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Entry version 159 (29 Sep 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Delta-1-pyrroline-5-carboxylate synthase 2

Gene

P5CS2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants. Involved in abiotic stress tolerance.

1 Publication

Miscellaneous

Tobacco plants over-expressing P5CS1 and P5CS2 have elevated proline levels and display enhanced abiotic stress tolerance.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Feedback regulated by proline.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-proline biosynthesis

This protein is involved in step 1 and 2 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate. This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei79SubstrateBy similarity1
Binding sitei176SubstrateBy similarity1
Binding sitei195Substrate; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi215 – 216ATPBy similarity2
Nucleotide bindingi221 – 226ATPBy similarity6
Nucleotide bindingi255 – 261ATPBy similarity7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Multifunctional enzyme, Oxidoreductase, Transferase
Biological processAmino-acid biosynthesis, Proline biosynthesis, Stress response
LigandATP-binding, NADP, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.2.1.41, 4460

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00098;UER00359
UPA00098;UER00360

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Delta-1-pyrroline-5-carboxylate synthase 2Curated
Short name:
OsP5CS21 Publication
Including the following 2 domains:
Glutamate 5-kinase (EC:2.7.2.11)
Short name:
GK
Alternative name(s):
Gamma-glutamyl kinase
Gamma-glutamyl phosphate reductase (EC:1.2.1.41)
Short name:
GPR
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:P5CS21 Publication
Ordered Locus Names:Os01g0848200Imported
ORF Names:OsJ_04075Imported, P0005H10.23Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryza sativa subsp. japonica (Rice)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39947 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007752 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1
  • UP000059680 Componenti: Chromosome 1
  • UP000000763 Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004398251 – 735Delta-1-pyrroline-5-carboxylate synthase 2Add BLAST735

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q941T1

PRoteomics IDEntifications database

More...
PRIDEi
Q941T1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4530.OS01T0848200-02

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q941T1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 315Glutamate 5-kinaseAdd BLAST315
Regioni316 – 735Gamma-glutamyl phosphate reductaseAdd BLAST420

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the glutamate 5-kinase family.Curated
In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1154, Eukaryota
KOG4165, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016144_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q941T1

Identification of Orthologs from Complete Genome Data

More...
OMAi
YSDLECC

Database of Orthologous Groups

More...
OrthoDBi
832430at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07079, ALDH_F18-19_ProA-GPR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1160.10, 1 hit
3.40.309.10, 1 hit
3.40.605.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00412, ProA, 1 hit
MF_00456, ProB, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036393, AceGlu_kinase-like_sf
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR001048, Asp/Glu/Uridylate_kinase
IPR020593, G-glutamylP_reductase_CS
IPR001057, Glu/AcGlu_kinase
IPR005715, Glu_5kinase/COase_Synthase
IPR019797, Glutamate_5-kinase_CS
IPR000965, GPR_dom
IPR005766, P5_carboxy_syn

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00696, AA_kinase, 1 hit
PF00171, Aldedh, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036429, P5C_syn, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00474, GLU5KINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53633, SSF53633, 1 hit
SSF53720, SSF53720, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01092, P5CS, 1 hit
TIGR00407, proA, 1 hit
TIGR01027, proB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00902, GLUTAMATE_5_KINASE, 1 hit
PS01223, PROA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q941T1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRGGIGGAG LVAAVAKADV ENTDSTRGFV KDVKRIIIKV GTAVVTGPNG
60 70 80 90 100
RLAMGRLGAL CEQVKQLNFE GYEVILVTSG AVGVGRQRLK YRKLVNSSFA
110 120 130 140 150
DLQNPQMDMD GKACAAVGQS VLMAIYDTLF SQLDVTSSQL LVTDRDFMDP
160 170 180 190 200
SFGNQLRETV NSLLDLKVIP VFNENDAIST RRQPYEDSSG IFWDNDSLAR
210 220 230 240 250
LLAQELKADL LIMLSDVEGL YSGPPSDPQS KIIHTYVHEQ HGKLISFGEK
260 270 280 290 300
SRVGRGGMQA KVAAAFTASS KGIPVVIASG FAIDSIIKVM RGEKIGTLFH
310 320 330 340 350
REANQWGCSK EATAREMAVA ARDCSRHLQK LSSEERKKIL LDIADALEAN
360 370 380 390 400
EDLITSENQA DLDLAQDIGY DKSLVARMTI KPGKIKSLAG SIREIADMED
410 420 430 440 450
PISHTLKRTE VAKDLVFEKT YCPLGVLLII FESRPDALVQ IASLAIRSGN
460 470 480 490 500
GLLLKGGKEA MRSNTILHKV ITGAIPDVVG KKLIGLVKNK DEIADLLKLD
510 520 530 540 550
DVIDLVIPRG SNKLVSQIKA ATKIPVLGHA DGICHVYIDK SADMDMAKRI
560 570 580 590 600
VLDAKVDYPA ACNAMETLLV HKDLNRTEGL DDLLVELEKE GVVIYGGPVA
610 620 630 640 650
HDTLKLPKVD SFHHEYNSMA CTLEFVDDVQ SAIDHINRYG SAHTDCIITT
660 670 680 690 700
DGKAAETFLQ QVDSAAVFHN ASTRFCDGAR FGLGAEVGIS TGRIHARGPV
710 720 730
GVDGLLTTRC ILRGSGQVVN GDKGVVYTHR ELPLQ
Length:735
Mass (Da):79,508
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC14C53D50B63B572
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP004127 Genomic DNA Translation: BAB64280.1
AP008207 Genomic DNA Translation: BAF06716.1
AP014957 Genomic DNA Translation: BAS75219.1
CM000138 Genomic DNA Translation: EEE55670.1
AK101230 mRNA Translation: BAG94966.1

