans [Q94225-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY887909 mRNA Translation: AAX34421.1
AY954524 mRNA Translation: AAX34432.2
FO081091 Genomic DNA Translation: CCD69047.1
PIRiT25751
RefSeqiNP_509424.2, NM_077023.4 [Q94225-1]

3D structure databases

SMRiQ94225
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi46016, 1 interactor
STRINGi6239.F41D9.5

Protein family/group databases

TCDBi2.A.53.2.20, the sulfate permease (sulp) family

Proteomic databases

PaxDbiQ94225
PRIDEiQ94225

Genome annotation databases

EnsemblMetazoaiF41D9.5.1; F41D9.5.1; WBGene00018283 [Q94225-1]
GeneIDi181094
KEGGicel:CELE_F41D9.5
UCSCiF41D9.5, c. elegans [Q94225-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181094
WormBaseiF41D9.5 ; CE38957 ; WBGene00018283 ; sulp-3

Phylogenomic databases

eggNOGiKOG0236, Eukaryota
GeneTreeiENSGT00950000183057
HOGENOMiCLU_003182_9_4_1
InParanoidiQ94225
KOiK14453
OMAiWERCKSE
OrthoDBi690428at2759
PhylomeDBiQ94225

Enzyme and pathway databases

ReactomeiR-CEL-174362, Transport and synthesis of PAPS
R-CEL-427601, Multifunctional anion exchangers

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q94225

Gene expression databases

BgeeiWBGene00018283, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR018045, S04_transporter_CS
IPR011547, SLC26A/SulP_dom
IPR001902, SLC26A/SulP_fam
IPR002645, STAS_dom
IPR036513, STAS_dom_sf
PANTHERiPTHR11814, PTHR11814, 1 hit
PfamiView protein in Pfam
PF01740, STAS, 1 hit
PF00916, Sulfate_transp, 1 hit
SUPFAMiSSF52091, SSF52091, 1 hit
TIGRFAMsiTIGR00815, sulP, 1 hit
PROSITEiView protein in PROSITE
PS01130, SLC26A, 1 hit
PS50801, STAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSULP3_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94225
Secondary accession number(s): Q58G77, Q58QG5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 11, 2006
Last modified: August 12, 2020
This is version 133 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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