NCBI Reference Sequences

More...
RefSeqi
XP_015622203.1, XM_015766717.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
Os01t0848200-01; Os01t0848200-01; Os01g0848200
Os01t0848200-02; Os01t0848200-02; Os01g0848200

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4324853

Gramene; a comparative resource for plants

More...
Gramenei
Os01t0848200-01; Os01t0848200-01; Os01g0848200
Os01t0848200-02; Os01t0848200-02; Os01g0848200

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
osa:4324853

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004127 Genomic DNA Translation: BAB64280.1
AP008207 Genomic DNA Translation: BAF06716.1
AP014957 Genomic DNA Translation: BAS75219.1
CM000138 Genomic DNA Translation: EEE55670.1
AK101230 mRNA Translation: BAG94966.1
RefSeqiXP_015622203.1, XM_015766717.1

3D structure databases

SMRiQ941T1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4530.OS01T0848200-02

Proteomic databases

PaxDbiQ941T1
PRIDEiQ941T1

Genome annotation databases

EnsemblPlantsiOs01t0848200-01; Os01t0848200-01; Os01g0848200
Os01t0848200-02; Os01t0848200-02; Os01g0848200
GeneIDi4324853
GrameneiOs01t0848200-01; Os01t0848200-01; Os01g0848200
Os01t0848200-02; Os01t0848200-02; Os01g0848200
KEGGiosa:4324853

Phylogenomic databases

eggNOGiKOG1154, Eukaryota
KOG4165, Eukaryota
HOGENOMiCLU_016144_0_0_1
InParanoidiQ941T1
OMAiYSDLECC
OrthoDBi832430at2759

Enzyme and pathway databases

UniPathwayiUPA00098;UER00359
UPA00098;UER00360
BRENDAi1.2.1.41, 4460

Family and domain databases

CDDicd07079, ALDH_F18-19_ProA-GPR, 1 hit
Gene3Di3.40.1160.10, 1 hit
3.40.309.10, 1 hit
3.40.605.10, 1 hit
HAMAPiMF_00412, ProA, 1 hit
MF_00456, ProB, 1 hit
InterProiView protein in InterPro
IPR036393, AceGlu_kinase-like_sf
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR001048, Asp/Glu/Uridylate_kinase
IPR020593, G-glutamylP_reductase_CS
IPR001057, Glu/AcGlu_kinase
IPR005715, Glu_5kinase/COase_Synthase
IPR019797, Glutamate_5-kinase_CS
IPR000965, GPR_dom
IPR005766, P5_carboxy_syn
PfamiView protein in Pfam
PF00696, AA_kinase, 1 hit
PF00171, Aldedh, 1 hit
PIRSFiPIRSF036429, P5C_syn, 1 hit
PRINTSiPR00474, GLU5KINASE
SUPFAMiSSF53633, SSF53633, 1 hit
SSF53720, SSF53720, 1 hit
TIGRFAMsiTIGR01092, P5CS, 1 hit
TIGR00407, proA, 1 hit
TIGR01027, proB, 1 hit
PROSITEiView protein in PROSITE
PS00902, GLUTAMATE_5_KINASE, 1 hit
PS01223, PROA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP5CS2_ORYSJ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q941T1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: December 1, 2001
Last modified: September 29, 2021
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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